Zobrazeno 1 - 10
of 106
pro vyhledávání: '"B. Tulloch"'
Autor:
Jacqueline Howie, Lindsay B. Tulloch, Elaine Brown, Louise Reilly, Fiona B. Ashford, Jennifer Kennedy, Krzysztof J. Wypijewski, Karen L. Aughton, Jason K.C. Mak, Michael J. Shattock, Niall J. Fraser, William Fuller
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113679- (2024)
Summary: Phospholemman (PLM) regulates the cardiac sodium pump: PLM phosphorylation activates the pump whereas PLM palmitoylation inhibits its activity. Here, we show that the anti-oxidant protein peroxiredoxin 6 (Prdx6) interacts with and depalmitoy
Externí odkaz:
https://doaj.org/article/dcac5956dc204ac4934750eee8fdf86f
Autor:
Lindsay B. Tulloch, Sandra Carvalho, Marta Lima, Richard J. Wall, Michele Tinti, Erika G. Pinto, Lorna MacLean, Susan Wyllie
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTVisceral leishmaniasis (VL) is a parasitic disease endemic across multiple regions of the world and is fatal if untreated. New therapeutic options with diverse mechanisms of actions (MoAs) are required to consolidate progress toward control o
Externí odkaz:
https://doaj.org/article/7bb16e5a50ee43d6b0b2d50b417e7077
Autor:
Magali Van den Kerkhof, Philippe Leprohon, Dorien Mabille, Sarah Hendrickx, Lindsay B. Tulloch, Richard J. Wall, Susan Wyllie, Eric Chatelain, Charles E. Mowbray, Stéphanie Braillard, Marc Ouellette, Louis Maes, Guy Caljon
Publikováno v:
Microorganisms, Vol 9, Iss 7, p 1408 (2021)
Current treatment options for visceral leishmaniasis have several drawbacks, and clinicians are confronted with an increasing number of treatment failures. To overcome this, the Drugs for Neglected Diseases initiative (DNDi) has invested in the devel
Externí odkaz:
https://doaj.org/article/3fffc5e0d8f34c3a82d0f26fc93ce6de
Autor:
Lindsay B Tulloch, Stefanie K Menzies, Andrew L Fraser, Eoin R Gould, Elizabeth F King, Marija K Zacharova, Gordon J Florence, Terry K Smith
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005886 (2017)
Current drugs to treat African sleeping sickness are inadequate and new therapies are urgently required. As part of a medicinal chemistry programme based upon the simplification of acetogenin-type ether scaffolds, we previously reported the promising
Externí odkaz:
https://doaj.org/article/d7cf23932e2a4bed826d40db10641a11
Autor:
Stephen Patterson, Marta Lopes Lima, Lorna MacLean, Susan Wyllie, David Horn, Lindsay B. Tulloch, Sonia Moniz, Ian H. Gilbert, Richard J. Wall, Victoriano Corpas-López, Fabio Zuccotto, Rachel Milne, Eva Rico, Carmine Marco Morgillo, Leah S. Torrie, Sandra Carvalho
Publikováno v:
Antimicrobial Agents and Chemotherapy
Phenotypic screening identified an arylsulfonamide compound with activity against Trypanosoma cruzi, the causative agent of Chagas’ disease. Comprehensive mode of action studies revealed that this compound primarily targets the T. cruzi proteasome,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f49c0c376d173d0316cb726b4e7b804
https://pubmed.ncbi.nlm.nih.gov/34606338
https://pubmed.ncbi.nlm.nih.gov/34606338
Autor:
Matthew D. Roberts, Stefanie K. Menzies, Gordon J. Florence, Ross P.. Coron, Lindsay B. Tulloch, Terry K. Smith
Publikováno v:
IUBMB Life. 70:9-22
Phenotypic assays are becoming increasingly more common among drug discovery practices, expanding drug target diversity as lead compounds identified through such screens are not limited to known targets. While increasing diversity is beneficial to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dbf7321516a2bfadd62534d5edffb5c
https://doi.org/10.1002/iub.1697
https://doi.org/10.1002/iub.1697
Autor:
Lindsay B. Tulloch, Stéphanie Braillard, Magali Van den Kerkhof, Dorien Mabille, Philippe Leprohon, Marc Ouellette, Louis Maes, Susan Wyllie, Eric Chatelain, Charles E. Mowbray, Guy Caljon, Sarah Hendrickx, Richard J. Wall
Publikováno v:
Microorganisms
Volume 9
Issue 7
Microorganisms, Vol 9, Iss 1408, p 1408 (2021)
Volume 9
Issue 7
Microorganisms, Vol 9, Iss 1408, p 1408 (2021)
Current treatment options for visceral leishmaniasis have several drawbacks, and clinicians are confronted with an increasing number of treatment failures. To overcome this, the Drugs for Neglected Diseases initiative (DNDi) has invested in the devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4e82c8e2dc4043d7ee2c74b4001f51
https://doi.org/10.3390/microorganisms9071408
https://doi.org/10.3390/microorganisms9071408
Publikováno v:
Parasitology. 145:175-183
SUMMARYNew drugs againstTrypanosoma brucei,the causative agent of Human African Trypanosomiasis, are urgently needed to replace the highly toxic and largely ineffective therapies currently used. The trypanosome alternative oxidase (TAO) is an essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19214dc1fee552aebe11b2db6d39abcf
https://doi.org/10.1017/s0031182016002109
https://doi.org/10.1017/s0031182016002109
Autor:
Terry K. Smith, Marija K. Zacharova, Gordon J. Florence, Stefanie K. Menzies, Lindsay B. Tulloch, Marie I. Thomson, Andrew L. Fraser, Elizabeth F. B. King, Joanne C. Morris, Eoin R. Gould
Publikováno v:
Chemmedchem
Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern. They are a burden to human and animal health, having the most devastating effect on the world′s poorest countries. Building upon our previously report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8e6f1d792dd488a2bb5f1e4565e36c
https://doi.org/10.1002/cmdc.201600210
https://doi.org/10.1002/cmdc.201600210
Autor:
Marija K. Zacharova, Gordon J. Florence, Andrew L. Fraser, Elizabeth F. B. King, Eoin R. Gould, Lindsay B. Tulloch, Stefanie K. Menzies, Terry K. Smith
This work was funded by the Leverhulme Trust (GJF) and the European Community’s Seventh Framework Programme under grant agreement No. 602773 [Project KINDRED] (TKS). Neglected tropical diseases caused by parasitic infections are an ongoing and incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6293b473edfeb86152a0498eab6a9686
https://hdl.handle.net/10023/16803
https://hdl.handle.net/10023/16803
