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CTS1: a p53-derived chimeric tumor suppressor gene with enhanced in vitro apoptotic properties

Autor: V Sierra, Emmanuel Conseiller, M Maratrat, C Venot, B Tocque, L Debussche, D Landais, L Bracco

Publikováno v: Journal of Clinical Investigation. 101:120-127

The clinical potential of the p53 tumor suppressor gene is being evaluated currently for gene therapy of cancer. We have built a variant of wild-type p53, chimeric tumor suppressor 1 (CTS1), in which we have replaced the domains that mediate its inac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6bab4c3a502dc75bc3186a417a9872
https://doi.org/10.1172/jci1140

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Solution structure of GAP SH3 domain by 1H NMR and spatial arrangement of essential Ras signaling-involved sequence

Autor: N. Fromage, B. Tocque, Fabrice Cornille, Christiane Garbay, Nathalie Jullian, Yinshan Yang, Bernard-Pierre Roques, M. Duchesne

Publikováno v: The EMBO Journal. 13:1270-1279

Src homology 3 (SH3) domains are found in numerous cytoplasmic proteins involved in intracellular signal transduction. We used 2-D 1H NMR to determine the structure of the SH3 domain of the guanosine triphosphatase-activating protein (GAP), an essent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44d29dd53a33c45983131c7a8b6c1d1
https://doi.org/10.1002/j.1460-2075.1994.tb06379.x

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Stimulation of mitogen-activated protein kinase by oncogenic Ras p21 in Xenopus oocytes. Requirement for Ras p21-GTPase-activating protein interaction

Autor: Martine Pomerance, Marlène Pierre, Fabien Schweighoffer, B Tocque

Publikováno v: Journal of Biological Chemistry. 267:16155-16160

p21ras plays an important role in the control of cell proliferation. The molecular mechanisms implicated are unknown. We report that the injection of oncogenic Lys12 Ras into Xenopus laevis oocytes promoted the activation of mitogen-activated protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fcf1b9bb450ae7102bbf87e9eb437e0
https://doi.org/10.1016/s0021-9258(18)41980-1

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Synthesis and biological evaluation of a new series of phenylhydroquinone derivatives as inhibitors of EGF-R-associated PTK activity

Autor: M E, Million, P, Mailliett, H, Chen, G, Bashiardes, J, Boiziau, F, Parker, A, Commerçon, B, Tocque, B P, Roques, C, Garbay

Publikováno v: Anti-cancer drug design. 11(2)

In order to design new potent inhibitors of the epidermal growth factor receptor (EGF-R) associated protein tyrosine kinase (PTK) activity as antitumor agents, several families of phenylhydroquinone derivatives were synthesized. Some of these compoun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ffda7835b4dd2314488880b5d96cdbba
https://pubmed.ncbi.nlm.nih.gov/8630186

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Synthesis and biological evaluation of a series of hydroxybenzylphenylamine derivatives as inhibitors of EGF receptor-associated tyrosine kinase activity

Autor: H, Chen, G, Bashiardes, P, Mailliet, A, Commercon, F, Sounigo, J, Boiziau, F, Parker, B, Tocque, B P, Roques, C, Garbay

Publikováno v: Anti-cancer drug design. 11(1)

In order to obtain non-degradable and more potent protein-tyrosine kinase inhibitors, derived from the 5-(2,5-dihydroxybenzyl)-aminosalicylates already described, we have developed a new series of 5-(2,5-dihydroxybenzyl)phenylamines. The compounds, d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c1d43e65d72d64400e4f431b5b2fc11
https://pubmed.ncbi.nlm.nih.gov/8639248

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MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest

Autor: M C, Dubs-Poterszman, B, Tocque, B, Wasylyk

Publikováno v: Oncogene. 11(11)

The p53 tumour-suppressor guards the genome in response to genotoxic stress by transcriptional regulation of genes involved in cell-cycle control, DNA replication, repair and apoptosis such as p21, GADD45, bax and mdm2 (Cox and Lane, 1995). Mdm2 is c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e887cdfa69de3f56e9a8bcf74c5e0d92
https://pubmed.ncbi.nlm.nih.gov/8570197

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Identification of a human guanine nucleotide-releasing factor (H-GRF55) specific for Ras proteins

Autor: F, Schweighoffer, M, Faure, I, Fath, M C, Chevallier-Multon, F, Apiou, B, Dutrillaux, E, Sturani, M, Jacquet, B, Tocque

Publikováno v: Oncogene. 8(6)

A critical step in the activation of cellular Ras is the release of bound GDP. Oligonucleotide primers derived from a mouse cDNA sequence homologous to the Saccharomyces cerevisiae CDC25 gene product were used to screen a human brain cDNA library. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ccc3d6b7ca2c4c68c541a2fe0a50a611
https://pubmed.ncbi.nlm.nih.gov/7684828

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The Saccharomyces cerevisiae gene product SDC25 C-domain functions as an oncoprotein in NIH3T3 cells

Autor: I, Barlat, F, Schweighoffer, M C, Chevallier-Multon, M, Duchesne, I, Fath, D, Landais, M, Jacquet, B, Tocque

Publikováno v: Oncogene. 8(1)

Ras proteins in mammalian cells cycle between a GTP-bound 'on' state and a GDP-bound 'off' state. Activation of Ras p21 results from the dissociation of tightly bound GDP and the exchange of bound GDP for GTP. A guanine nucleotide exchange factor is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b4299d86567870f5d79d06d19558879
https://pubmed.ncbi.nlm.nih.gov/7999142

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