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pro vyhledávání: '"B. T. Stadler"'
Publikováno v:
Journal of Biological Chemistry. 268:15929-15934
As is the case with many other peptide hormones of the brain and gut, gastrin requires a carboxyl-terminal amide moiety for optimal biological activity. In the structure of progastrin, the carboxyl-terminal Phe of gastrin is followed by the sequence
Publikováno v:
The American journal of physiology. 264(3 Pt 1)
Pancreatic polypeptide (PP) and gastrin are initially synthesized as larger precursors that require posttranslational processing to produce the biologically active peptides. These steps include tryptic cleavage at paired basic residues, their subsequ