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Akademický článek

Acute exacerbations in patients with progressive pulmonary fibrosis

Autor: Michael Kreuter, Elizabeth A. Belloli, Elisabeth Bendstrup, Stefania Cerri, Kevin R. Flaherty, Shane Shapera, Jin Woo Song, Heiko Mueller, Klaus B. Rohr, Yasuhiro Kondoh, on behalf of the INBUILD trial investigators, S. Quadrelli, M. Otaola, M.A. Bergna, P. Elias, G. Arce, A. Cazaux, J. Guiot, B. Bondue, C. Dahlqvist, L. Homik, S. Shapera, A. Cantin, M. Kolb, M. Salinas Fénero, R. Maturana Rozas, A. Silva Orellana, Z. Xu, Q. Luo, J. Kang, H. Cai, S. Marchand-Adam, E. Bergot, A. Gamez-Dubuis, F. Riviere, R. Kessler, H. Nunes, C. Marquette, L. Wemeau, S. Jouneau, F. Lebargy, B. Crestani, V. Cottin, M. Reynaud-Gaubert, S. Blaas, F. Bonella, W. Randerath, J. Hetzel, D. Koschel, M. Kreuter, A. Prasse, D. Skowasch, S. Stieglitz, R. Refini, S. Cerri, A. Pesci, S. Tomassetti, C. Vancheri, F. Varone, N. Sakamoto, S. Abe, H. Hayashi, T. Saito, T. Suda, H. Kitamura, M. Okamoto, Y. Kondoh, S. Makino, T. Takeuchi, Y. Yamada, C. Kono, Y. Inoue, H. Sugiura, K. Kishi, H. Takaya, H. Yamauchi, K. Ichikado, K. Tomii, H. Takahashi, S. Izumi, T. Kawamura, Y. Nishioka, Y. Miyazaki, J.W. Song, J.S. Park, Y. Kim, E. Jassem, J. Kus, W. Piotrowski, A. Barczyk, D. Ziora, E. Bazdyrev, S. Moiseev, S. Avdeev, M. Ilkovich, V. Yakusevich, C. Valenzuela, O. Acosta, M. Martínez, L. Gómez, M. Molina-Molina, D.M. Castillo Villegas, M. Aburto, J.A. Rodríguez Portal, A. Villar, A. León Jiménez, J. Sauleda, M. Arias, P. Beirne, H. Stone, B. Hope-Gill, N. Hirani, N. Chaudhuri, A. Gifford, L. Jones, L. Morrison, D. Antin-Ozerkis, N. Bhatt, T. Kulkarni, T. Moua, N. Ettinger, L. Pitts, S. Veeraraghavan, M. Padilla, E.R. Fernández Pérez, G. Giessel, M. Strek, S. Danoff, J. Burk, M. Rossman, N. Patel, E. Belloli, D. Hotchkin, S. Weigt, M.B. Scholand, R. Kaner, B. Sigal, Z. Safdar, L. Tolle, R. Martinez, M. Glassberg, R. Hallowell, J. Golden, M. Schwartz, E. Britt, L. Morrow, Y. Mageto, K. Buch, S. Chaaban, H. Poonyagariyagorn, D. Dilling, O. Shlobin, K. Thavarajah, A. Nambiar, I. Rosas, R. Bascom, J. Oldham, S. Schmidt, J. Dematte D'Amico, J. Falk, C. Glazer, G. Criner

Publikováno v: ERJ Open Research, Vol 10, Iss 6 (2024)

Background Acute exacerbations of fibrosing interstitial lung diseases (ILDs) are associated with high mortality. We used prospective data from the INBUILD trial to investigate risk factors for acute exacerbations and the impact of these events in pa

Externí odkaz: https://doaj.org/article/0ecb306ca6604466950a78b18ef4c07b

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Akademický článek

Exploratory factor analysis yields grouping of brain injury biomarkers significantly associated with outcomes in neonatal and pediatric ECMO

Autor: Victoria Huang, Jennifer Roem, Derek K. Ng, Jamie McElrath Schwartz, Allen D. Everett, Nikhil Padmanabhan, Daniel Romero, Jessica Joe, Christopher Campbell, George B. Sigal, Jacob N. Wohlstadter, Melania M. Bembea

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Abstract In this two-center prospective cohort study of children on ECMO, we assessed a panel of plasma brain injury biomarkers using exploratory factor analysis (EFA) to evaluate their interplay and association with outcomes. Biomarker concentration

Externí odkaz: https://doaj.org/article/8804e732b0b449efa92e101c2eb34350

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Akademický článek

Higher levels of brain injury biomarker tau are associated with unfavorable outcomes in patients supported with ECMO following cardiac arrest

Autor: Jamie McElrath Schwartz, Derek K. Ng, Jennifer Roem, Nikhil Padmanabhan, Daniel Romero, Jessica Joe, Christopher Campbell, George B. Sigal, Jacob N. Wohlstadter, Allen D. Everett, Melania M. Bembea

Publikováno v: Resuscitation Plus, Vol 18, Iss , Pp 100609- (2024)

Aim: We sought to determine if higher plasma levels of brain injury biomarkers neurofilament light (NfL), phosphorylated tau 181 (pT181), tau, and ubiquitin C-terminal hydrolase L1 (UCHL1) were associated with unfavorable outcomes in children support

Externí odkaz: https://doaj.org/article/834ff6633e5849379b68c26e6921c362

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Akademický článek

Elevation of neural injury markers in patients with neurologic sequelae after hospitalization for SARS-CoV-2 infection

Autor: Michail Spanos, Sigal Shachar, Thadryan Sweeney, H. Immo Lehmann, Priyanka Gokulnath, Guoping Li, George B. Sigal, Rajini Nagaraj, Pradeepthi Bathala, Farhan Rana, Ravi V. Shah, David A. Routenberg, Saumya Das

Publikováno v: iScience, Vol 25, Iss 8, Pp 104833- (2022)

Summary: Patients with SARS-CoV-2 infection (COVID-19) risk developing long-term neurologic symptoms after infection. Here, we identify biomarkers associated with neurologic sequelae one year after hospitalization for SARS-CoV-2 infection. SARS-CoV-2

Externí odkaz: https://doaj.org/article/038a4058d8e64404a52471da81c08966

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Akademický článek

Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region.

Autor: Leah G Jarsberg, Komal Kedia, Jason Wendler, Aaron T Wright, Paul D Piehowski, Marina A Gritsenko, Tujin Shi, David M Lewinsohn, George B Sigal, Marc H Weiner, Richard D Smith, Joseph Keane, Jon M Jacobs, Payam Nahid

Publikováno v: PLoS ONE, Vol 16, Iss 5, p e0250586 (2021)

IntroductionContemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes

Externí odkaz: https://doaj.org/article/b9145d89909b47d4854d0bccdbebc6ef

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