Výsledky vyhledávání - "B. Schiedlmeier"

Multidrug Resistance 1 Gene Transfer Can Confer Chemoprotection to Human Peripheral Blood Progenitor Cells Engrafted in Immunodeficient Mice

Autor: Klaus Kühlcke, Christopher Baum, Stephanie Laufs, Andrea Schilz, B. Schiedlmeier, Stefan Fruehauf, W. Jens Zeller, Eckert Hg

Publikováno v: Human Gene Therapy. 13:233-242

Myelosuppression is the main side effect of cancer chemotherapy. An improved rate of retroviral vector-mediated gene transfer to hematopoietic stem cells, shown in more recent clinical trials, has created the basis to test the concept of myeloprotect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2129a3706ba3e6a9318ab81e74b1ac37
https://doi.org/10.1089/10430340252769761

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Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice

Autor: B. Schiedlmeier, Klaus Kühlcke, S. Fruehauf, Christopher Baum, Eckert Hg, W. J. Zeller

Publikováno v: Blood. 95:1237-1248

Mobilized peripheral blood progenitor cells (PBPC) are a potential target for the retrovirus-mediated transfer of cytostatic drug-resistance genes. We analyzed nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse-repopulating CD34+ PBPC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e25bce3f414d1dce717edbe20596de6f
https://doi.org/10.1182/blood.v95.4.1237

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Relevance of Peripheral Blood Progenitor Cell Counts during Steady-State Hematopoiesis to Estimate the Number of Progenitor Cells Mobilized following Granulocyte Colony-Stimulating Factor-Supported Chemotherapy

Autor: W. J. Zeller, B. Schiedlmeier, M.R. Veldwijk, S. Martin, Rainer Haas, K. Schmitt, Stefan Fruehauf

Publikováno v: Transfusion Medicine and Hemotherapy. 26:103-109

Background: Peripheral blood progenitor cells can be mobilized using cytotoxic chemotherapy and cytokines. We were looking for predictive parameters indicating a patient’s response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40014c6220751e0a456beee6790c02e1
https://doi.org/10.1159/000053472

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The FBMD-1 stroma cell line secretes a unique moiety which can increase retroviral transduction of lineage-committed and primitive human peripheral blood progenitor cells

Autor: Eike C Buss, Stefan Fruehauf, Anthony D. Ho, B. Schiedlmeier, W. Jens Zeller

Publikováno v: Cancer gene therapy. 8(6)

Peripheral blood progenitor cells are a prime target for gene therapy approaches. As recent data point to the relevance of soluble stroma factors for the efficient transduction of progenitor cells, we tested the stroma-conditioned medium (SCM) of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb8d1893bfa1fa2419faf4f27213db9
https://pubmed.ncbi.nlm.nih.gov/11498764

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MDR1 gene expression in NOD/SCID repopulating cells after retroviral gene transfer under clinically relevant conditions

Autor: C. Lindemann, Stefan Fruehauf, Andrea Schilz, Christopher Baum, Manuel Grez, Klaus Kühlcke, W.J. Zeller, Eckert Hg, Axel A. Fauser, B. Schiedlmeier

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 2(6)

We have adapted a recently published protocol for retroviral gene transfer into hematopoietic cells [A. J. Schilz et al. (1998) Blood 92: 3163-3171] with respect to clinical requirements such as large-volume vector stock generation, adequate cell sou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e804f0a7fe73faf9f9c81ab3bebfed
https://pubmed.ncbi.nlm.nih.gov/11124062

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Differential expression of a recombinant adeno-associated virus 2 vector in human CD34+ cells and breast cancer cells

Autor: B. Schiedlmeier, Jürgen A. Kleinschmidt, W. J. Zeller, M.R. Veldwijk, Stefan Fruehauf

Publikováno v: Cancer gene therapy. 7(4)

The use of autologous hematopoietic stem cell (HSC) grafts after high-dose chemotherapy protocols may be hampered by contamination of the grafts with tumor cells. Because epithelial cells seem to be the natural hosts of adeno-associated virus 2 (AAV-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6af7605db112a76e6c8390483b95c8
https://pubmed.ncbi.nlm.nih.gov/10811478

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Retroviral vector-mediated expression of HoxB4 in hematopoietic cells using a novel coexpression strategy

Autor: Wolfram Ostertag, Martin D. Ryan, Birgit Vogt, Christopher Baum, B Schiedlmeier, Hannes Klump

Publikováno v: Gene therapy. 8(10)

Retroviral vector-mediated expression of the homeoboxgene, HoxB4, in hematopoietic cells has been reported to mediate a benign expansion of gene-modified hematopoietic stem and precursor cells in vivo. In the present study, we used a novel coexpressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70efe393abaa6180bb2d7458aead66ad
https://pubmed.ncbi.nlm.nih.gov/11420646

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Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks

Autor: B. Schiedlmeier, Jürgen A. Kleinschmidt, W. J. Zeller, M.R. Veldwijk, Stefan Fruehauf

Publikováno v: European journal of cancer (Oxford, England : 1990). 35(7)

Autologous peripheral blood progenitor cell (PBPC) grafts can be contaminated with tumour cells that potentially give rise to relapse following myeloablative therapy and PBPC transplantation. Adeno-associated virus (AAV)-based vectors produced by a n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676ca60b1edca81d06645e7fb33a9329
https://pubmed.ncbi.nlm.nih.gov/10533460

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Favorable therapeutic index of a p210(BCR-ABL)-specific tyrosine kinase inhibitor; activity on lineage-committed and primitive chronic myelogenous leukemia progenitors

Autor: A. D. Ho, B. Schiedlmeier, W. J. Zeller, Elisabeth Buchdunger, B. Kasper, Stefan Fruehauf

Publikováno v: Cancer chemotherapy and pharmacology. 44(5)

In order to assess the effect of the tyrosine kinase inhibitor CGP57148B on lineage-committed and primitive chronic myelogenous leukemia (CML) progenitor cells, peripheral blood progenitor cells (PBPC) mobilized in chronic phase CML were exposed to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b36f3147a2629dc5b15ad04b6dd988
https://pubmed.ncbi.nlm.nih.gov/10501919

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