Supplementary Methods, Figures 1 - 2, Tables 1 - 3 from CXM: A New Tool for Mapping Breast Cancer Risk in the Tumor Microenvironment

Autor: Howard J. Jacob, James D. Shull, Michael B. Dwinell, Peter S. LaViolette, Paula E. North, Jozef Lazar, Zelmira Lazarova, Scott C. Fahrenkrug, Wenfang Tan, Daniel F. Carlson, Jeffery De Pons, Shirng-Wern Tsaih, Sophia Ran, Carol Moreno, Aron M. Geurts, Angela Lemke, Ishan Roy, Stephanie Santarriaga, Allison B. Sarkis, Nathan Rudemiller, Bradley T. Endres, Michael J. Flister

Expanded Materials and Methods, Supplemental Figures, and Supplemental Tables Figure S1. Flow cytometric analysis of peripheral blood from SS, SS.BN3, SSIL2Rγ, and SS.BN3IL2Rγ rats. Figure S2.SH2B3 specifically marks CD31+ blood vessels, but not LY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c154ffd6a88cb5cd68a80a135811e4
https://doi.org/10.1158/0008-5472.22401336

CXM: A New Tool for Mapping Breast Cancer Risk in the Tumor Microenvironment

Autor: Howard J. Jacob, Peter S. LaViolette, James D. Shull, Jozef Lazar, Zelmira Lazarova, Sophia Ran, Carol Moreno, Ishan Roy, Jeffery De Pons, Aron M. Geurts, Wenfang Tan, Scott C. Fahrenkrug, Angela Lemke, Allison B. Sarkis, Michael J. Flister, Daniel F. Carlson, Michael B. Dwinell, Paula E. North, Stephanie Santarriaga, Shirng-Wern Tsaih, Nathan P. Rudemiller, Bradley T. Endres

Publikováno v: Cancer Research. 74:6419-6429

The majority of causative variants in familial breast cancer remain unknown. Of the known risk variants, most are tumor cell autonomous, and little attention has been paid yet to germline variants that may affect the tumor microenvironment. In this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129225670643b1ea8d3b66867c79bc47
https://doi.org/10.1158/0008-5472.can-13-3212

Genome Sequencing Reveals Loci under Artificial Selection that Underlie Disease Phenotypes in the Laboratory Rat

Autor: Pamela J. Kaisaki, Edwin Cuppen, Anna Dominiczak, Ana Garcia Diaz, Kathirvel Gopalakrishnan, Paul Flicek, Kathrin Saar, Timothy J. Aitman, Tadao Serikawa, David J. Adams, Georg W. Otto, Laurence Game, Dominique Gauguier, Michael Tschannen, Santosh S. Atanur, Giuseppe Bianchi, Lorena Citterio, Thomas M. Keane, Bina Joe, Oliver Hummel, Enrico Petretto, Anne E. Kwitek, Wei-Wei Chen, Norbert Hubner, Klio Maratou, Howard J. Jacob, Allison B. Sarkis, Victor Guryev, Michael R. Garrett, Man Chun John Ma, Maxime Rotival, Martin W. McBride

Publikováno v: Atanur, S, Diaz, A G, Maratou, K, Sarkis, A, Rotival, M, Game, L, Tschannen, M, Kaisaki, P, Otto, G, Ma, M C J, Keane, T, Hummel, O, Saar, K, Chen, W, Guryev, V, Gopalakrishnan, K, Garrett, M, Joe, B, Citterio, L, Bianchi, G, Mcbride, M, Dominiczak, A, Adams, D, Serikawa, T, Flicek, P, Cuppen, E, Hubner, N, Petretto, E, Gauguier, D, Kwitek, A, Jacob, H & Aitman, T 2013, ' Genome Sequencing Reveals Loci under Artificial Selection that Underlie Disease Phenotypes in the Laboratory Rat ', Cell, vol. 154, no. 3, pp. 691-703 . https://doi.org/10.1016/j.cell.2013.06.040
Cell, 154(3), 691-703. CELL PRESS
Cell
Cell, 154(3), 691-703. Elsevier B.V.

Summary Large numbers of inbred laboratory rat strains have been developed for a range of complex disease phenotypes. To gain insights into the evolutionary pressures underlying selection for these phenotypes, we sequenced the genomes of 27 rat strai

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Characterization of the genomic structure and function of regions influencing renin and angiogenesis in the SS rat

Autor: Timothy J. Stodola, Andrew S. Greene, Micheline Resende, Norbert Huebner, Carol Moreno, Howard J. Jacob, Oliver Hummel, Allison B. Sarkis, Daniela N. Didier, Kathrin Saar

Publikováno v: Physiological Genomics. 43:808-817

Impaired regulation of renin in Dahl salt-sensitive rats (SS/JRHsdMcwi, SS) contributes to attenuated angiogenesis in this strain. This study examined angiogenic function and genomic structure of regions surrounding the renin gene using subcongenic s

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https://doi.org/10.1152/physiolgenomics.00171.2010

Genetic basis of the impaired renal myogenic response in FHH rats

Autor: Jan M. Williams, Howard J. Jacob, Richard J. Roman, Marilyn Burke, Fan Fan, Malikarjuna R. Pabbidi, Jozef Lazar, Allison B. Sarkis, Ruisheng Liu, Ying Ge

Publikováno v: American journal of physiology. Renal physiology. 304(5)

This study examined the effect of substitution of a 2.4-megabase pair (Mbp) region of Brown Norway (BN) rat chromosome 1 (RNO1) between 258.8 and 261.2 Mbp onto the genetic background of fawn-hooded hypertensive (FHH) rats on autoregulation of renal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6ad78d40ab151997e520afa4b8cff0
https://pubmed.ncbi.nlm.nih.gov/23220727