Výsledky vyhledávání - "B. S. Szwergold"

Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo

Autor: B S, Szwergold, S, Howell, P J, Beisswenger

Publikováno v: Diabetes. 50(9)

Nonenzymatic glycation appears to be an important factor in the pathogenesis of diabetic complications. Key early intermediates in this process are fructosamines, such as protein-bound fructoselysines. In this report, we describe the purification and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a41436645596b7990f5316fddb351be6
https://pubmed.ncbi.nlm.nih.gov/11522682

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Glycated proteins in diabetes

Autor: P J, Beisswenger, B S, Szwergold, K T, Yeo

Publikováno v: Clinics in laboratory medicine. 21(1)

The term nonenzymatic glycation (of protein) refers to a wide variety of spontaneous reactions between reducing sugars and protein-bound amines. This reaction has been documented in humans and plays a role in the development of diabetic complications

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1a1fe054cae7e06bba3e7e31a9609d7b
https://pubmed.ncbi.nlm.nih.gov/11321937

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Quantitation of resonances in biological 31P NMR spectra via principal component analysis: potential and limitations

Autor: A C, Kuesel, R, Stoyanova, N R, Aiken, C W, Li, B S, Szwergold, C, Shaller, T R, Brown

Publikováno v: NMR in biomedicine. 9(3)

This paper examines the potential and limitations of peak area quantitation of biological NMR spectra using principal component analysis (PCA), including its requirement for prior knowledge. The principles of the method are presented without in-depth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c974c30671df6c6e295d4fc792565f51
https://pubmed.ncbi.nlm.nih.gov/8892395

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Production of fructose and fructose-3-phosphate in maturing rat lenses

Autor: S, Lal, B S, Szwergold, A H, Taylor, W C, Randall, F, Kappler, T R, Brown

Publikováno v: Investigative ophthalmologyvisual science. 36(5)

A large increase in glycation of crystallins between 1 and 8 months has been demonstrated in lenses obtained from aging rats. The objective of this study was to investigate if an age-associated increase in the levels of any of the phosphorylated and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f3029b6593bd420c5a0a91fa7af6b8f
https://pubmed.ncbi.nlm.nih.gov/7706047

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Detection of fructose-3-phosphokinase activity in intact mammalian lenses by 31P NMR spectroscopy

Autor: S, Lal, B S, Szwergold, F, Kappler, T, Brown

Publikováno v: The Journal of biological chemistry. 268(11)

Recently we have identified two novel phosphorylated metabolites in the lenses of diabetic rats as sorbitol 3-phosphate (Sor-3-P) and fructose 3-phosphate (Fru-3-P). The latter compound is of particular interest since it is a potent glycating agent,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f0c02c6ca4b591eb8a04c686454cfd7
https://pubmed.ncbi.nlm.nih.gov/8385119

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Identification of a putative tumor marker in breast and colon cancer

Autor: B, Su, F, Kappler, B S, Szwergold, T R, Brown

Publikováno v: Cancer research. 53(8)

Application of a recently developed phospholipid saponification procedure to malignant colon or breast tissue produces an unidentified phosphodiester resonance in the 31P nuclear magnetic resonance spectrum which appears to correlate with malignancy.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87d632f488e49e6b8b00f46c290a0b2c
https://pubmed.ncbi.nlm.nih.gov/8467492

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Human retinal pigment epithelial cells cultured in hyperglycemic media accumulate increased amounts of glycosaminoglycan precursors

Autor: C W, Marano, B S, Szwergold, F, Kappler, T R, Brown, F M, Matschinsky

Publikováno v: Investigative ophthalmologyvisual science. 33(9)

Confluent human retinal pigmented epithelial cells were cultured on microcarrier beads in the presence of 5.6 or 26 mmol/l glucose with or without the aldose-reductase inhibitor Sorbinil (200 microM) for 2 wk. At the end of the incubation period, per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a12965a4f0288578ac27dab8e9a7db6
https://pubmed.ncbi.nlm.nih.gov/1639609

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Identification of sorbitol 3-phosphate and fructose 3-phosphate in normal and diabetic human erythrocytes

Autor: A, Petersen, B S, Szwergold, F, Kappler, M, Weingarten, T R, Brown

Publikováno v: The Journal of biological chemistry. 265(29)

Using 31P NMR spectroscopy, we have identified sorbitol 3-phosphate and fructose 3-phosphate in normal human erythrocytes wherein their concentrations are estimated to be 13 mumol/liter cells. Incubation of hemolysates with sorbitol, fructose and ATP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a3f1e856c37cff787b7f52096850ac6b
https://pubmed.ncbi.nlm.nih.gov/2211634

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