Zobrazeno 1 - 10 of 21 pro vyhledávání: '"B. S. Sproat"'
1
In vitro reconstitution of mammalian U2 and U5 snRNPs active in splicing: Sm proteins are functionally interchangeable and are essential for the formation of functional U2 and U5 snRNPs
Autor: C L Will, B S Sproat, Reinhard Lührmann, V Ségault
Publikováno v: The EMBO Journal. 14:4010-4021
An in vitro reconstitution/splicing complementation system has been developed which has allowed the investigation of the role of mammalian U2 and U5 snRNP components in splicing. U2 or U5 snRNP cores are first reconstituted from purified native snRNP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89440d26e46524dec45c3e2f518cd622
https://doi.org/10.1002/j.1460-2075.1995.tb00072.x
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3
Influence of transfer RNA tertiary structure on aminoacylation efficiency by glutaminyl and cysteinyl-tRNA synthetases
Autor: L D, Sherlin, T L, Bullock, K J, Newberry, R S, Lipman, Y M, Hou, B, Beijer, B S, Sproat, J J, Perona
Publikováno v: Journal of molecular biology. 299(2)
The position of the tertiary Levitt pair between nucleotides 15 and 48 in the transfer RNA core region suggests a key role in stabilizing the joining of the two helical domains, and in maintaining the relative orientations of the D and variable loops
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3afc4993a78a7a555a9fb3ad3ac0b3a
https://pubmed.ncbi.nlm.nih.gov/10860750
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4
Synthetic Catalytic Oligonucleotides Based on the Hammerhead Ribozyme
Autor: B. S. Sproat
Publikováno v: Nucleic Acids and Molecular Biology ISBN: 9783540626794
The discovery that certain small RNA molecules found in nature, viz. plant viroids, virusoids, and satellite RNAs, undergo spontaneous self-cleavage, has led to the design of short oligoribonucleotides that are able to function in trans as specific e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd107855a4ead48a3e8bb12abae0ebbb
https://doi.org/10.1007/978-3-642-61202-2_15
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5
Target-specific arrest of mRNA translation by antisense 2'-O-alkyloligoribonucleotides
Autor: Hans E. Johansson, Matthias W. Hentze, Graham J. Belsham, B. S. Sproat
Publikováno v: Nucleic acids research. 22(22)
We describe a novel experimental approach to investigate mRNA translation. Antisense 2'-O-allyl oligoribonucleotides (oligos) efficiently arrest translation of targeted mRNAs in rabbit reticulocyte lysate and wheat germ extract while displaying minim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1657e50c96aa2aca33d7d736556ac6d4
https://pubmed.ncbi.nlm.nih.gov/7984406
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6
Comparative evaluation of seven oligonucleotide analogues as potential antisense agents
Autor: François Morvan, Jean-Louis Imbach, Alain Pompon, Isabelle Lefebvre, B. S. Sproat, B. Lebleu, Bernard Rayner, G. Degols, H. Porumb, Claude Malvy
Publikováno v: Journal of medicinal chemistry. 36(2)
12-Mer analogues, representative of seven different classes of structurally modified oligonucleotides and complementary to the same target, have been compared for their binding affinity for both single-stranded DNA and RNA, resistance to hydrolysis b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be2d11fdda4bf2a8d81fb4743d42b4e
https://pubmed.ncbi.nlm.nih.gov/8423598
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8
2'-O-alkyloligoribonucleotides, synthesis and applications in molecular biology
Autor: B S, Sproat, A I, Lamond, R G, Garcia, B, Beijer, U, Pieles, M, Douglas, K, Bohmann, M, Carmo-Fonseco, S, Weston, S, O'Loughlin
Publikováno v: Nucleic acids symposium series. (24)
Oligo(2'-O-alkylribonucleotides) have been synthesized in which alkyl is methyl, allyl and butyl. The various phosphoramidite monomers of 2'-O-alkyl uridine, cytidine, adenosine, guanosine, inosine and 2,6-diaminopurine riboside have been synthesized
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f153ce3bd20ad6ea21aaeaeba5f7fb5
https://pubmed.ncbi.nlm.nih.gov/1841381
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9
Rapid Synthesis of Oligodeoxyribonucleotides VIII.1An Improved Procedure for Solid-Phase Oligodeoxyribonucleotide Synthesis Using a Controlled Pore Glass Support and Phosphotriester Chemistry
Autor: B S Sproat, C Minganti, Michael J. Gait
Publikováno v: Nucleosides and Nucleotides. 4:139-142
An improved method for solid phase oligodeoxyribonucleotide synthesis is described that uses phosphotriester chemistry, controlled pore glass as support, a new and more stable linkage agent and a better protecting group combination.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c3c05e0390e98f3261b2881917447e5
https://doi.org/10.1080/07328318508077838
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10
Evidence for an associative mechanism in the phosphoryl transfer step catalyzed by rabbit muscle creatine kinase
Autor: G Lowe, B S Sproat
Publikováno v: Journal of Biological Chemistry. 255:3944-3951
Creatine kinase does not catalyze the scrambling of 18O in adenosine 5'-[alpha beta-18O, beta-18O2]triphosphate in the absence of creatine, in the presence of L-arginine or taurocyamine (competitive inhibitors of creatine), or in the presence of poor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecf6689d0b9307b01570cb5717940f11
https://doi.org/10.1016/s0021-9258(19)85617-x
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