Zobrazeno 1 - 10
of 12
pro vyhledávání: '"B. S. Orlek"'
Publikováno v:
Protein Engineering Design and Selection. 11:95-99
A series of highly toxic snail venoms, the omega-conotoxins, have been shown to bind selectively, and often irreversibly to the N-type voltage-gated calcium channel alpha-1 subunit. The most potent of these is known as omega-conotoxin GVIA from the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2b230dc86cdd8225a5602c34c50815
https://doi.org/10.1093/protein/11.2.95
https://doi.org/10.1093/protein/11.2.95
Publikováno v:
Synthetic Communications. 23:487-494
The controlled addition of nucleophiles to (trimethylsilyl) ethynyl ketones provides a facile route to β-ketoacetals, β-alkoxy-α,β-unsaturated ketones or vinylogous amides depending on the choice of reaction conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f310a386f4522c6de82adea5ecb963b2
https://doi.org/10.1080/00397919308009803
https://doi.org/10.1080/00397919308009803
Autor:
B. S. ORLEK, D. LIGHTOWLER
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb65231102206e25f2ade8a0e6eb82f6
https://doi.org/10.1002/chin.199342200
https://doi.org/10.1002/chin.199342200
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71d6e860122f0d30be999315be6f8b85
https://doi.org/10.1002/chin.199414064
https://doi.org/10.1002/chin.199414064
Autor:
B. S. Orlek
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76ba73267f2b2f47b34d65a445cd17fd
https://doi.org/10.1002/chin.199636096
https://doi.org/10.1002/chin.199636096
Autor:
E. A. Crowe, B. S. Orlek
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9052d09ec6bb052973ebc7db1632859b
https://doi.org/10.1002/chin.199806193
https://doi.org/10.1002/chin.199806193
Autor:
J M, Loudon, S M, Bromidge, F, Brown, M S, Clark, J P, Hatcher, J, Hawkins, G J, Riley, G, Noy, B S, Orlek
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(3)
The finding that ascending cholinergic systems are severely degenerated in Alzheimer's disease has driven the search for a cholinomimetic therapy. Adverse effects observed with cholinesterase inhibitors and high-efficacy muscarinic agonists led us to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3b42546b9eda390cfeee3e533081b65e
https://pubmed.ncbi.nlm.nih.gov/9399977
https://pubmed.ncbi.nlm.nih.gov/9399977
Publikováno v:
Biochemical Journal. 187:797-802
The kinetics of the inactivation of beta-lactamase I from Bacillus cereus 569 by preparations of 6 alpha-bromopenicillanic acid showed unexpected features. These can be quantitatively accounted for on the basis of the inactivator being the epimer, 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb45f59e47ae344956d8fc05b503e32
https://doi.org/10.1042/bj1870797
https://doi.org/10.1042/bj1870797
Publikováno v:
Biochemical Journal. 177:365-367
The inactivation of beta-lactamase I by preparations of 6alpha-bromopenicillanic acid showed unexpected kinetic features that indicated that the active species was the 6beta-epimer. Samples containing 6beta-bromopenicillanic acid have been synthesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bac991af178a9d8470c760ab2c38e29
https://doi.org/10.1042/bj1770365
https://doi.org/10.1042/bj1770365
Publikováno v:
Chemischer Informationsdienst. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20dbf37672d7bbbca96beac32ba20fb4
https://doi.org/10.1002/chin.197607327
https://doi.org/10.1002/chin.197607327