Zobrazeno 1 - 10
of 145
pro vyhledávání: '"B. Radke"'
Autor:
Nicholas Rinkenberger, Alex Rosenberg, Joshua B. Radke, Jaya Bhushan, Tadakimi Tomita, Louis M. Weiss, L. David Sibley
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTAutophagy contributes to innate immunity by targeting intracellular pathogens for elimination. Previous studies identified a non-canonical autophagy pathway that controls Toxoplasma gondii infection in a strain-dependent manner in interferon
Externí odkaz:
https://doaj.org/article/403ad9e259624f7c9a296a7404b85e69
Autor:
Joshua B. Radke, Bruno Melillo, Payal Mittal, Manmohan Sharma, Amit Sharma, Yong Fu, Taher Uddin, Arthur Gonse, Eamon Comer, Stuart L. Schreiber, Anil K. Gupta, Arnab K. Chatterjee, L. David Sibley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Current treatments for toxoplasmosis are limited by adverse reactions and inability to cure chronic infections dominated by semi-dormant cyst forms. Here the authors demonstrate the potential of small molecule inhibitors of PheRS for controlling acut
Externí odkaz:
https://doaj.org/article/54f3e31953f543ac83275cd23bb755ea
Publikováno v:
Toxicology Reports, Vol 6, Iss , Pp 1040-1046 (2019)
Hydroxychloroquine is a medication used to treat autoimmune conditions. Overdoses of hydroxychloroquine are uncommon, with most recommendations on monitoring drawing from experience with more common overdoses of the related drug chloroquine. We prese
Externí odkaz:
https://doaj.org/article/e047a611f8a5465290d1813f8aff30eb
Autor:
Jaya Bhushan, Joshua B. Radke, Yi-Chieh Perng, Michael Mcallaster, Deborah J. Lenschow, Herbert W. Virgin, L. David Sibley
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT The intracellular protozoan parasite Toxoplasma gondii is capable of infecting most nucleated cells, where it survives in a specially modified compartment called the parasitophorous vacuole (PV). Interferon gamma (IFN-γ) is the major cytoki
Externí odkaz:
https://doaj.org/article/076f57152f6140a48b7e5dad96971507
Publikováno v:
Data in Brief, Vol 27, Iss , Pp - (2019)
Hydroxychloroquine is a medication used to treat rheumatoid arthritis, systemic lupus erythematosus, and other autoimmune disorders. Previous studies have shown that hydroxychloroquine and the structurally related drug chloroquine have the potential
Externí odkaz:
https://doaj.org/article/471c07af2edf47218a7f3dafa01ed85b
Autor:
Joshua B. Radke, Douglas A. Algren, James A. Chenoweth, Kelly P. Owen, Jonathan B. Ford, Timothy E. Albertson, Mark E. Sutter
Publikováno v:
Western Journal of Emergency Medicine, Vol 19, Iss 4 (2018)
Introduction: Rhabdomyolysis and delayed acetaminophen hepatotoxicity may be associated with elevated serum transaminase values. Establishing the cause of elevated transaminases may be especially difficult because of limited or inaccurate histories o
Externí odkaz:
https://doaj.org/article/0d896c5217b441e3a6d383c85517842e
Autor:
Joshua B Radke, Danielle Worth, David Hong, Sherri Huang, William J Sullivan, Emma H Wilson, Michael W White
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007035 (2018)
Tachyzoite to bradyzoite development in Toxoplasma is marked by major changes in gene expression resulting in a parasite that expresses a new repertoire of surface antigens hidden inside a modified parasitophorous vacuole called the tissue cyst. The
Externí odkaz:
https://doaj.org/article/ace1116a0b0e43b2addd43ffc479cd52
Autor:
Sherri Huang, Michael J. Holmes, Joshua B. Radke, Dong-Pyo Hong, Ting-Kai Liu, Michael W. White, William J. Sullivan
Publikováno v:
mSphere, Vol 2, Iss 2 (2017)
ABSTRACT Toxoplasma gondii is a protozoan parasite of great importance to human and animal health. In the host, this obligate intracellular parasite persists as a tissue cyst that is imperceptible to the immune response and unaffected by current ther
Externí odkaz:
https://doaj.org/article/45c1ca02eef54ef589b238165f1c8c0e
Publikováno v:
mSphere, Vol 2, Iss 1 (2017)
ABSTRACT The Toxoplasma biology that underlies human chronic infection is developmental conversion of the acute tachyzoite stage into the latent bradyzoite stage. We investigated the roles of two alkaline-stress-induced ApiAP2 transcription factors,
Externí odkaz:
https://doaj.org/article/ab29d7617fd34e07b1032b58e9a5efd0
Publikováno v:
The American journal of forensic medicine and pathology. 43(3)
Although there are multiple therapeutic uses for colchicine, it is particularly dangerous in the setting of overdose due to an irreversible mechanism of action combined with a narrow therapeutic window. Colchicine is an antimitotic agent that binds t