Intravesical BCG: Possible Protective Impact Against COVID-19 in NMIBC Patients

Autor: Gabriel GLUCK, B. RADU, Angelica IONESCU, A. BOAR, Ioanel SINESCU

Publikováno v: Modern Medicine, Vol 27, Iss 2, Pp 103-106 (2020)

Purpose: To determine the incidence of COVID 19 in a series of registered patients with non-muscle invasive bladder cancer, treated by TUR-BT and intravesical BCG. Patients and method: We analysed 127 patients with nonmuscle invasive bladder cancer,

Externí odkaz: https://doaj.org/article/e0c7eda94b134ec88274a070e0155e2a

Optical chemosensors for the detection of proximally phosphorylated peptides and proteins

Autor: Aaron D. Cabral, Patrick T. Gunning, Elvin D. de Araujo, Tudor B. Radu

Publikováno v: RSC Chemical Biology

Proximal multi-site phosphorylation is a critical post-translational modification in protein biology. The additive effects of multiple phosphosite clusters in close spatial proximity triggers integrative and cooperative effects on protein conformatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09d75ba1d01c7696823ce2c2b7444c4
https://doi.org/10.1039/d1cb00055a

Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype

Autor: Andrew E. Shouksmith, Abootaleb Sedighi, Yasir S. Raouf, Niyati Kachhiyapatel, Ayah Abdeldayem, Paris R. Watson, Krimo Toutah, Olasunkanmi O. Olaoye, David W. Christianson, Patrick T. Gunning, Shazreh Bukhari, Pimyupa Manaswiyoungkul, Justyna M. Gawel, Aaron D. Cabral, Johan Israelian, Muhammad Murtaza Hassan, Nabanita Nawar, Fettah Erdogan, Elvin D. de Araujo, Tudor B. Radu, Mulu Geletu

Publikováno v: J Med Chem

Histone deacetylase 6 (HDAC6) is involved in multiple regulatory processes, ranging from cellular stress to intracellular transport. Inhibition of aberrant HDAC6 activity in several cancers and neurological diseases has been shown to be efficacious i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9badc9098e407d7f5ed776a4126d1106
https://pubmed.ncbi.nlm.nih.gov/33576627

Molecular hydrogen in minerals as a clue to interpret ∂D variations in the mantle

Autor: Nathalie Bolfan-Casanova, Etienne Deloule, Dmitri A. Ionov, Bertrand Moine, I. B. Radu, Alexander V. Golovin, Gelu Costin, Andrey V. Korsakov, Jean-Yves Cottin, O. B. Oleinikov

Publikováno v: Nature Communications
Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-17442-8⟩
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-17442-8⟩

Trace amounts of water dissolved in minerals affect density, viscosity and melting behaviour of the Earth’s mantle and play an important role in global tectonics, magmatism and volatile cycle. Water concentrations and the ratios of hydrogen isotope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cd38194a02df743b931c22e3639e0e
https://doi.org/10.1038/s41467-020-17442-8

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