Zobrazeno 1 - 10 of 13 pro vyhledávání: '"B. R. Danielsson"'
1
Stage-specific skeletal and visceral defects of the I(Kr)-blocker almokalant: further evidence for teratogenicity via a hypoxia-related mechanism
Autor: A C, Sköld, K, Wellfelt, B R, Danielsson
Publikováno v: Teratology. 64(6)
As a class effect, potent I(Kr)-blockers have been shown to induce stage-specific external malformations. The aim of this study was to investigate whether I(Kr)-blockers also induce stage-specific visceral and skeletal defects and to further elucidat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3fe554dd3599382dadcbc01957bc18d4
https://pubmed.ncbi.nlm.nih.gov/11754171
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2
Developmental toxicity in the pregnant rabbit by the class III antiarrhythmic drug sotalol
Autor: A C, Sköld, B R, Danielsson
Publikováno v: Pharmacologytoxicology. 88(1)
The purpose of this study was to investigate the potential of sotalol to cause developmental toxicity in the pregnant rabbit. Sotalol is a beta-adrenoceptor blocking drug which also has class III antiarrhythmic properties via Ikr channel blockade. EX
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::52ca385a5dac636fe0361e75c739c575
https://pubmed.ncbi.nlm.nih.gov/11169159
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3
Developmental toxicity of the class III antiarrhythmic agent almokalant in mice. Adverse effects mediated via induction of embryonic heart rhythm abnormalities
Autor: A C, Sköld, B R, Danielsson
Publikováno v: Arzneimittel-Forschung. 50(6)
Almokalant (ALM, CAS 123955-10-2), a class III antiarrhythmic drug, has been shown to be embryotoxic in rats. In the absence of human pregnancy outcome data, the human relevance of these findings in rats is unknown, and results from other species wou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f88b21532b5c579271adf5d02dbb2543
https://pubmed.ncbi.nlm.nih.gov/10918943
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4
Pharmacologically induced embryonic dysrhythmia and episodes of hypoxia followed by reoxygenation: a common teratogenic mechanism for antiepileptic drugs?
Autor: F, Azarbayjani, B R, Danielsson
Publikováno v: Teratology. 57(3)
Antiepileptic drugs (AEDs), such as phenytoin (PHT), carbamazepine (CBZ), trimethadione (TMD), and phenobarbital (PB), have all been associated with a similar pattern of malformations, as well as growth retardation and developmental delay. Valproic a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba5615620bc415180d234b7258bd4666
https://pubmed.ncbi.nlm.nih.gov/9587965
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5
Initiation of phenytoin teratogenesis: pharmacologically induced embryonic bradycardia and arrhythmia resulting in hypoxia and possible free radical damage at reoxygenation
Autor: B R, Danielsson, F, Azarbayjani, A C, Sköld, W S, Webster
Publikováno v: Teratology. 56(4)
The aim of this study was to investigate if phenytoin has the capacity to induce embryonic hypoxia mediated via adverse effects on the embryonic heart. Mouse embryos of different strains (CD-1, C57B1/6J and A/J) as well as Sprague Dawley (SD) rat emb
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ce81bfa8539abeed94da075787b2d471
https://pubmed.ncbi.nlm.nih.gov/9408978
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6
[Epilepsy and pregnancy. Balancing between risks to the mother and child]
Autor: T, Tomson, B R, Danielsson, B, Winbladh
Publikováno v: Lakartidningen. 94(34)
Pregnancy may be especially problematic for the epileptic woman, obstetric complications tend to be more frequent, and seizure control and the pharmacokinetics of anticonvulsants may be affected. The risk of seizures is particularly high during labou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b417626e9f9cf1906d3361e515a127f
https://pubmed.ncbi.nlm.nih.gov/9303993
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7
Teratogenic potential of almokalant, dofetilide, and d-sotalol: drugs with potassium channel blocking activity
Autor: W S, Webster, P D, Brown-Woodman, M D, Snow, B R, Danielsson
Publikováno v: Teratology. 53(3)
Drugs with class III antiarrhythmic activity are potential human teratogens because of their ability to cause bradycardia in the embryo during the organogenic period. Three drugs with class III antiarrhythmic activity, almokalant, dofetilide and d-so
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e28ee5540c7dbd081273b3e0e7a3fbcf
https://pubmed.ncbi.nlm.nih.gov/8761884
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9
Reproductive toxicity studies of the antihypertensive agent felodipine in the rat
Autor: M K, Danielson, B R, Danielsson
Publikováno v: Arzneimittel-Forschung. 43(2)
Felodipine (4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylic acid 5-ethyl 3-methyl ester, CAS 72509-76-3), a vascular selective dihydropyridine calcium antagonist, was tested in three different reproduction studies in the rat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc1b19c844f00dcb1e96b85db04fc80c
https://pubmed.ncbi.nlm.nih.gov/8457234
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