Zobrazeno 1 - 10
of 12
pro vyhledávání: '"B. R. Conklin"'
Autor:
S. E. Salomonsson, A. M. Maltos, K. Gill, O. Aladesuyi Arogundade, K. A. Brown, A. Sachdev, M. Sckaff, K. J. K. Lam, I. J. Fisher, R. S. Chouhan, V. S. Van Laar, C. B. Marley, I. McLaughlin, K. S. Bankiewicz, Y.-C. Tsai, B. R. Conklin, C. D. Clelland
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract A repeat expansion mutation in the C9orf72 gene is the leading known genetic cause of FTD and ALS. The C9orf72-ALS/FTD field has been plagued by a lack of reliable tools to monitor this genomic locus and its RNA and protein products. We have
Externí odkaz:
https://doaj.org/article/782f10f759d84e6aa3c479b903db9782
Science museums play an important role in science education, both engaging the public with science concepts and building support for scientific research. Designing museum exhibits to meet increasing public interests in the life sciences is particular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a5de63fea96b95fbdc065b4ba5a903f
https://doi.org/10.1101/2021.04.19.440451
https://doi.org/10.1101/2021.04.19.440451
Publikováno v:
Investigative ophthalmologyvisual science. 41(13)
To develop a system for inducible photoreceptor-specific gene expression in transgenic mice. The tetracycline regulatory system was chosen because it possesses the useful property of direct control of gene expression through use of an exogenous agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a9a8a153ab96aabc8ea06753d006cc3
https://pubmed.ncbi.nlm.nih.gov/11095627
https://pubmed.ncbi.nlm.nih.gov/11095627
Autor:
B R, Conklin, P, Herzmark, S, Ishida, T A, Voyno-Yasenetskaya, Y, Sun, Z, Farfel, H R, Bourne
Publikováno v:
Molecular pharmacology. 50(4)
The carboxyl terminus of the G protein alpha subunit is a key determinant of the fidelity of receptor activation. We have previously shown that the Gq alpha subunit (alpha q) can be made to respond to alpha i-coupled receptors by replacing its carbox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54c912b4f1bb9790647b4d6b150193aa
https://pubmed.ncbi.nlm.nih.gov/8863834
https://pubmed.ncbi.nlm.nih.gov/8863834
Publikováno v:
The Journal of biological chemistry. 269(7)
Activity of the ubiquitous Na-H exchanger (NHE1) is regulated by a number of receptors with tyrosine kinase activity as well as by several classes of receptors coupled to heterotrimeric GTP-binding proteins. We previously demonstrated that the beta 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9f958168fe064f5f36a24bfcc377d6d
https://pubmed.ncbi.nlm.nih.gov/8106440
https://pubmed.ncbi.nlm.nih.gov/8106440
Publikováno v:
The Journal of biological chemistry. 268(19)
Agonists for Gi-coupled receptors augment Gs-stimulated cAMP synthesis in human embryonic kidney (HEK) 293 cells transiently expressing the type II isozyme of adenylylcyclase (AC-II). This augmentation, mediated by beta gamma subunits released from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a600c983c78bbca4b75cb03a755b875f
https://pubmed.ncbi.nlm.nih.gov/8390980
https://pubmed.ncbi.nlm.nih.gov/8390980
Autor:
B R, Conklin, H R, Bourne
Publikováno v:
Cell. 73(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb80c354574fb75b0c9eb7cf547ba160
https://pubmed.ncbi.nlm.nih.gov/8388779
https://pubmed.ncbi.nlm.nih.gov/8388779
Publikováno v:
Nature. 363(6426)
Agonist-bound receptors activate heterotrimeric (alpha beta gamma) G proteins by catalysing replacement of GDP bound to the alpha-subunit by GTP. mutations in the C terminus of the alpha-subunit, its covalent modification by pertussis toxin-catalysed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb127700dd6d03ba1d10930cefa00aa0
https://pubmed.ncbi.nlm.nih.gov/8387644
https://pubmed.ncbi.nlm.nih.gov/8387644
Publikováno v:
Nature. 356(6365)
Agonist-bound receptors activate heterotrimeric (alpha beta gamma) G proteins by catalysing replacement by GTP of GDP bound to the alpha subunit, resulting in dissociation of alpha-GTP from the beta gamma subunits. In most cases, alpha-GTP carries th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fb44e791a6e63c5a2f9cbadcc8865c1
https://pubmed.ncbi.nlm.nih.gov/1312225
https://pubmed.ncbi.nlm.nih.gov/1312225
Autor:
B R, Conklin
Publikováno v:
JAMA. 252(22)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ee46ae9bd29445b91546aac1cae8cce
https://pubmed.ncbi.nlm.nih.gov/6502880
https://pubmed.ncbi.nlm.nih.gov/6502880