Zobrazeno 1 - 10
of 114
pro vyhledávání: '"B. R. Bloom"'
Publikováno v:
The Journal of Immunology. 163:558-561
Signaling by extracellular nucleotides through P2 purinergic receptors affects diverse macrophage functions; however, its role in regulating antimicrobial radicals during bacterial infection has not been investigated. Mycobacterium tuberculosis-infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c13c7c2a84a1dbed416a4b5e285d634
https://doi.org/10.4049/jimmunol.163.2.558
https://doi.org/10.4049/jimmunol.163.2.558
Autor:
V E García, P A Sieling, J Gong, P F Barnes, K Uyemura, Y Tanaka, B R Bloom, C T Morita, R L Modlin
Publikováno v:
The Journal of Immunology. 159:1328-1335
TCR gamma delta T cells are considered important in the rapid immune response to intracellular infection. We investigated the early response of peripheral blood gamma delta T cells to the nonpeptide Ag isopentenyl pyrophosphate and to its synthetic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49abe42b8bdca6d2ecc6c13b1636a9ca
https://doi.org/10.4049/jimmunol.159.3.1328
https://doi.org/10.4049/jimmunol.159.3.1328
Autor:
J Kim, A Sette, S Rodda, S Southwood, P A Sieling, V Mehra, J D Ohmen, J Oliveros, E Appella, Y Higashimoto, T H Rea, B R Bloom, R L Modlin
Publikováno v:
The Journal of Immunology. 159:335-343
The 10-kDa protein Ag of Mycobacterium leprae, a human GroES hsp10 cognate, is a major T cell Ag in human leprosy infection. We investigated the mechanism for T cell responsiveness to this Ag according to the trimolecular interaction between T cell,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f3cc03347526efdafa5ec3d69db6e80
https://doi.org/10.4049/jimmunol.159.1.335
https://doi.org/10.4049/jimmunol.159.1.335
Publikováno v:
The Journal of Immunology. 158:1217-1221
Although a role for gammadelta receptor-bearing T cells in the acquired immune response to infection with Mycobacterium tuberculosis is suggested by several lines of evidence, the only data indicating a possible role in specific protective immunity h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dae7d71587a93ef8a56a4ffb14084496
https://doi.org/10.4049/jimmunol.158.3.1217
https://doi.org/10.4049/jimmunol.158.3.1217
Publikováno v:
The Journal of Immunology. 155:2515-2524
IL-12, a cytokine produced by macrophages and B cells, has recently been found to exert pleiotropic effects on the immune system. When BALB/c mice, a strain highly susceptible to virulent Mycobacterium tuberculosis infection, were given IL-12 at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::732856f37dbb40c3f1cbc39d54959907
https://doi.org/10.4049/jimmunol.155.5.2515
https://doi.org/10.4049/jimmunol.155.5.2515
Publikováno v:
The Journal of Immunology. 154:998-1006
The predominant subpopulation of gamma delta T cells in human peripheral blood expresses TCR V region genes V gamma 2 paired with V delta 2. Previous studies have shown that these V gamma 2V delta 2+ T cells proliferate in response to Daudi Burkitt l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d92fa142ecf7221e455e89fa355eb0b
https://doi.org/10.4049/jimmunol.154.3.998
https://doi.org/10.4049/jimmunol.154.3.998
Publikováno v:
The Journal of Immunology. 150:5501-5510
IL-10 and IL-4 have been shown to exert an inhibitory effect on cell-mediated immune responses. Our previous studies of leprosy demonstrated that IL-10 and IL-4 mRNA were preferentially expressed in lesions from lepromatous patients, those immunologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dce065c906eb10300d25ee5b0e738d88
https://doi.org/10.4049/jimmunol.150.12.5501
https://doi.org/10.4049/jimmunol.150.12.5501
Publikováno v:
The Journal of Immunology. 149:1470-1475
Reactional states in leprosy are produced by different immunologic mechanisms and are responsible for a major component of tissue damage of the disease. Reversal reactions exhibit increased CD4 T cell infiltration in lesions and augmented cell-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::553c67c04dee80e28c46296498ad074e
https://doi.org/10.4049/jimmunol.149.4.1470
https://doi.org/10.4049/jimmunol.149.4.1470
Autor:
P F Barnes, V Mehra, B Rivoire, S J Fong, P J Brennan, M S Voegtline, P Minden, R A Houghten, B R Bloom, R L Modlin
Publikováno v:
The Journal of Immunology. 148:1835-1840
Identification of Ag of Mycobacterium tuberculosis recognized by T cells is essential to understanding the pathogenesis of tuberculosis and mechanism(s) of resistance to infection. Previous studies evaluating the immunoreactivity of nitrocellulose tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce8e9909b095776fb4d9cb1f1f888fa8
https://doi.org/10.4049/jimmunol.148.6.1835
https://doi.org/10.4049/jimmunol.148.6.1835
Publikováno v:
Science. 254:279-282
Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c216c0b157451e0eb4228a81e7048c44
https://doi.org/10.1126/science.254.5029.279
https://doi.org/10.1126/science.254.5029.279