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CDK/ERK-mediated phosphorylation of the human influenza A virus NS1 protein at threonine-215

Autor: Richard E. Randall, B. Precious, David A. Jackson, Richard M. Elliott, Axel Knebel, Benjamin G. Hale, Catherine H. Botting, Caroline S. Galloway

Publikováno v: Virology. 383:6-11

Posttranslational modification of viral proteins by cellular enzymes is a feature of many virus replication strategies. Here, we report that during infection the multifunctional human influenza A virus NS1 protein is phosphorylated at threonine-215.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807142bf255eddb01b2e2634c3828c08
https://doi.org/10.1016/j.virol.2008.10.002

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Mapuera virus, a rubulavirus that inhibits interferon signalling in a wide variety of mammalian cells without degrading STATs

Autor: Nicola Stock, Steve Goodbourn, B. Precious, Kathrin Hagmaier, Lin-Fa Wang, Richard E. Randall, Kay Childs

Publikováno v: The Journal of General Virology

Mapuera virus(MPRV) is a paramyxovirus that was originally isolated from bats, but its host range remains unknown. It was classified as a member of the genusRubulaviruson the basis of structural and genetic features. Like other rubulaviruses it encod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a27bd3f3c2d7567c60e477139cc214
http://europepmc.org/articles/PMC2884952

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In vitro and in vivo specificity of ubiquitination and degradation of STAT1 and STAT2 by the V proteins of the paramyxoviruses simian virus 5 and human parainfluenza virus type 2

Autor: D. F. Young, B. Precious, L. Andrejeva, Stephen Goodbourn, Richard E. Randall

Publikováno v: Journal of General Virology. 86:151-158

Previous work has documented that the V protein of simian virus 5 (SV5) targets STAT1 for proteasome-mediated degradation, whilst the V protein of human parainfluenza virus type 2 (hPIV2) targets STAT2. Here, it was shown that the processes of ubiqui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaabbe6f4cd3f3c1be7b56a96de28ba3
https://doi.org/10.1099/vir.0.80263-0

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Novel modifications to the C-terminus of LTB that facilitate site-directed chemical coupling of antigens and the development of LTB as a carrier for mucosal vaccines

Autor: Richard E. Randall, B. Precious, A.M. O'Dowd, R. Shawcross, Catherine H. Botting

Publikováno v: Vaccine. 17:1442-1453

To facilitate site-directed chemical coupling of antigens to the heat labile enterotoxin B subunit of Escherichia coli (LTB), a series of genetically modified fusion proteins of LTB were constructed. The LTB fusion proteins had modified versions of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deab3535cf98e5bcfa28f76474bc2f55
https://doi.org/10.1016/s0264-410x(98)00375-2

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Inducible expression of the P, V, and NP genes of the paramyxovirus simian virus 5 in cell lines and an examination of NP-P and NP-V interactions

Autor: D. F. Young, B Precious, Martin D. Ryan, Rachel Fearns, A Bermingham, Richard E. Randall

Publikováno v: Journal of Virology. 69:8001-8010

The P, V, and NP genes of the paramyxovirus simian virus 5 (SV5) were cloned such that their expression was regulated by the tetracycline-controlled transactivator (M. Gossen and H. Bujard, Proc. Natl. Acad. Sci. USA 89:5547-5551, 1992), and mammalia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448d80ea8d8d86735f862742224fe682
https://doi.org/10.1128/jvi.69.12.8001-8010.1995

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Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis

Autor: Dan F. Young, Richard E. Randall, Marian J. Killip, B. Precious, Steve Goodbourn

Publikováno v: The Journal of General Virology

Conflicting reports exist regarding the requirement for virus replication in interferon (IFN) induction by paramyxoviruses. Our previous work has demonstrated that pathogen-associated molecular patterns capable of activating the IFN-induction cascade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d546e00b3daf92754602910659a900
https://hdl.handle.net/10023/2451

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Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

Autor: Rupert J. Russell, David A. Jackson, Marian J. Killip, Benjamin G. Hale, Alexander Gray, Philip S. Kerry, B. Precious, Richard E. Randall

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 107(5)

Seasonal epidemics and periodic worldwide pandemics caused by influenza A viruses are of continuous concern. The viral nonstructural (NS1) protein is a multifunctional virulence factor that antagonizes several host innate immune defenses during infec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de30c8f59aaea8c8c85871dd817d2a25
https://pubmed.ncbi.nlm.nih.gov/20133840

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Sequence Analysis of the HN Gene of Parainfluenza Virus Type 2

Autor: J. A. Southern, Richard E. Randall, B. Precious

Publikováno v: Journal of General Virology. 71:1163-1168

A cDNA library was constructed in lambda gt10 using mRNA purified from cells infected with parainfluenza virus type 2 (PIV2). Virus-specific clones were identified by screening the library with 32P-labelled cDNA probes made from randomly primed vRNA.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f800213239bc674e8a3856bf6a8d7f87
https://doi.org/10.1099/0022-1317-71-5-1163

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