Zobrazeno 1 - 10 of 692 pro vyhledávání: '"B. Pernis"'
1
Akademický článek
Serotonin-1A receptor, a psychiatric disease risk factor, influences offspring immunity via sex-dependent genetic nurture
Autor: Rosa J. Chen, Anika Nabila, Swati Phalke, Danny Flores Castro, Judit Gal Toth, Paul Bergin, Jeroen Bastiaans, Heidi Stuhlmann, Alessandra B. Pernis, Miklos Toth
Publikováno v: iScience, Vol 25, Iss 12, Pp 105595- (2022)
Summary: Serotonin-1A receptor (5HT1AR) is highly expressed in corticolimbic regions and its deficit is associated with anxiety and depression. A similar reduction in 5HT1AR heterozygous knockout (Het) mice results in anxiety-like and increased stres
Externí odkaz: https://doaj.org/article/8bdba824be5b48fd9f993aee9b4e912d
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2
Akademický článek
Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice
Autor: Edd Ricker, Michela Manni, Danny Flores-Castro, Daniel Jenkins, Sanjay Gupta, Juan Rivera-Correa, Wenzhao Meng, Aaron M. Rosenfeld, Tania Pannellini, Mahesh Bachu, Yurii Chinenov, Peter K. Sculco, Rolf Jessberger, Eline T. Luning Prak, Alessandra B. Pernis
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF)
Externí odkaz: https://doaj.org/article/908466dd2bb34f6fa842dde7cbf2d877
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4
Akademický článek
The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity
Autor: Woelsung Yi, Sanjay Gupta, Edd Ricker, Michela Manni, Rolf Jessberger, Yurii Chinenov, Henrik Molina, Alessandra B. Pernis
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Excessive expansion of the T follicular helper (TFH) cell pool is associated with autoimmune disease and Def6 has been identified as an SLE risk variant. Here the authors show that Def6 limits proliferation of TFH cells in mice via alteration of mTOR
Externí odkaz: https://doaj.org/article/d8898e9c90074000ad87e4d3b1cd931c
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5
Interleukin‐13 Receptor α1–Mediated Signaling Regulates Age‐Associated /Autoimmune B Cell Expansion and Lupus Pathogenesis
Autor: Zhu Chen, Danny Flores Castro, Sanjay Gupta, Swati Phalke, Michela Manni, Juan Rivera‐Correa, Rolf Jessberger, Habib Zaghouani, Eugenia Giannopoulou, Tania Pannellini, Alessandra B. Pernis
Publikováno v: Arthritis & Rheumatology. 74:1544-1555
Age-associated/autoimmune B cells (ABCs) are an emerging B cell subset with aberrant expansion in systemic lupus erythematosus. ABC generation and differentiation exhibit marked sexual dimorphism, and Toll-like receptor 7 (TLR-7) engagement is a key
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced9a0cb9bf4b464785b75f399a6e83f
https://doi.org/10.1002/art.42146
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10
Adaptive immune responses in patients requiring revision after total knee arthroplasty
Autor: Daniel Jenkins, Swati Phalke, Richard Bell, Samantha Lessard, Sanjay Gupta, Mark Youssef, Kathleen Tam, Allina Nocon, Juan Rivera‐Correa, Timothy Wright, Thomas Sculco, Miguel Otero, Alessandra B. Pernis, Peter Sculco
Publikováno v: Journal of orthopaedic research : official publication of the Orthopaedic Research SocietyREFERENCES.
Dissatisfaction occurs in nearly 20% of patients after total knee arthroplasty (TKA); however, there remains only limited understanding of the biologic mechanisms that may contribute to suboptimal postoperative outcomes requiring revision surgery. Ex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e9e43825f085bb04dcc71c94dc78f2
https://pubmed.ncbi.nlm.nih.gov/36121317
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Plný text Recenzováno Digitální knihovna AV ČR
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