Relationship Between Pharmacokinetics and Pharmacodynamics of Eptastigmine in Young Healthy Volunteers

Autor: B. P. Imbimbo, Elisabetta Onelli, Andrea Giustina, Luigi Zecca, M. Schettino, Andrea Mosca, Massimo Licini

Publikováno v: Scopus-Elsevier

Eptastigmine is a long-lasting acetyl-cholinesterase inhibitor, currently being developed for the symptomatic treatment of Alzheimer's disease. In the present study, we investigated the relationship between pharmacokinetics and pharmacodynamics of ep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3ba9acec349f3ef5bd9c0b386c1c9c
https://doi.org/10.1002/j.1552-4604.1995.tb04060.x

Rapid potentiometric determination of cholinesterases in plasma and red cells: Application to eptastigmine monitoring

Autor: Luigi Zecca, Massimo Luzzana, Davide Radice, B. P. Imbimbo, E. Cazzola, Andrea Mosca, N. Lattuada, A. Auteri

Publikováno v: Chemico-Biological Interactions. 87:265-268

Eptastigmine (MF 201) is a new physostigmine derivative with potent inhibitory activity on cholinesterases. Here we present a new potentiometric cholinesterase activity assay suitable for MF 201 monitoring. The analysis is performed on a differential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb4d465f321685da0a66a5142bed177
https://doi.org/10.1016/0009-2797(93)90053-2

The pharmacokinetics and pharmacodynamics of dermatan sulphate MF701 during haemodialysis for chronic renal failure

Autor: F. Gianese, R.J. Berckmans, Michael T. Nurmohamed, H. R. Büller, J. W. Ten Cate, B. P. Imbimbo

Publikováno v: British journal of clinical pharmacology, 35(3), 335-339. Wiley-Blackwell
Gianese, F, Nurmohamed, M T, Imbimbo, B P, Büller, H R, Berckmans, R J & Ten Cate, J W 1993, ' The pharmacokinetics and pharmacodynamics of dermatan sulphate MF701 during haemodialysis for chronic renal failure ', British Journal of Clinical Pharmacology, vol. 35, no. 3, pp. 335-9 . https://doi.org/10.1111/j.1365-2125.1993.tb05704.x
British Journal of Clinical Pharmacology, 35(3), 335-9. Wiley-Blackwell

Single i.v. bolus doses of dermatan sulphate MF701 were administered before the onset of haemodialysis to patients with chronic renal failure, to prevent clotting in the extracorporeal circuit. Six patients received 2 mg kg-1; six were given 2.5 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc745e58e632f0cd7d4f37c55fd1c97
https://doi.org/10.1111/j.1365-2125.1993.tb05704.x

High-performance liquid chromatography and preliminary pharmacokinetics of rufloxacin and its metabolites, N-desmethylrufloxacin and rufloxacinsulfoxide, in urine of Rhesus monkey Macaca mulatta

Autor: A. Peeters, B. P. Imbimbo, Tom B. Vree, M. van den Biggelaar-Martea

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 573:168-172

A gradient high-performance liquid chromatographic method for the quantification of rufloxacin and two of its metabolites in urine, N-desmethylrufloxacin and rufloxacinsulfoxide, has been developed and validated. Monkey urine samples were diluted ten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a228cbf17d05aa069aa4d46489a7ae
https://doi.org/10.1016/0378-4347(92)80493-a

Pharmacodynamics of a long acting depot preparation of avorelin in patients with prostate cancer. Avorelin Study Group

Autor: A V, Kaisary, W G, Bowsher, D A, Gillatt, J B, Anderson, P R, Malone, B P, Imbimbo

Publikováno v: The Journal of urology. 162(6)

We evaluate the pharmacodynamics, pharmacokinetics and tolerability of a sustained release depot formulation of avorelin, a new potent super agonist of luteinizing hormone-releasing hormone receptors, in patients with prostate cancer.A total of 60 pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b20e0bc068e668d8c55167e989094bb4
https://pubmed.ncbi.nlm.nih.gov/10569560