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Corticotrophin releasing hormone: its potential for a role in human myometrium

Autor: Elizabeth A. Linton, G Asbóth, B. P. Glynn, C. P. Plested, J. R. Woodman, A. López Bernal

Publikováno v: Experimental physiology. 86(2)

Aside from its role as a hypothalamic stress hormone, corticotrophin releasing hormone (CRH) is also a placental hormone, at least in primates. Although the function of placentally derived CRH remains to be fully elucidated, elevated CRH levels have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00daccd9463c25a6c3b4e4ad030bb4ff
https://pubmed.ncbi.nlm.nih.gov/11429644

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Processing of procorticotropin-releasing hormone (pro-CRH): molecular forms of CRH in normal and preeclamptic pregnancy

Autor: I, Ahmed, B P, Glynn, A V, Perkins, M G, Castro, J, Rowe, E, Morrison, E A, Linton

Publikováno v: The Journal of clinical endocrinology and metabolism. 85(2)

This study examined the different molecular forms of CRH in normal and preeclampsia maternal plasma and protease-blocked placental extracts using antibodies to different regions of the CRH precursor, pro-CRH. In the absence of protease inhibitors, ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::951e540793bd79207fb855f59f5705ab
https://pubmed.ncbi.nlm.nih.gov/10690887

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Elevated levels of N-terminal pro-opiomelanocortin peptides in fetal sheep plasma may contribute to fetal adrenal gland development and the pre-parturient cortisol surge

Autor: Philip J. Lowry, D. A. L. Shepherd, M. K. Jeacock, B. P. Glynn, Russell J. Woods, P. W. Saphier

Publikováno v: Endocrinology. 133(3)

Parturition in sheep is initiated by a rapid rise in fetal plasma cortisol. There is some controversy as to the exact nature of the drive for this pre-partum cortisol surge and it is thought that factors other than ACTH may act in concert to stimulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de5dbfd42952c05ee7cdd137bc15d9e
https://pubmed.ncbi.nlm.nih.gov/8396021

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Biosynthesis of corticotrophin-releasing hormone (CRH) in mouse corticotrophic tumour cells expressing the human proCRH gene: intracellular storage and regulated secretion

Autor: Brooke Je, B. P. Glynn, Matthew Hannah, Maria G. Castro, P.J. Lowry, Bullman Ap

Publikováno v: Journal of molecular endocrinology. 7(2)

The mouse corticotrophic tumour cell line AtT-20 naturally synthesizes pro-opiomelanocortin (POMC) which is proteolytically processed to N-POMC(1–76), ACTH, β-lipotrophin and β-endorphin. The processed products are stored in secretory vesicles an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd060e80d2d2d0fd59b6d341d66df7f
https://pubmed.ncbi.nlm.nih.gov/1657022

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Protein kinase C-stimulated phosphorylation in vitro of a Mr 80,000 protein phosphorylated in response to phorbol esters and growth factors in intact fibroblasts. Distinction from protein kinase C and prominence in brain

Autor: B P Glynn, Lee A. Witters, P J Blackshear, L Wen

Publikováno v: Journal of Biological Chemistry. 261:1459-1469

In previous studies in intact 3T3-L1 fibroblasts and adipocytes, we demonstrated that the phosphorylation state of an acidic, multicomponent Mr 80,000 protein appeared to be a specific and useful marker for the activation state of protein kinase C (B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f36bfe020056cc9a08c1f9cda7a4d38f
https://doi.org/10.1016/s0021-9258(17)36115-x

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Autor: P J, Blackshear, L, Wen, B P, Glynn, L A, Witters

Publikováno v: The Journal of biological chemistry. 261(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c73691b63dff4bc3667082b4c2ee6121
https://pubmed.ncbi.nlm.nih.gov/3080427

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