Zobrazeno 1 - 10
of 44
pro vyhledávání: '"B. P. Doctor"'
Autor:
B. P. Doctor, Ashima Saxena, Benjamin R. Capacio, Irwin Koplovitz, Carl T. Olson, Chunyuan Luo, David E. Lenz, Douglas M. Cerasoli, Connie R. Clark, James M. Federko, Donald M. Maxwell
Publikováno v:
Chemico-Biological Interactions. :205-210
Human butyrylcholinesterase (HuBuChE), purified from outdated human plasma, is being evaluated for efficacy against nerve agents in guinea pigs and cynomolgus monkeys. Previous studies in rodents and nonhuman primates demonstrated that pretreatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74f022dd1b000b4a749c35eb99c3795
https://doi.org/10.1016/j.cbi.2005.10.025
https://doi.org/10.1016/j.cbi.2005.10.025
Autor:
Petek K. Chiang, Jacov Tal, B. P. Doctor, K. Pardhasaradhi, Peter P. McCann, G. C. Zeng, Richard K. Gordon
Publikováno v:
The FASEB Journal. 10:471-480
S-Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad of biological and biochemical events. Although it has been claimed that AdoMet itself has therapeutic benefits, it remains to be established whether it can be tak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b0bfeeb8a6e89635833d98e284a7a4d
https://doi.org/10.1096/fasebj.10.4.8647346
https://doi.org/10.1096/fasebj.10.4.8647346
Publikováno v:
Journal of Biological Chemistry. 266:7481-7487
Three distinct classes of membrane-bound acetylcholinesterases (AChEs) have been identified. A12 AChE is composed of 12 catalytic subunits that are linked to noncatalytic collagen-like subunits through intersubunit disulfide bonds. G2 AChE is localiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ccfc6f9e4410a4daa8d71d6fa48a857
https://doi.org/10.1016/s0021-9258(20)89471-x
https://doi.org/10.1016/s0021-9258(20)89471-x
Autor:
D M, Cerasoli, E M, Griffiths, B P, Doctor, A, Saxena, J M, Fedorko, N H, Greig, Q S, Yu, Y, Huang, H, Wilgus, C N, Karatzas, I, Koplovitz, D E, Lenz
Publikováno v:
Chemico-biological interactions.
Previous studies in rodents and nonhuman primates have demonstrated that pretreatment with cholinesterases can provide significant protection against behavioral and lethal effects of nerve agent intoxication. Human butyrylcholinesterase (HuBuChE) pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a72eefdfe509b68cfaac59bb0669b330
https://pubmed.ncbi.nlm.nih.gov/16429486
https://pubmed.ncbi.nlm.nih.gov/16429486
Publikováno v:
Chemico-biological interactions.
We investigated whether transcriptional inducers could enhance the expression of acetylcholinesterase (AChE) in cell lines to achieve protection against organophosphate (OP) poisoning. Trichostatin A (TSA), an inhibitor of histone deacetylase that de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0daf5bba5c269d2c4d7961ee75dd1935
https://pubmed.ncbi.nlm.nih.gov/16429504
https://pubmed.ncbi.nlm.nih.gov/16429504
Publikováno v:
Chemico-biological interactions.
Human serum butyrylcholinesterase (Hu BChE) has been demonstrated to be a highly effective detoxifying enzyme for counteracting the acute toxicity of organophosphorus (OP) nerve agents. In order to initiate an investigational new drug (IND) applicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c4f37bd23744f9b0abacbcbc4502ae9
https://pubmed.ncbi.nlm.nih.gov/16429577
https://pubmed.ncbi.nlm.nih.gov/16429577
Publikováno v:
Chemico-Biological Interactions. :409-410
We investigated whether transcriptional inducers could enhance the expression of acetylcholinesterase (AChE) in cell lines to achieve protection against organophosphate (OP) poisoning. Trichostatin A (TSA), an inhibitor of histone deacetylase that de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c59884012a75166165a2cc27e005269
https://doi.org/10.1016/j.cbi.2005.10.079
https://doi.org/10.1016/j.cbi.2005.10.079
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 10(4)
S-Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad of biological and biochemical events. Although it has been claimed that AdoMet itself has therapeutic benefits, it remains to be established whether it can be tak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::025a45777329d7187ebe526a2bca5ee4
https://pubmed.ncbi.nlm.nih.gov/8647346
https://pubmed.ncbi.nlm.nih.gov/8647346
Publikováno v:
Molecular pharmacology. 44(6)
The monoclonal antibody AE-2, raised against the human erythrocyte acetylcholinesterase (AChE) dimer (acetylcholine acetylhydrolase, EC 3.1.1.7), binds to other mammalian AChEs, including the tetramer that occurs in fetal bovine serum (FBS). AE-2 par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c480640917e30224c155d4d572ebca0e
https://pubmed.ncbi.nlm.nih.gov/8264551
https://pubmed.ncbi.nlm.nih.gov/8264551
Publikováno v:
Protein science : a publication of the Protein Society. 2(3)
Based on the recently determined X-ray structures of Torpedo californica acetylcholinesterase and Geotrichum candidum lipase and on their three-dimensional superposition, an improved alignment of a collection of 32 related amino acid sequences of oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0f3937ca813d20e215a1c160c99460a
https://pubmed.ncbi.nlm.nih.gov/8453375
https://pubmed.ncbi.nlm.nih.gov/8453375