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Akademický článek

High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)

Abstract Influenza and other respiratory viruses present a significant threat to public health, national security, and the world economy, and can lead to the emergence of global pandemics such as from COVID-19. A barrier to the development of effecti

Externí odkaz: https://doaj.org/article/e5eb566b6b03413b9f2ac96acfa86144

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A high-throughput microfluidic bilayer co-culture platform to study endothelial-pericyte interactions

Autor: Robert Gaibler, Miles Rogers, Corin Williams, Rivka Strelnikov, Hesham Azizgolshani, Nerses J. Haroutunian, Ashley L. Gard, Lindsay Tomlinson, Matthew P. Lech, Philip M. Keegan, Brett C. Isenberg, B P Cain, Nicole E. Raustad, Jeffrey T. Borenstein, Joseph L. Charest, T J Mulhern

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports

Microphysiological organ-on-chip models offer the potential to improve the prediction of drug safety and efficacy through recapitulation of human physiological responses. The importance of including multiple cell types within tissue models has been w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e7982bcf40fc8a1d3759f70ee9785f
https://doaj.org/article/8cf0ffca17424706a726f4770e2e96bd

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High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows

Publikováno v: Lab on a chip. 21(8)

Drug development suffers from a lack of predictive and human-relevant in vitro models. Organ-on-chip (OOC) technology provides advanced culture capabilities to generate physiologically appropriate, human-based tissue in vitro, therefore providing a r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0a71b425453dd13b6fdb6d5d297338
https://pubmed.ncbi.nlm.nih.gov/33881130

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High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)

Influenza and other respiratory viruses present a significant threat to public health, national security, and the world economy, and can lead to the emergence of global pandemics such as from COVID-19. A barrier to the development of effective therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07499b78078ff405772befd238e1a40d
https://pubmed.ncbi.nlm.nih.gov/34294757

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Correction: A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions

Autor: Nerses J. Haroutunian, Kelly Tan, Vishal Tandon, Else M. Vedula, Brett C. Isenberg, Philip M. Keegan, Louis B. Kratchman, Miles Rogers, Jonathan R. Coppeta, Shyam Sundhar Bale, Hesham Azizgolshani, Veronica Newlin, Stephanie Golmon, B P Cain, Mingjian Lu, Ernest S. Kim, Joseph L. Charest, James R. Gosset, Abigail J Patterson

Publikováno v: Lab on a chip. 20(19)

Correction for ‘A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions’ by Kelly Tan et al., Lab Chip, 2019, 19, 1556–1566, DOI: 10.1039/C8LC01262H.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d68894f22f5b4480435d1dcb4b53b14
https://pubmed.ncbi.nlm.nih.gov/30855604

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High-Throughput Human Primary Cell-Based Airway Model for Evaluating Influenza, Coronavirus, or other Respiratory Viruses in vitro

Autor: Jeffrey T. Borenstein, Jenna L. Balestrini, R J Luu, Brett C. Isenberg, Ashley L. Gard, Jonathan R. Coppeta, B P Cain, Hesham Azizgolshani, Robert W. Finberg, Pengpeng Liu, R. F. Fezzie, R. Maloney, Jennifer P. Wang, C. R. Miller

Influenza and other respiratory viruses represent a significant threat to public health, national security, and the world economy, and can lead to the emergence of global pandemics such as the current COVID-19 crisis. One of the greatest barriers to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f357df44723fc24270c1014fb624df8
https://doi.org/10.1101/2020.05.23.112797

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Gelatin methacrylate-alginate hydrogel with tunable viscoelastic properties

Autor: Pranav Soman, Yong X. Chen, B P Cain

Publikováno v: AIMS Materials Science, Vol 4, Iss 2, Pp 363-369 (2017)

Although native extracellular matrix (ECM) is viscoelastic, synthetic biomaterials used in biomedical engineering to mimic ECM typically exhibit a purely elastic response when an external strain is applied. In an effort to truly understand how living

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f57ebee90081969a5af4783845c8e6
https://doi.org/10.3934/matersci.2017.2.363

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A thermoplastic microfluidic microphysiological system to recapitulate hepatic function and multicellular interactions

Autor: Alex Markoski, Hesham Azizgolshani, Shyam Sundhar Bale, Philip M. Keegan, B P Cain, Mingjian Lu, Joseph L. Charest, Jonathan R. Coppeta, James R. Gosset, Andrea Manoppo, Rebecca Thompson, Veronica Newlin, Abbie Spencer, Nerses J. Haroutunian

Publikováno v: Biotechnology and bioengineering. 116(12)

Hepatic in vitro platforms ranging from multi-well cultures to bioreactors and microscale systems have been developed as tools to recapitulate cellular function and responses to aid in drug screening and disease model development. Recent developments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba45ddae8cd9e938d3fbab4362af0ab
https://pubmed.ncbi.nlm.nih.gov/30963546

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