Zobrazeno 1 - 10
of 33
pro vyhledávání: '"B. P. C. Koeleman"'
Autor:
N. Dirkx, Wout J. Weuring, E. De Vriendt, N. Smal, J. van de Vondervoort, Ruben van ’t Slot, M. Koetsier, N. Zonnekein, Tim De Pooter, S. Weckhuysen, B. P. C. Koeleman
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Prime editing (PE) is the most recent gene editing technology able to introduce targeted alterations to the genome, including single base pair changes, small insertions, and deletions. Several improvements to the PE machinery have
Externí odkaz:
https://doaj.org/article/1f458b182d604f85b62a269b125c9ff9
Autor:
Chantal Mathieu, A. R. Van Der Slik, Nicky J C Woittiez, Tanja Nikolic, Bart O. Roep, Antoinette M. Joosten, Sandra Laban, Conny Gysemans, Jaap-Jan Zwaginga, B. P. C. Koeleman
Publikováno v:
Genes and Immunity, 18(3), 176-183
Tolerogenic dendritic cells (tolDCs) are assessed as immunomodulatory adjuvants to regulate autoimmunity. The underlying gene expression endorsing their regulatory features remains ill-defined. Using deep mRNA sequencing, we compared transcriptomes o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb55deb6b60a42dc58c00deebda537e
https://hdl.handle.net/1887/114851
https://hdl.handle.net/1887/114851
Autor:
Arnaud Zaldumbide, V M de Jong, B. P. C. Koeleman, A. R. Van Der Slik, Bart O. Roep, R. van 't Slot, Sandra Laban
Publikováno v:
Genes and Immunity, 17(6), 342-348
Autoreactive CD8(+) T cells recognizing autoantigens expressed by pancreatic islets lead to the destruction of insulin-producing beta cells in type 1 diabetes (T1D), but these T cells also occur in healthy subjects. We tested the hypothesis that unco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d058e058b7f4093954b13d85e3063a1
http://hdl.handle.net/1887/112082
http://hdl.handle.net/1887/112082
Autor:
Sandra Laban, A. R. Van Der Slik, B. P. C. Koeleman, Bart O. Roep, V M de Jong, Arnaud Zaldumbide
Publikováno v:
Genes and Immunity, 17(1), 75-78
Genes and Immunity, 17(1), 75-78. NATURE PUBLISHING GROUP
Genes and Immunity, 17(1), 75-78. NATURE PUBLISHING GROUP
Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) is a protein receptor that downregulates the immune system. CTLA4 gene variants associate with various autoimmune diseases, including type 1 diabetes. Fine mapping of the genetic risk has shown that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b0190fe9ab394547216bf7b5592207
https://hdl.handle.net/1887/99393
https://hdl.handle.net/1887/99393
Autor:
P. H. C. Kremer, G Je Rinkel, Frank P. Diekstra, B. P. C. Koeleman, L.H. van den Berg, Catharina J.M. Klijn, Jan H. Veldink
Publikováno v:
Journal of Neurology, Neurosurgery, and Psychiatry, 87, 693-6
Journal of Neurology, Neurosurgery, and Psychiatry, 87, 7, pp. 693-6
Journal of Neurology, Neurosurgery, and Psychiatry, 87, 7, pp. 693-6
Item does not contain fulltext BACKGROUND: Case-control studies have reported multiple genetic loci to be associated with sporadic brain arteriovenous malformations (AVMs) but most of these have not been replicated in independent populations. The aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a2530498b74de91b2598109ed8af8b
http://hdl.handle.net/2066/168166
http://hdl.handle.net/2066/168166
Autor:
Nina A. Daha, Jeanine J. Houwing-Duistermaat, Tore Saxne, B. P. C. Koeleman, T. W. J. Huizinga, Anthony G. Wilson, Elisabet Lindqvist, A. Zhernakoza, A. Krabben, Rachel Knevel, A.H.M. van der Helm-van Mil, M. P. M. van der Linden, M. D. Posthumus, L. van Toorn, René E. M. Toes, Elisabeth Brouwer, D. P. C. de Rooy, G. Stoeken, Roula Tsonaka
Publikováno v:
Annals of the Rheumatic Diseases; Vol 71
Annals of the Rheumatic Diseases, 71(10), 1651-1657
Annals of the Rheumatic Diseases, 71(10), 1651-1657. BMJ PUBLISHING GROUP
Annals of the Rheumatic Diseases, 71(10), 1651-1657
Annals of the Rheumatic Diseases, 71(10), 1651-1657. BMJ PUBLISHING GROUP
Background Interleukin (IL)-15 levels are increased in serum, synovium and bone marrow of patients with rheumatoid arthritis (RA). IL-15 influences both the innate and the adaptive immune response; its major role is activation and proliferation of T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d586741e3896200a9aa24279c270ee7e
https://doi.org/10.1136/annrheumdis-2011-200724
https://doi.org/10.1136/annrheumdis-2011-200724
Autor:
C. Pfleger, Behrooz Z. Alizadeh, Henrik B. Mortensen, Bart O. Roep, A. V. Kharagjitsingh, Nanette C. Schloot, Lars Hansen, Karsten Buschard, A. Kaas, B. P. C. Koeleman
Publikováno v:
Diabetic Medicine. 29:734-741
Diabet. Med. 29, 734741 (2012) Abstract Aims The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFN?) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41e40b395dadb00fd10dedbf0d3da13a
https://doi.org/10.1111/j.1464-5491.2011.03544.x
https://doi.org/10.1111/j.1464-5491.2011.03544.x
Autor:
Elena Urcelay, Alfonso Martínez, E G de la Concha, Bart O. Roep, H. de la Calle, M. A. Figueredo, Jose Luis Santiago, Miguel Fernández-Arquero, B. P. C. Koeleman, Behrooz Z. Alizadeh, L. Espino
Publikováno v:
Diabetologia. SPRINGER
Diabetologia, 51(9), 1653-1658. SPRINGER
Diabetologia, 51(9), 1653-1658. SPRINGER
Aims/hypothesis In the past few years, several genes outside the MHC region have been described as new susceptibility genetic factors to type 1 diabetes. An association between CAPSL-rs1445898 and type 1 diabetes was reported in a large white populat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b3fb3e504121aea2d3bef59f6d0a50
https://doi.org/10.1007/s00125-008-1070-4
https://doi.org/10.1007/s00125-008-1070-4
Autor:
Adina Zeidler, Ingrid Kockum, Glenys Thomson, Henry A. Erlich, Hiroshi Ikegami, Kjersti S. Rønningen, Antonio Petrone, Francesco Cucca, CB Sanjeevi, F. Leyva-Cobian, A. P. Lambert, Kathleen M Gillespie, A. Santiago-Cortes, T. Frazer de Llado, J. S. Dorman, J. Najman, Güher Saruhan-Direskeneli, Flemming Pociot, Mark N. Grote, T. L. Bugawan, Polly J. Bingley, Chaim Brautbar, B. P. C. Koeleman, E. Dametto, M. E. Fasano, Raffaella Buzzetti, Jin-Xiong She, Erik Thorsby, Soh Ha Chan, Jorma Ilonen, B. R. Hawkins, Robert Hermann, C. Gorodezky, Sophie Caillat-Zucman, Ana M. Valdes, F.A. Uyar, Bernhard O. Boehm, Leslie J. Raffel, M. Berrino, Wojciech Młynarski, Janelle A. Noble, Hülya Günöz, Jerome I. Rotter, C. Alaez, Jørn Nerup, Åke Lernmark, Luis Castaño, Dag E. Undlien, Bart O. Roep, Ann R. Steenkiste, Alberto Pugliese, Shoshana Israel
Publikováno v:
Tissue Antigens. 70:110-127
The direct involvement of the human leukocyte antigen class II DR-DQ genes in type 1 diabetes (T1D) is well established, and these genes display a complex hierarchy of risk effects at the genotype and haplotype levels. We investigated, using data fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c7d55be189c3cc1768836813d40830
https://doi.org/10.1111/j.1399-0039.2007.00867.x
https://doi.org/10.1111/j.1399-0039.2007.00867.x
Autor:
Bart O. Roep, P. Eerligh, A. R. Van Der Slik, B. P. C. Koeleman, I. Van Den Eng, Marius J. Giphart, Ilias I.N. Doxiadis
Publikováno v:
Tissue Antigens. 69:348-353
The extended major histocompatibility complex (xMHC) has been studied intensively with regard to type 1 diabetes (T1D) predisposition. So far, little attention has been given to the subregion centromeric of MHC class II. We selected five single nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891350bb6a0beb8d3c06aa196ae6ddf1
https://doi.org/10.1111/j.1399-0039.2007.00820.x
https://doi.org/10.1111/j.1399-0039.2007.00820.x