Zobrazeno 1 - 10
of 232
pro vyhledávání: '"B. Oosterhuis"'
Autor:
Monika Malm-Erjefalt, Hans Helleberg, Milan Zdravkovic, Inga Bjørnsdottir, Uffe Larsen, B. Oosterhuis, Jan Vanggaard, Jan Jaap van Lier, Annette K Olsen
Publikováno v:
Drug Metabolism and Disposition. 38:1944-1953
Liraglutide is a novel once-daily human glucagon-like peptide (GLP)-1 analog in clinical use for the treatment of type 2 diabetes. To study metabolism and excretion of [(3)H]liraglutide, a single subcutaneous dose of 0.75 mg/14.2 MBq was given to hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44609526e019a035a12b19af26e1e7cc
https://doi.org/10.1124/dmd.110.034066
https://doi.org/10.1124/dmd.110.034066
Autor:
Philipp G. Sand, B Oosterhuis, Goeran Hajak, Sanja Locher, KV Vukman, Andrea Dreiseitel, Peter Schreier, Anett Oehme
Publikováno v:
British Journal of Pharmacology. 158:1942-1950
Background and purpose: Dietary anthocyanins hold great promise in the prevention of chronic disease but factors affecting their bioavailability remain poorly defined. Specifically, the role played by transport mechanisms at the intestinal and blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a806da9178da374ef9e77583552e250
https://doi.org/10.1111/j.1476-5381.2009.00495.x
https://doi.org/10.1111/j.1476-5381.2009.00495.x
Autor:
Paul D. Crowe, Robert Farber, R. Colin Garner, Christopher F. O'Brien, Jianyun Wen, B. Oosterhuis, Ajay Madan, Zhihong O’Brien, Graham Lappin, Haig Bozigian, Graham Beaton
Publikováno v:
British Journal of Clinical Pharmacology. 67:288-298
AIMS: To evaluate the pharmacokinetics (PK) of five H1 receptor antagonists in human volunteers after a single oral and intravenous (i.v.) microdose (0.1 mg). METHODS: Five H1 receptor antagonists, namely NBI-1, NBI-2, NBI-3, NBI-4 and diphenhydramin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f8ab0218f680488b5946d4dbfecb71
https://doi.org/10.1111/j.1365-2125.2008.03351.x
https://doi.org/10.1111/j.1365-2125.2008.03351.x
Autor:
Roeline Jochemsen, Ajai Chaudhary, Malcolm Rowland, B. Oosterhuis, Willem Jan Drijfhout, Graham Lappin, Wilhelm Kuhnz, R. Colin Garner, Johannes Kneer
Publikováno v:
Clinical Pharmacology & Therapeutics. 80:203-215
Objectives: A volunteer trial was performed to compare the pharmacokinetics of 5 drugs-warfarin, ZK253 (Schering), diazepam, midazolam, and erythromycin-when administered at a microdose or pharmacologic dose. Each compound was chosen to represent a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de2d1d417c676128bca41372576d12c
https://doi.org/10.1016/j.clpt.2006.05.008
https://doi.org/10.1016/j.clpt.2006.05.008
Publikováno v:
Biopharmaceutics & Drug Disposition. 24:159-164
Objectives - To study the effect of age and renal function on the pharmacokinetic profile of a modified release tablet of trimetazidine (TMZ MR 35 mg) administered twice daily.Methods- Study 1: Twelve healthy elderly subjects (CL(creat) 72+/-8 ml/min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c29619b0e28a9d35101145ae6ee47a
https://doi.org/10.1002/bdd.350
https://doi.org/10.1002/bdd.350
Autor:
Ch. B. Lugt, P. A. M. Peeters, Polrat Wilairatana, Sornchai Looareesuwan, Frans A. E. Sollie, B. M. Schilizzi, James O. Peggins, B. Oosterhuis, Srivicha Krudsood
Publikováno v:
British Journal of Clinical Pharmacology. 53:492-500
Aims The antimalarial efficacy/pharmacodynamics and pharmacokinetics of intramuscular (i.m.) artemotil in Thai patients with acute uncomplicated falciparum malaria were studied to determine effective dose regimens and to compare these with the standa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58812b795f8e04ee845527130e449e87
https://doi.org/10.1046/j.1365-2125.2002.01590.x
https://doi.org/10.1046/j.1365-2125.2002.01590.x
Autor:
Jan P. G. Brakenhoff, Lou F. M. H. de Leij, Mireille G. F. Gerrits, Rokus A. de Zeeuw, Johan Wemer, W.J Tamminga, Jan H.G. Jonkman, B. Oosterhuis
Publikováno v:
European Journal of Clinical Pharmacology. 57:143-146
A method for simultaneous phenotyping and genotyping for CYP2D6 and CYP2C19 was tested. Six healthy volunteers were selected (three extensive and three poor metabolisers for CYP2D6). CYP2D6 was probed with dextromethorphan and metoprolol and CYP2C19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51f8ed1f41e693ccdb41d72cdafc17b
https://doi.org/10.1007/s002280100273
https://doi.org/10.1007/s002280100273
Trends in microdosing and other exploratory human pharmacokinetic studies for early drug development
Autor:
B. Oosterhuis
Publikováno v:
Bioanalysis. 2:377-379
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5283667399ca18a40728d4b02ff79c
https://doi.org/10.4155/bio.10.11
https://doi.org/10.4155/bio.10.11
Autor:
Frans A. E. Sollie, B. Oosterhuis, Chung‐An P. F. Su, Jan H. G. Jonkman, Jan J. van Lier, Maarten G. C. Hendriks, Joachim Stangier
Publikováno v:
The Journal of Clinical Pharmacology. 40:1331-1337
The effects of multiple-dose telmisartan on the steady-state pharmacodynamics and pharmacokinetics of warfarin were assessed in 12 healthy young males in an open-label, single-period study conducted over 30 days. Subjects received loading doses of or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a82d46e0c009d5ad7e13a671ced964a5
https://doi.org/10.1177/009127000004001204
https://doi.org/10.1177/009127000004001204
The Effect of Telmisartan on the Steady‐State Pharmacokinetics of Digoxin in Healthy Male Volunteers
Autor:
Jan J. van Lier, B. Oosterhuis, Joachim Stangier, Frans A. E. Sollie, Chung‐An P. F. Su, Jan H. G. Jonkman, Maarten G. C. Hendriks
Publikováno v:
The Journal of Clinical Pharmacology. 40:1373-1379
A multiple-dose, open-label, two-period, crossover randomized study was conducted in 12 healthy male volunteers to investigate the effect of multiple-dose telmisartan on the steady-state pharmacokinetics of digoxin. On day 1 of a 7-day medication per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f4d6f7b4d2c85efb9c0bcbcb286890b
https://doi.org/10.1177/009127000004001209
https://doi.org/10.1177/009127000004001209