Zobrazeno 1 - 10
of 32
pro vyhledávání: '"B. Ochoa-Lizarralde"'
Autor:
T. Kaminishi, Retina Çapuni, C. Gualerzi, Sean R. Connell, B. Ochoa-Lizarralde, Paola Fucini, A. Schedlbauer, X. Han, Pohl Milón, Attilio Fabbretti
The ribosome is a major target for antibiotics owing to its essential cellular role in protein synthesis. Structural analysis of ribosome-antibiotic complexes provides insight into the molecular basis for their inhibitory action and highlights possib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bced00caafe6c9d98ccb66ffe8927cb0
https://doi.org/10.1101/2021.11.29.470217
https://doi.org/10.1101/2021.11.29.470217
Autor:
Andreas Schedlbauer, Sean R. Connell, Elisa de Astigarraga, Jorge P. López-Alonso, T. Kaminishi, Neha Dhimole, B. Ochoa-Lizarralde, Paola Fucini, Tammo Diercks, Retina Çapuni, José Luis Lavín, David Gil-Carton, Idoia Iturrioz
Publikováno v:
Science Advances
This study highlights the molecular mechanisms of four assembly factors in folding the ribosomal central decoding region.
While a structural description of the molecular mechanisms guiding ribosome assembly in eukaryotic systems is emerging, bac
While a structural description of the molecular mechanisms guiding ribosome assembly in eukaryotic systems is emerging, bac
Backbone and sidechain NMR assignments for the ribosome maturation factor RimP from Escherichia coli
Autor:
Xu Han, Idoia Iturrioz, B. Ochoa-Lizarralde, Paola Fucini, Tammo Diercks, Andreas Schedlbauer, Elisa de Astigarraga, Retina Çapuni, Sean R. Connell
Publikováno v:
Biomolecular NMR assignments. 14(2)
Ribosome biogenesis is an energetically expensive and complex cellular process that involves the coordinated folding of the ribosomal RNA and dozens of ribosomal proteins. It proceeds along multiple parallel pathways and is guided by trans-acting fac
Autor:
B. Ochoa-Lizarralde, Paola Fucini, Benn, Yang F, Liu Q, Retina Çapuni, Connell, Zhang M, Andreas Schedlbauer, T. Kaminishi, de Astigarraga E, Tan X
Antibiotic resistance is a growing threat to human health requiring the discovery or development of new anti-infectives. As such, KBP-7072 is a novel tetracycline derivative that exhibits broad-spectrum activity against Gram-positive and -negative ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97589be1713fbfcc925033350fc84769
Autor:
T. Kaminishi, Shigeyuki Yokoyama, Chie Takemoto, Andreas Schedlbauer, B. Ochoa-Lizarralde, Paola Fucini, Raffaella Garofalo, Letizia Brandi, Sean R. Connell, Attilio Fabbretti, Anna Maria Giuliodori, Claudio O. Gualerzi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
In prokaryotic systems, the initiation phase of protein synthesis is governed by the presence of initiation factors that guide the transition of the small ribosomal subunit (30S) from an unlocked preinitiation complex (30S preIC) to a locked initiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18049a01eebf84b564057098fcf2c74
https://hdl.handle.net/11858/00-001M-0000-002A-5C08-811858/00-001M-0000-002A-5C07-A11858/00-001M-0000-002A-5C00-7
https://hdl.handle.net/11858/00-001M-0000-002A-5C08-811858/00-001M-0000-002A-5C07-A11858/00-001M-0000-002A-5C00-7
Autor:
Letizia Brandi, Sean R. Connell, Pohl Milón, Attilio Fabbretti, B. Ochoa-Lizarralde, Paola Fucini, T. Kaminishi, Cheng-Guang He, Andreas Schedlbauer, Claudio O. Gualerzi
Publikováno v:
Europe PubMed Central
'Nucleic Acids Research ', vol: 43, pages: 10015-10025 (2015)
Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Académico-UPC
UPC-Institucional
Universidad Peruana de Ciencias Aplicadas
instacron:UPC
Nucleic Acids Research
'Nucleic Acids Research ', vol: 43, pages: 10015-10025 (2015)
Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Académico-UPC
UPC-Institucional
Universidad Peruana de Ciencias Aplicadas
instacron:UPC
Nucleic Acids Research
Hygromycin A (HygA) binds to the large ribosomal subunit and inhibits its peptidyl transferase (PT) activity. The presented structural and biochemical data indicate that HygA does not interfere with the initial binding of aminoacyl-tRNA to the A site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b03d5a73bd032b14242ba06b2689d01
Akademický článek
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Autor:
Neha Dhimole, Shu Zhou, B. Ochoa-Lizarralde, Paola Fucini, Sean R. Connell, T. Kaminishi, Jorge P. López-Alonso, Andreas Schedlbauer
Although both tetracycline and tigecycline inhibit protein synthesis by sterically hindering the binding of tRNA to the ribosomal A site, tigecycline shows increased efficacy in both in vitro and in vivo activity assays and escapes the most common re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b225474a298213f30245e66a9d1030bb
https://europepmc.org/articles/PMC4394779/
https://europepmc.org/articles/PMC4394779/
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
B. Ochoa-Lizarralde, L. Malinina, R.E. Brown, V. R. Samygina, A. Cabo-Bilbao, D.J. Patel, Alexander Popov
Publikováno v:
Acta Crystallographica Section A Foundations of Crystallography. 67:C289-C289