Zobrazeno 1 - 10
of 21
pro vyhledávání: '"B. N. Rogers"'
Autor:
N S Redhu, M Rowe, D Lee, D Jain, A Sang, D Granata, B Harrison, D Cui, M Bursavich, A S Ray, B Lippa, B N Rogers, J Wong
Publikováno v:
Journal of Crohn's and Colitis. 17:i265-i266
Background Integrin α4β7 regulates the recruitment of T cells to intestinal mucosa through its interaction with mucosal addressin cell adhesion molecule (MAdCAM)-1. Disruption of this interaction has been clinically validated for the treatment of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d2f00c6e4a545ee14890357b54c8930
https://doi.org/10.1093/ecco-jcc/jjac190.0232
https://doi.org/10.1093/ecco-jcc/jjac190.0232
Autor:
T P Stern, P W Krzeski, D Cui, N. Vande Casteele, P G Traber, Jennifer Jones, P G Linde, C L Soo, H Nguyen, G Bain, M M Mangada, A S Ray, B N Rogers, M M Reardon, D Lee, L H Vrishabhendra
Publikováno v:
Journal of Crohn's and Colitis. 15:S333-S335
Background MORF-057 is an orally administered small molecule designed to inhibit the α 4β 7 receptor, addressing an unmet medical need in inflammatory bowel disease (IBD) patients, and avoiding the need for periodic therapeutic infusions and the ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd90790d0257a60bdbdcfb1773d64c69
https://doi.org/10.1093/ecco-jcc/jjab076.430
https://doi.org/10.1093/ecco-jcc/jjab076.430
Autor:
J Wong, D Lee, M Mangada, V Yadav, D Troast, C Zhong, K Hahn, W Wang, X Ge, L Sun, S Jiang, B Wang, J Zhang, L Yan, H Nguyen, D Cui, M G Bursavich, B Lippa, B N Rogers, A S Ray
Publikováno v:
Journal of Crohn's and Colitis. 16:i098-i099
Background Disruption of immune cell trafficking via integrins is a proven and effective mechanism for treating inflammatory bowel disease. When α4β7 integrin is inhibited through pharmacological intervention, immune cells destined for the gut tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80572a77998d3aad4f5af50666deaad1
https://doi.org/10.1093/ecco-jcc/jjab232.089
https://doi.org/10.1093/ecco-jcc/jjab232.089
Autor:
I Smukste, J Jones, C Zhong, M M Mangada, B N Rogers, D Cui, G Bain, J E Wong, D Troast, M G Bursavich, A S Ray, D Lee, B Lippa
Publikováno v:
Journal of Crohn's and Colitis. 15:S149-S150
Background MORF-057 is a potent and selective small molecule inhibitor of the α 4β 7 integrin. Using a receptor occupancy (RO) assay under physiologically relevant conditions, MORF-057 achieves 90% α 4β 7 RO at approximately 10 nM in human whole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58e2e56771e7841902535c45727fb40f
https://doi.org/10.1093/ecco-jcc/jjab076.166
https://doi.org/10.1093/ecco-jcc/jjab076.166
Autor:
A Camblin, T Moy, J E Wong, M Krumpoch, L Wang, M McShea, A Sullivan, B Lippa, A Lugovsky, C Zhong, K Hahn, L Cappellucci, B N Rogers, D Troast, R Cohen, N Blanco, D Lee, M G Bursavich, S Mostafavi, F Y Lin, D Cui
Publikováno v:
Journal of Crohn's and Colitis. 14:S102-S103
Background Integrins play a key role in facilitating immune cell trafficking throughout the body and represent an important receptor family for therapeutic intervention. In particular, the α4β7 integrin is a clinically validated target for the trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8899ddc1062c59d9c4031ab69eae26c1
https://doi.org/10.1093/ecco-jcc/jjz203.103
https://doi.org/10.1093/ecco-jcc/jjz203.103
Autor:
J. L. Terry, B. Bai, Klaus Hallatschek, D. Kopon, W. M. Nevins, C. S. Pitcher, C. J. Boswell, Brian LaBombard, B. N. Rogers, D.P. Stotler, R. J. Maqueda, Martin Greenwald, S. J. Zweben, Xueqiao Xu
Publikováno v:
Physics of Plasmas. 10:1739-1747
The intermittent turbulent transport in the scrape-off-layer (SOL) of Alcator C-Mod [I.H. Hutchinson, R. Boivin, P.T. Bonoli et al., Nucl. Fusion 41, 1391 (2001)] is studied experimentally by imaging with a very high density of spatial measurements.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0511b5b231edfcff5f0c879c0a17498f
https://doi.org/10.1063/1.1564090
https://doi.org/10.1063/1.1564090
Publikováno v:
Geophysical Research Letters. 27:3157-3160
Two dimensional simulations of collisionless magnetic reconnection produce strong gradients in the current and plasma profiles near the magnetic X-line and along the separatrix during the nonlinear phase. Here we present 3D two-fluid MHD simulations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::583b528a938cdc30afc9e52318335193
https://doi.org/10.1029/2000gl000038
https://doi.org/10.1029/2000gl000038
Publikováno v:
Nuclear Fusion. 40:873-878
Report on the IAEA Technical Committee Meeting held at Kloster Seeon, Germany, 21-23 June 1999
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f9403c197c6af35dbe5390f607fb920
https://doi.org/10.1088/0029-5515/40/4/411
https://doi.org/10.1088/0029-5515/40/4/411
Publikováno v:
Physical Review Letters. 84:99-102
Based on three-dimensional simulations of the Braginskii equations we show that for typical plasma-edge parameters the saturation of electromagnetic toroidal eta(i) mode turbulence is controlled by the self-generation and subsequent annihilation of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53c4d66f8c006db833c0b0e3e292f282
https://doi.org/10.1103/physrevlett.84.99
https://doi.org/10.1103/physrevlett.84.99
Publikováno v:
Geophysical Research Letters. 26:2163-2166
Hybrid simulations with electron inertia, along with analytic scaling arguments, are presented which demon- strate that magnetic reconnection remains Alfv6nic in a col- lisionless system even as the macroscopic scale length of the system becomes very
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c7aca19f563ed0f476f0156975f62a6
https://doi.org/10.1029/1999gl900481
https://doi.org/10.1029/1999gl900481