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Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients

Autor: Maureen Dillon, L. Garrett, Scott Chasan-Taber, R. Zabaneh, Wadi N. Suki, Steven K. Burke, D. Fischer, B. N. Ling, Jon A. Reed, J. L. Cangiano, Andrew T. Blair

Publikováno v: Kidney International. 72(9):1130-1137

Elevated serum phosphorus and calcium are associated with arterial calcification and mortality in dialysis patients. Unlike calcium-based binders, sevelamer attenuates arterial calcification but it is unknown whether sevelamer affects mortality or mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e16e57ddcfe9e3526205e43446b5ea

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Regulation of mesangial chloride channels by insulin and glucose: role in diabetic nephropathy

Autor: B N, Ling

Publikováno v: Clinical and experimental pharmacologyphysiology. 23(1)

1. In response to vasoactive peptides (e.g. angiotensin II (AngII), vasopressin, endothelin-1, platelet-activating factor), glomerular mesangial cell contraction is mediated through activation of a Ca2+-dependent Cl- conductance that, in turn, promot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5f65e381a1ac2713b7a5790ba96d6a2
https://pubmed.ncbi.nlm.nih.gov/8713502

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Ca(2+)-dependent and Ca(2+)-permeable ion channels in aortic endothelial cells

Autor: W. C. O'Neill, B. N. Ling

Publikováno v: The American journal of physiology. 263(6 Pt 2)

We investigated whether osmotic stress would activate specific ion channels in bovine aortic endothelial cells (BAECs). In isotonic medium (290 mosmol/kgH2O), cell-attached patch recordings contained both 165-pS K+ channels activated by depolarizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2745bb0a62694a4d827dad39c54561f
https://pubmed.ncbi.nlm.nih.gov/1282784

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Ion Channels in Epithelial Tissue: Single-Channel Properties

Autor: B. N. Ling, D. C. Eaton, Y. Marunaka

Publikováno v: Membrane Transport in Biology ISBN: 9783642769856

A major function of a cell membrane is to form a barrier between the internal environment of the cell and the external world. However, a complete barrier to the outside world is unacceptable since to survive cells require some ability to communicate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fa67fd2709c575720766a861309c481
https://doi.org/10.1007/978-3-642-76983-2_3

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Effects of luminal Na+ on single Na+ channels in A6 cells, a regulatory role for protein kinase C

Autor: B. N. Ling, D. C. Eaton

Publikováno v: American Journal of Physiology-Renal Physiology. 256:F1094-F1103

Na+ "self-inhibition" in tight epithelia describes the reduction in apical Na+ permeability observed with increasing luminal Na+ concentration. Patch clamp was used to examine regulation of self-inhibition at the level of single Na+ channels. After c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fadfbbadb93384e69ee6755815bfdc
https://doi.org/10.1152/ajprenal.1989.256.6.f1094

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Extracellular glucose reduces the responsiveness of mesangial cell ion channels to angiotensin II

Autor: E. E. Seal, Douglas C. Eaton, He-Ping Ma, L. M. Gomez, B. N. Ling

Publikováno v: Europe PubMed Central

Abnormal cellular ion homeostasis is a well-recognized component of diabetic glomerular disease. In cultured rat glomerular mesangial cells, we have previously shown that insulin regulates Ca(2+)-dependent activation of 4-pS Cl- channels and 27-pS no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac5f686a917402990075fae6be51789
http://europepmc.org/abstract/med/7573488

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