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Autor:
Marjorie S. Solomon, Stacia M. Rink, B. Mitra Tadayoni-Rebek, Lisa A. Paige, Robert G. Croy, Kevin J. Yarema, John M. Essigmann
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 93(26)
It is a goal of cancer chemotherapy to achieve the selective killing of tumor cells while minimizing toxicity to normal tissues. We describe the design of selective toxins forming DNA adducts that attract the estrogen receptor (ER), a transcription f