Zobrazeno 1 - 10
of 240
pro vyhledávání: '"B. Michael Ghadimi"'
Autor:
Sushant Patkar, Kerstin Heselmeyer-Haddad, Noam Auslander, Daniela Hirsch, Jordi Camps, Daniel Bronder, Markus Brown, Wei-Dong Chen, Rachel Lokanga, Darawalee Wangsa, Danny Wangsa, Yue Hu, Annette Lischka, Rüdiger Braun, Georg Emons, B. Michael Ghadimi, Jochen Gaedcke, Marian Grade, Cristina Montagna, Yuri Lazebnik, Michael J. Difilippantonio, Jens K. Habermann, Gert Auer, Eytan Ruppin, Thomas Ried
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-16 (2021)
Abstract Background Many carcinomas have recurrent chromosomal aneuploidies specific to the tissue of tumor origin. The reason for this specificity is not completely understood. Methods In this study, we looked at the frequency of chromosomal arm gai
Externí odkaz:
https://doaj.org/article/5ccb78cdd26b4762976deb16d27ec9ec
Targeting STAT3 Signaling Facilitates Responsiveness of Pancreatic Cancer Cells to Chemoradiotherapy
Autor:
Hannah Flebbe, Melanie Spitzner, Philipp Enno Marquet, Jochen Gaedcke, B. Michael Ghadimi, Stefan Rieken, Günter Schneider, Alexander O. Koenig, Marian Grade
Publikováno v:
Cancers, Vol 14, Iss 5, p 1301 (2022)
The debate is ongoing regarding the potential role of preoperative chemoradiotherapy (CRT) for patients with pancreatic ductal adenocarcinoma (PDAC), and whether it should be reserved for borderline resectable or unresectable tumors. However, treatme
Externí odkaz:
https://doaj.org/article/555054ec406f4940a3b12614d0786817
Autor:
Melanie Spitzner, Georg Emons, Karl Burkhard Schütz, Hendrik A. Wolff, Stefan Rieken, B. Michael Ghadimi, Günter Schneider, Marian Grade
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10301 (2021)
The standard treatment of locally advanced esophageal cancer comprises multimodal treatment concepts including preoperative chemoradiotherapy (CRT) followed by radical surgical resection. However, despite intensified treatment approaches, 5-year surv
Externí odkaz:
https://doaj.org/article/bfb7548c700045dc9bfb196f95822085
Autor:
Kristin Koerdel, Melanie Spitzner, Thomas Meyer, Niklas Engels, Florian Krause, Jochen Gaedcke, Lena-Christin Conradi, Martin Haubrock, Tim Beißbarth, Andreas Leha, Steven A. Johnsen, B. Michael Ghadimi, Stefan Rose-John, Marian Grade, Jürgen Wienands
Publikováno v:
Cancers, Vol 13, Iss 3, p 455 (2021)
Resistance of tumor cells to chemoradiotherapy represents a fundamental problem in clinical oncology. The underlying mechanisms are actively debated. Here we show that blocking inflammatory cytokine receptor signaling via STAT3 re-sensitized treatmen
Externí odkaz:
https://doaj.org/article/ff2b049224d34f1daf33128a69b834a5
Autor:
Melanie Spitzner, Reinhard Ebner, Hendrik A. Wolff, B. Michael Ghadimi, Jürgen Wienands, Marian Grade
Publikováno v:
Cancers, Vol 6, Iss 4, Pp 1986-2011 (2014)
Chemoradiotherapy (CRT) represents a standard treatment for many human cancers, frequently combined with radical surgical resection. However, a considerable percentage of primary cancers are at least partially resistant to CRT, which represents a sub
Externí odkaz:
https://doaj.org/article/1768f4b42c8f4054b4e58c3a70886601
Autor:
Hannah Flebbe, Feda H. Hamdan, Vijayalakshmi Kari, Julia Kitz, Jochen Gaedcke, B. Michael Ghadimi, Steven A. Johnsen, Marian Grade
Publikováno v:
Cancers, Vol 11, Iss 8, p 1142 (2019)
Epigenetic alterations play a central role in cancer development and progression. The acetylation of histone 3 at lysine 27 (H3K27ac) specifically marks active genes. While chromatin immunoprecipitation (ChIP) followed by next-generation sequencing (
Externí odkaz:
https://doaj.org/article/220b3fb9a3004f02813fecead7284214
Autor:
Henriette Quack, Luise Erpenbeck, Hendrik A. Wolff, Thilo Sprenger, Cornelia S. Seitz, Michael P. Schön, Steffen Neumann, Kathrin Stanek, B. Michael Ghadimi, Beate Michels, Peter Middel, Inga-Marie Schaefer, Torsten Liersch, Lena-Christin Conradi
Publikováno v:
Case Reports in Oncology, Vol 6, Iss 3, Pp 609-615 (2013)
Leukocytoclastic vasculitis is a multicausal systemic inflammatory disease of the small vessels, histologically characterized by inflammation and deposition of both nuclear debris and fibrin in dermal postcapillary venules. The clinical picture typic
Externí odkaz:
https://doaj.org/article/fa063515e38a4c9ea38338a24576acdc
Autor:
B. Michael Ghadimi, Marian Grade, Carsten Mönkemeyer, Bettina Kulle, Jochen Gaedcke, Bastian Gunawan, Claus Langer, Torsten Liersch, Heinz Becker
Publikováno v:
Cellular Oncology, Vol 28, Iss 5-6, Pp 273-281 (2006)
Background: The prognosis of colorectal cancer patients is to a considerable extent determined by the metastatic potency of the primary tumor. However, despite the fact that liver metastases are the leading cause of death for cancer patients, the mol
Externí odkaz:
https://doaj.org/article/eaa5e8aafe914b08aff41a4a915f1296
Publikováno v:
Cellular Oncology, Vol 28, Iss 3, Pp 71-84 (2006)
Chromosomal aberrations play a dominant role in colorectal carcinogenesis. The application of fluorescence in situ hybridization (FISH) based techniques such as comparative genomic hybridization (CGH) and spectral karyotyping (SKY) revealed that colo
Externí odkaz:
https://doaj.org/article/2dc9165b8f344b8ca8705770f965e57b
Publikováno v:
Cellular Oncology, Vol 27, Iss 1, Pp 3-13 (2005)
Externí odkaz:
https://doaj.org/article/298d2c31685b4097967b0ab27cb418ed