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Prädiktive genetische Untersuchungen: Individualisierung von Diagnostik und Therapie bei Familien mit multipler endokriner Neoplasie Typ II

Autor: A. Pfützner, B. Manfras, S Heerdt, S. Walgenbach, Thomas Forst, T. Kunt, T Hankeln, Peter H. Kann, J. Beyer, Hendrik Lehnert, M. Engelbach

Publikováno v: DMW - Deutsche Medizinische Wochenschrift. 125:37-44

BACKGROUND AND OBJECTIVE When multiple endocrine neoplasia type 2 (MEN2) is suspected, genetic tests are at the centre of screening procedures. It was the aim of this study to compare the diagnostic value of molecular biological investigations with t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5171865f23315b0142a84c8b28ef4db2
https://doi.org/10.1055/s-2007-1023904

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Immunogenetic markers in patients with Graves' disease

Autor: W. Spielmann, E. Schifferdecker, Bernhard O. Böhm, Kühnl P, B. Manfras, Holzberger G, K. Schöffling

Publikováno v: Klinische Wochenschrift. 69:256-260

110 carefully characterized Caucasoid patients with Graves' disease were tested for HLA class I and class II antigens. Compared with Caucasian controls (n = 193), the frequencies of HLA B8, Cw7 and DR3 were significantly increased (pc less than 0.05)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b503dfd5c03a535236304a6064b88077
https://doi.org/10.1007/bf01666851

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Aspartic acid at position 57 of the HLA-DQβ chain is protective against future development of insulin-dependent (Type 1) diabetes mellitus

Autor: K. Schöffling, C. Rosak, Massimo Trucco, B. O. Boehm, B. Manfras

Publikováno v: Klinische Wochenschrift. 69:146-150

Insulin-dependent (Type I) diabetes mellitus is a chronic autoimmune disease. From studies in discordant twins and multiplex families a long prediabetic period has been reported. In a population-based program started in 1983, fifteen individuals at p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66779cc4bc6ceabe8b2e8fe897d6c401
https://doi.org/10.1007/bf01665854

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Opsonization with a trifunctional bispecific (alphaCD3 x alphaEpCAM) antibody results in efficient lysis in vitro and in vivo of EpCAM positive tumor cells by cytotoxic T lymphocytes

Autor: M, Schmitt, A, Schmitt, P, Reinhardt, B, Thess, B, Manfras, H, Lindhofer, H, Riechelmann, M, Wiesneth, S, Gronau

Publikováno v: International journal of oncology. 25(4)

Removab is a trifunctional bispecific antibody which can bridge CD3+ T cells and epithelial cell adhesion molecule positive (EpCAM+) tumor cells, and binds with its Fc fragment to antigen presenting cells. To explore a new approach for the treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ea207587ea4e76f5a817c72dbe2a0029
https://pubmed.ncbi.nlm.nih.gov/15375531

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[Predictive genetic investigations. Individualization of diagnosis and treatment in families with multiple endocrine neoplasia type II]

Autor: M, Engelbach, T, Kunt, P, Kann, B, Manfras, T, Hankeln, T, Forst, A, Pfützner, S, Heerdt, S, Walgenbach, H, Lehnert, J, Beyer

Publikováno v: Deutsche medizinische Wochenschrift (1946). 125(3)

When multiple endocrine neoplasia type 2 (MEN2) is suspected, genetic tests are at the centre of screening procedures. It was the aim of this study to compare the diagnostic value of molecular biological investigations with that of conventional bioch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f379b0b59d9a90b48d0c0ae6bf0a6ea9
https://pubmed.ncbi.nlm.nih.gov/10681996

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Prevalence of HLA-DQ beta chain non-asp alleles in type I (insulin-dependent) diabetics with young and older ages of onset

Autor: Massimo Trucco, K. Schöffling, Werner A. Scherbaum, Klaus-Henning Usadel, P. H. Althoff, Kühnl P, B. O. Boehm, B. Manfras

Publikováno v: Klinische Wochenschrift. 69:687-689

Particular HLA-DQ beta chain alleles were reported as immunogenetic markers of type I diabetes mellitus with young onset of the disease. In a homogeneous German population, we studied HLA-DR specificities and HLA-DQ beta chain alleles in young-onset

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56a6e6078b56768de6d41d4c2d2a5cc
https://doi.org/10.1007/bf01649437

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The HLA-DQβ non-Asp-57 allele: a predictor of future insulin-dependent diabetes mellitus in patients with autoimmune Addison's disease

Autor: Bernhard O. Boehm, C. Rosak, K. Schöffling, Massimo Trucco, S. Seidl, B. Manfras, G. Holzberger, Kühnl P

Publikováno v: Tissue Antigens. 37:130-132

HLA-DR specificities in 72 Addison's (AD) patients and 808 local controls were compared. We confirmed earlier reports that the HLA-DR3 specificity is significantly increased in AD patients. In our study a relative risk of 3.4 chi 2 = 22.5; pc = 0.01)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a305fde3ab0890d1dd5fae58d007bd
https://doi.org/10.1111/j.1399-0039.1991.tb01858.x

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