Zobrazeno 1 - 10
of 554
pro vyhledávání: '"B. MAGUIRE"'
Autor:
Manuel Sigle, Anne-Katrin Rohlfing, Martin Kenny, Sophia Scheuermann, Na Sun, Ulla Graeßner, Verena Haug, Jessica Sudmann, Christian M. Seitz, David Heinzmann, Katja Schenke-Layland, Patricia B. Maguire, Axel Walch, Julia Marzi, Meinrad Paul Gawaz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Spatial transcriptomics of histological sections have revolutionized research in life sciences and enabled unprecedented insights into genetic processes involved in tissue reorganization. However, in contrast to genomic analysis, the actual
Externí odkaz:
https://doaj.org/article/b7ac1719d6d84968857dbc7a99739fe6
Autor:
Moritz Ertelt, Vikram Khipple Mulligan, Jack B Maguire, Sergey Lyskov, Rocco Moretti, Torben Schiffner, Jens Meiler, Clara T Schoeder
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 3, p e1011939 (2024)
Post-translational modifications (PTMs) of proteins play a vital role in their function and stability. These modifications influence protein folding, signaling, protein-protein interactions, enzyme activity, binding affinity, aggregation, degradation
Externí odkaz:
https://doaj.org/article/77e6f2dca787462c97d0b815eb05045b
Autor:
Luisa Weiss, Hayley MacLeod, Shane P. Comer, Sarah Cullivan, Paulina B. Szklanna, Fionnuala Ní Áinle, Barry Kevane, Patricia B. Maguire
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102150- (2023)
Summary: The contents of the platelet releasate (PR) play significant roles in hemostasis, inflammation, and pathologic sequelae. Careful platelet isolation to ensure quiescence and subsequent activation is key to the successful generation of PR. Her
Externí odkaz:
https://doaj.org/article/c2866b26ba16494e90d809ab4b951d49
Autor:
Laura Twomey, Nastassia Navasiolava, Adrien Robin, Marie-Pierre Bareille, Guillemette Gauquelin-Koch, Arnaud Beck, Françoise Larcher, Gerardene Meade-Murphy, Sinead Sheridan, Patricia B. Maguire, Michael Harrison, Bernard Degryse, Niall M. Moyna, Claude Gharib, Marc-Antoine Custaud, Ronan P. Murphy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Ground based research modalities of microgravity have been proposed as innovative methods to investigate the aetiology of chronic age-related conditions such as cardiovascular disease. Dry Immersion (DI), has been effectively used to interro
Externí odkaz:
https://doaj.org/article/b93d0c54ffb846f8add8113daf6fda14
Autor:
Signe E. Cremer, James L. Catalfamo, Robert Goggs, Stefan E. Seemann, Annemarie T. Kristensen, Paulina B. Szklanna, Patricia B. Maguire, Marjory B. Brooks
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 1, Pp 55-68 (2021)
Abstract Background Domestic dogs represent a translational animal model to study naturally occurring human disease. Proteomics has emerged as a promising tool for characterizing human platelet pathophysiology; thus a detailed characterization of the
Externí odkaz:
https://doaj.org/article/14310a91d0e74aff9e4e5f25ab057422
Autor:
Shane P. Comer, Ana Le Chevillier, Paulina B. Szklanna, Sarah Kelliher, Khalid Saeed, Steven Cullen, Osasere Edebiri, Tiina O'Neill, Niamh Stephens, Luisa Weiss, Claire A. Murphy, Saraswathi Rajakumar, Alexandra Tierney, Conor Hughes, Áine Lennon, Niamh Moran, Patricia B. Maguire, Fionnuala Ní Áinle, Barry Kevane
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundVaccine-induced thrombotic thrombocytopenia (VITT) post SARS-CoV-2 vaccination is characterized by thrombocytopenia and severe thrombosis. Platelet function during patient recovery in the medium-/long-term has not been investigated fully. H
Externí odkaz:
https://doaj.org/article/e43da276dd40457692b1c34616144286
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1009037 (2021)
Graph representations are traditionally used to represent protein structures in sequence design protocols in which the protein backbone conformation is known. This infrequently extends to machine learning projects: existing graph convolution algorith
Externí odkaz:
https://doaj.org/article/ae2e6f980baa4986ab84f8a0397965c3
Autor:
Paulina B. Szklanna, Haidar Altaie, Shane P. Comer, Sarah Cullivan, Sarah Kelliher, Luisa Weiss, John Curran, Emmet Dowling, Katherine M. A. O'Reilly, Aoife G. Cotter, Brian Marsh, Sean Gaine, Nick Power, Áine Lennon, Brian McCullagh, Fionnuala Ní Áinle, Barry Kevane, Patricia B. Maguire
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
To date, coronavirus disease 2019 (COVID-19) has affected over 100 million people globally. COVID-19 can present with a variety of different symptoms leading to manifestation of disease ranging from mild cases to a life-threatening condition requirin
Externí odkaz:
https://doaj.org/article/957d82295fb24aafa305e7006afba53e
Autor:
Sarah Cullivan, Claire A. Murphy, Luisa Weiss, Shane P. Comer, Barry Kevane, Brian McCullagh, Patricia B. Maguire, Fionnuala Ní Ainle, Sean P. Gaine
Publikováno v:
Pulmonary Circulation, Vol 11 (2021)
Pulmonary arterial hypertension is a rare disease of the pulmonary vasculature, characterised pathologically by proliferation, remodelling and thrombosis in situ . Unfortunately, existing therapeutic interventions do not reverse these findings and th
Externí odkaz:
https://doaj.org/article/3123a8955da5418ba1b4d6a5adc91a19
Autor:
Shane P Comer, Sarah Cullivan, Paulina B Szklanna, Luisa Weiss, Steven Cullen, Sarah Kelliher, Albert Smolenski, Claire Murphy, Haidar Altaie, John Curran, Katherine O'Reilly, Aoife G Cotter, Brian Marsh, Sean Gaine, Patrick Mallon, Brian McCullagh, Niamh Moran, Fionnuala Ní Áinle, Barry Kevane, Patricia B Maguire, COCOON Study investigators
Publikováno v:
PLoS Biology, Vol 19, Iss 2, p e3001109 (2021)
Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has affected over 30 million globally to date. Although high rates of venous thromboembolism and evidence of COVID-19-induced endot
Externí odkaz:
https://doaj.org/article/accff9fda6ad4f21a599f41124fa2796