Zobrazeno 1 - 10
of 552
pro vyhledávání: '"B. Lombard"'
Autor:
Taolin Yuan, Surinder Kumar, Mary E. Skinner, Ryan Victor-Joseph, Majd Abuaita, Jaap Keijer, Jessica Zhang, Thaddeus J. Kunkel, Yanghan Liu, Elyse M. Petrunak, Thomas L. Saunders, Andrew P. Lieberman, Jeanne A. Stuckey, Nouri Neamati, Fathiya Al-Murshedi, Majid Alfadhel, Johannes N. Spelbrink, Richard Rodenburg, Vincent C.J. de Boer, David B. Lombard
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109991- (2024)
Summary: SIRT5 is a sirtuin deacylase that removes negatively charged lysine modifications, in the mitochondrial matrix and elsewhere in the cell. In benign cells and mouse models, under basal conditions, the phenotypes of SIRT5 deficiency are quite
Externí odkaz:
https://doaj.org/article/1b3e08c25bb044469b8c3e5f02f889fd
Autor:
Jingyuan Sun, Pei Li, Honglian Gui, Laure Rittié, David B. Lombard, Katrin Rietscher, Thomas M. Magin, Qing Xie, Li Liu, M. Bishr Omary
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Keratin (K) and other intermediate filament (IF) protein mutations at conserved arginines disrupt keratin filaments into aggregates and cause human epidermolysis bullosa simplex (EBS; K14-R125C) or predispose to mouse liver injury (K18-R90C). The cha
Externí odkaz:
https://doaj.org/article/6e147275c606494284720d71e3764a41
Autor:
Samuel A Kerk, Lin Lin, Amy L Myers, Damien J Sutton, Anthony Andren, Peter Sajjakulnukit, Li Zhang, Yaqing Zhang, Jennifer A Jiménez, Barbara S Nelson, Brandon Chen, Anthony Robinson, Galloway Thurston, Samantha B Kemp, Nina G Steele, Megan T Hoffman, Hui-Ju Wen, Daniel Long, Sarah E Ackenhusen, Johanna Ramos, Xiaohua Gao, Zeribe C Nwosu, Stefanie Galban, Christopher J Halbrook, David B Lombard, David R Piwnica-Worms, Haoqiang Ying, Marina Pasca di Magliano, Howard C Crawford, Yatrik M Shah, Costas A Lyssiotis
Publikováno v:
eLife, Vol 11 (2022)
Mitochondrial glutamate-oxaloacetate transaminase 2 (GOT2) is part of the malate-aspartate shuttle, a mechanism by which cells transfer reducing equivalents from the cytosol to the mitochondria. GOT2 is a key component of mutant KRAS (KRAS*)-mediated
Externí odkaz:
https://doaj.org/article/3f6b7faa3ebf44d494617d12f6cd6c1c
Autor:
Benjamin Suenkel, Sergio Valente, Clemens Zwergel, Sandra Weiss, Elisabetta Di Bello, Rossella Fioravanti, Michele Aventaggiato, João A. Amorim, Neha Garg, Surinder Kumar, David B. Lombard, Tuo Hu, Pankaj K. Singh, Marco Tafani, Carlos M. Palmeira, David Sinclair, Antonello Mai, Clemens Steegborn
Publikováno v:
Journal of medicinal chemistry. 65(20)
Sirtuins are NAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afd0c8aa27ecec7cea363831015b0c9
https://pubmed.ncbi.nlm.nih.gov/36228194
https://pubmed.ncbi.nlm.nih.gov/36228194
Publikováno v:
Australian and New Zealand Journal of Public Health, Vol 41, Iss 2, Pp 158-164 (2017)
Abstract Objective: Obesity is a major public health concern and women living in rural settings present a high‐risk group. With contributing factors poorly explored, we evaluated their association with weight in rural Australian women. Methods: Wom
Externí odkaz:
https://doaj.org/article/4ba73ad46da14e71bf962825af8e7b93
Autor:
Ilana Chefetz, Edward Grimley, Kun Yang, Linda Hong, Ekaterina V. Vinogradova, Radu Suciu, Ilya Kovalenko, David Karnak, Cynthia A. Morgan, Mikhail Chtcherbinine, Cameron Buchman, Brandt Huddle, Scott Barraza, Meredith Morgan, Kara A. Bernstein, Euisik Yoon, David B. Lombard, Andrea Bild, Geeta Mehta, Iris Romero, Chun-Yi Chiang, Charles Landen, Benjamin Cravatt, Thomas D. Hurley, Scott D. Larsen, Ronald J. Buckanovich
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 3061-3075.e6 (2019)
Summary: Ovarian cancer is typified by the development of chemotherapy resistance. Chemotherapy resistance is associated with high aldehyde dehydrogenase (ALDH) enzymatic activity, increased cancer “stemness,” and expression of the stem cell mark
Externí odkaz:
https://doaj.org/article/21d10f5934934f7c8c9e8ddf07b5d168
Autor:
Adriana P Rebelo, Pedro J Tomaselli, Jessica Medina, Ying Wang, Maike Dohrn, Eva Nyvltova, Matt Denzi, Mark Garrett, Sean Smith, Alan Pestronk, ChengCheng Li, Ariel Ruiz, Elizabeth Jacobs, Shawna M E Feely, Marcondes C França, Marcus V Gomes, Diogo Santos, Surinder Kumar, David B Lombard, Mario Saporta, Siegfried Hekimi, Antonio Barrientos, Conrad Weihl, Michael Shy, Wilson Marques, Stephan Zuchner
Publikováno v:
Brain.
COQ7 encodes a hydroxylase responsible for the penultimate step of coenzyme Q10 (CoQ10) biosynthesis in mitochondria. CoQ10 is essential for multiple cellular functions, including mitochondrial oxidative phosphorylation, lipid metabolism, and reactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f54e4fb3daa047213cac418873ee1a41
https://doi.org/10.1093/brain/awad158
https://doi.org/10.1093/brain/awad158
Autor:
Emily A. DeBoy, Michael G. Tassia, Kristen E. Schratz, Stephanie M. Yan, Zoe L. Cosner, Emily J. McNally, Dustin L. Gable, Zhimin Xiang, David B. Lombard, Emmanuel S. Antonarakis, Christopher D. Gocke, Rajiv C. McCoy, Mary Armanios
Publikováno v:
New England Journal of Medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa3d9487cef0728d33ce5018f158b512
https://doi.org/10.1056/nejmoa2300503
https://doi.org/10.1056/nejmoa2300503
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Akademický článek
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