Zobrazeno 1 - 10
of 159
pro vyhledávání: '"B. Levy-Wilson"'
Publikováno v:
Journal of Lipid Research, Vol 37, Iss 10, Pp 2117-2124 (1996)
The human apolipoprotein B (apoB) gene resides in a 47.5 kb DNasel-sensitive chromosomal domain in hepatic and intestinal cells, flanked by the 5' distal matrix association region (MAR) and the 3' proximal MAR. A third MAR, the 5' proximal MAR, is fo
Externí odkaz:
https://doaj.org/article/5af9dc66e07748aead303fc4364eba56
Publikováno v:
Journal of Lipid Research, Vol 32, Iss 1, Pp 137-145 (1991)
A 443-base pair fragment (+622 to +1064) from the second intron of the human apolipoprotein B gene was shown to contain a tissue-specific enhancer when placed in front of an apolipoprotein B promoter-chloramphenicol acetyltransferase construct in tra
Externí odkaz:
https://doaj.org/article/95d28129aa204f98826a47434d75bedb
Publikováno v:
Molecular and Cellular Biology. 14:2243-2256
To identify DNA sequence elements from the human apolipoprotein B (apoB) gene required for high-level, correct tissue-specific expression in transgenic mice, we made several constructs that included one or more of the key regulatory elements that wer
Publikováno v:
Journal of Biological Chemistry. 267:18735-18743
The positions of several DNase I-hypersensitive (DH) sites have been mapped in the second and third introns of the human apolipoprotein B gene. Two such DH sites, I and V, are present both in human hepatoma (HepG2) and colon carcinoma (CaCo-2) cells
Autor:
A R Brooks, B Levy-Wilson
Publikováno v:
Molecular and Cellular Biology. 12:1134-1148
The tissue-specific transcriptional enhancer of the human apolipoprotein B gene contains multiple protein-binding sites spanning 718 bp. Most of the enhancer activity is found in a 443-bp fragment (+621 to +1064) that is located entirely within the s
Autor:
B Levy-Wilson, B Paulweber
Publikováno v:
Journal of Biological Chemistry. 266:24161-24168
In the preceding paper (Paulweber, B., Onasch, M. A., Nagy, B. P., and Levy-Wilson, B. (1991) J. Biol. Chem. 266, 24149-24160) we demonstrated that the segment of the apolipoprotein B promoter extending from -260 to -85 is functionally different in h
Publikováno v:
Journal of Biological Chemistry. 266:24149-24160
The arrangement of regulatory elements along the apolipoprotein B promoter region (positions -898 to +1) has been examined in transient transfection experiments performed in HepG2 and Hep3B (hepatic) and CaCo-2 (intestinal) cell lines, all of which e
Publikováno v:
Journal of Biological Chemistry. 266:21956-21961
We have identified a negative regulatory region between positions -1802 and -3211 of the human apolipoprotein B gene that reduces expression of the gene. This "reducer" effect was detected in transient transfection experiments performed with hepatic
Publikováno v:
Journal of Biological Chemistry. 266:7848-7859
We report the identification and characterization of tissue-specific transcriptional enhancer elements that influence the expression of the human apolipoprotein B gene. A 704-base pair PstI fragment comprising sequences from the first and second intr
Autor:
B. Levy-Wilson
Publikováno v:
Biochemical and Biophysical Research Communications. 171:162-168
The chromatin structure of the 3′ end of the human apolipoprotein B gene has been examined. Two DNaseI hypersensitive sites were present in nuclei from liver-derived HepG2 cells and intestine-derived CaCo-2 cells, in which the apo-B gene is transcr