Zobrazeno 1 - 10
of 17
pro vyhledávání: '"B. L. Tepperman"'
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 295(3)
The role of protein kinase C (PKC) in lipopolysaccharide (LPS)- and phorbol ester-induced changes in rat colonic cellular integrity and Ca(2+)-independent inducible nitric-oxide synthase (iNOS) activity was investigated. LPS treatment (3 mg kg(-1) i.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6dd05a7035531f7fa7f119ca39ea9e7
https://pubmed.ncbi.nlm.nih.gov/11082462
https://pubmed.ncbi.nlm.nih.gov/11082462
Autor:
B. L. Tepperman, B. J. R. Whittle
Publikováno v:
Drug Development ISBN: 9781617370878
Over the past decade, nitric oxide (NO) has been shown to play an unprecedented range of roles in biological systems. Diverse physiologic and pathophysiologic roles for NO have been identified, including those of a vasodilator, neurotransmitter, anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44839e7d0a0780b7331be6a01608d08d
https://doi.org/10.1007/978-1-59259-202-9_2
https://doi.org/10.1007/978-1-59259-202-9_2
Publikováno v:
British journal of pharmacology. 128(6)
1 The role of protein kinase C (PKC) in colonic cellular injury in response to high concentrations of nitric oxide (NO) released from the donor, S-nitroso-N-acetyl-DL-penicillamine (SNAP) was investigated. 2 Addition of SNAP (0.1-1000 microM) to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ac9fa239cb5b6119332fe359cddd9620
https://pubmed.ncbi.nlm.nih.gov/10578141
https://pubmed.ncbi.nlm.nih.gov/10578141
Autor:
B L, Tepperman, B D, Soper
Publikováno v:
Digestive diseases and sciences. 44(3)
Although transient increases in intracellular Ca2+ ([Ca2+]i) underlie a number of important physiological processes, sustained elevations in [Ca2+]i mediate damage to a number of tissues and cell types including gastric mucosal cells. Increases in [C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75b2a2195c57d4ce5e46a9990fd9b6c8
https://pubmed.ncbi.nlm.nih.gov/10080140
https://pubmed.ncbi.nlm.nih.gov/10080140
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 284(3)
In our study we have examined the importance of cyclic guanylate monophosphate (cGMP) in NO-mediated intestinal cellular damage. Epithelial cells were harvested from a 20-cm segment of rat proximal small intestine by dispersion using citrate and ethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84060625a826e967f42edc535044a4c5
https://pubmed.ncbi.nlm.nih.gov/9495851
https://pubmed.ncbi.nlm.nih.gov/9495851
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 271(3)
The present study has examined whether epithelial cells could be a source of the inducible form of nitric oxide synthase (iNOS) in the colon of rats challenged with E. coli lipopolysaccharide and whether such excessive endogenous nitric oxide (NO) or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0cc155c36c7452a326267555dd6aca1
https://pubmed.ncbi.nlm.nih.gov/7527855
https://pubmed.ncbi.nlm.nih.gov/7527855
Publikováno v:
Circulatory shock. 42(3)
The objective of this study was to correlate nitric oxide production with time of reperfusion of the post-ischemic feline small intestine. Epithelial permeability, quantitated as blood-to-lumen clearance of 51Cr-EDTA, following 1 hr of ischemia and 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e9f929d46e94c8fc88f845ed5a672f4
https://pubmed.ncbi.nlm.nih.gov/8025978
https://pubmed.ncbi.nlm.nih.gov/8025978
Publikováno v:
The American journal of physiology. 261(1 Pt 1)
The effects of Ca(2+)-modifying agents on the disruption of gastric isolated mucosal cells from the rabbit have been examined. Fundic mucosal cells were isolated and enriched by centrifugal elutriation, with cellular viability and disruption being as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c1cd2fcc8f20b393d59ae2141ca3b3
https://pubmed.ncbi.nlm.nih.gov/1713415
https://pubmed.ncbi.nlm.nih.gov/1713415
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 250:G617-G624
Gastric mucosal responses to intraluminal instillation of acid (10, 50, and 150 mM HCl) and acidified solutions of sodium taurocholate (10 mM) were measured in rats between 5 and 60 days after birth. Net loss of H+ and gain of Na+, K+, and protein in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d465a40cc54f1c7f961d2739f2150282
https://doi.org/10.1152/ajpgi.1986.250.5.g617
https://doi.org/10.1152/ajpgi.1986.250.5.g617
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 52:469-482
The action of a number of nerve-blocking agents on gastric secretion in fundic pouches in dogs has been investigated. Histamine has been used as a direct acid stimulant, and was compared with gastrin and derivatives whose action may involve local ner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1fbce78a2f399f8e7842554e58a92a
https://doi.org/10.1139/y74-063
https://doi.org/10.1139/y74-063