Zobrazeno 1 - 10
of 25
pro vyhledávání: '"B. L. Samuels"'
Autor:
S. M. Griffies, A. Gnanadesikan, K. W. Dixon, J. P. Dunne, R. Gerdes, M. J. Harrison, A. Rosati, J. L. Russell, B. L. Samuels, M. J. Spelman, M. Winton, R. Zhang
Publikováno v:
Ocean Science, Vol 1, Iss 1, Pp 45-79 (2005)
This paper summarizes the formulation of the ocean component to the Geophysical Fluid Dynamics Laboratory's (GFDL) climate model used for the 4th IPCC Assessment (AR4) of global climate change. In particular, it reviews the numerical schemes and phys
Externí odkaz:
https://doaj.org/article/a329161b16824217abe77a7fc1aa2d7c
Publikováno v:
Annals of Oncology. 5:S1-S3
Autor:
B L, Samuels, D R, Hollis, G L, Rosner, D L, Trump, C L, Shapiro, N J, Vogelzang, R L, Schilsky
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 3(11)
Multidrug resistance mediated by P-glycoprotein may be an important cause of chemotherapy failure. Renal cell carcinoma is a disease known to demonstrate a high degree of intrinsic chemotherapy drug resistance, and this has been shown to be related t
Autor:
B L, Samuels, J E, Herndon, D C, Harmon, R, Carey, J, Aisner, J M, Corson, Y, Suzuki, M R, Green, N J, Vogelzang
Publikováno v:
Cancer. 82(8)
In a prior Cancer and Leukemia Group B (CALGB) Phase II trial of patients with advanced, previously untreated mesothelioma, dihydro-5-azacytidine (DHAC) demonstrated a 17% response rate, including 1 complete response, with only mild myelosuppression.
Publikováno v:
Seminars in oncology. 25(1 Suppl 2)
Ifosfamide and vinorelbine have demonstrated single-agent activity against advanced non-small cell lung cancer. The dose-limiting toxicity of each agent is myelosuppression. Several trials have studied this combination to determine its toxicity and e
Autor:
P C, Hoffman, G A, Masters, L C, Drinkard, S A, Krauss, B L, Samuels, H M, Golomb, E E, Vokes
Publikováno v:
Seminars in oncology. 23(3 Suppl 6)
Two studies were performed to determine the maximum tolerated dose (MTD) of paclitaxel and vinorelbine, respectively, in combination with a fixed dose of ifosfamide in previously untreated patients with stage IIIB or IV non-small cell lung cancer. Re
Publikováno v:
Seminars in oncology. 23(2 Suppl 5)
Vinorelbine (Navelbine; Burroughs Wellcome Co, Research Triangle Park, NC; Pierre Fabre Medicament, Paris, France), a semisynthetic vinca alkaloid, and ifosfamide have each shown activity as a single agent and in various combination-chemotherapy regi
Publikováno v:
Biochemistry and molecular biology international. 38(2)
Selenocysteine tRNA[Ser]Sec isoacceptors contain the modified nucleotide i6A immediately 3' to the anticodon. Because synthesis of i6A is expected to be inhibited by lovastatin, the status of tRNA[Ser]Sec isoacceptors was examined in human breast car
Autor:
G A, Masters, L C, Drinkard, P C, Hoffman, N, Lane, S, Watson, B L, Samuels, J D, Bitran, H M, Golomb, E E, Vokes
Publikováno v:
The cancer journal from Scientific American. 1(4)
The combination of cisplatin, 5-fluorouracil, and leucovorin (PFL) has been reported to have a 29% response rate in advanced non-small cell lung cancer. Vinorelbine, a semi-synthetic vinca alkaloid, has also been reported to have single-agent activit
Autor:
P C, Hoffman, S A, Krauss, L C, Drinkard, G A, Masters, B L, Samuels, J D, Bitran, H M, Golomb, S, Watson, E E, Vokes
Publikováno v:
Seminars in oncology. 22(4 Suppl 9)
Both paclitaxel and ifosfamide have significant single-agent activity in non-small cell lung cancer. We designed a phase I study combining escalating doses of paclitaxel, administered by 24-hour infusion, with ifosfamide given at a dose of 1.6 g/m2 d