Zobrazeno 1 - 5
of 5
pro vyhledávání: '"B. L. Rhinehart"'
Publikováno v:
Diabetes. 42:1179-1186
Autor:
K. M. Robinson, M. E. Begovic, B. L. Rhinehart, E. W. Heineke, J. B. Ducep, P. R. Kastner, F. N. Marshall, C. Danzin
Publikováno v:
Diabetes. 40:825-830
Publikováno v:
Life sciences. 41(20)
Castanospermine is a potent inhibitor of rat intestinal glycohydrolases in vitro and prevents the hyperglycemic response to an oral sucrose challenge in vivo . Among the glycohydrolases tested, castanospermine was most effective against sucrase with
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 251(1)
Castanospermine-glucosides (CS-glcs) are new compounds which have been evaluated as glycohydrolase inhibitors in rats. 7-O-alpha-D-Glucopyranosyl-CS (7 alpha-glc-CS) and 8 alpha-glc-CS were potent sucrase inhibitors with IC50s of 40 and 30 nM, respec
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 241(3)
MDL 25,637 is a novel compound designed as a transition-state inhibitor of alpha-glucohydrolases. This compound inhibits rat intestinal sucrase, maltase, isomaltase, glucoamylase and trehalase activities at micromolar concentrations. It is a much wea