Zobrazeno 1 - 10
of 11
pro vyhledávání: '"B. L. Libbus"'
Publikováno v:
Cancer genetics and cytogenetics. 46(2)
Folate deficiency is known to induce chromosomal abnormalities. We used a nutritionally folate-deficient Chinese hamster ovary (CHO) cell culture system to examine modulation of chromosome damage by purine or pyrimidine supplementation. The cells wer
Publikováno v:
Canadian Journal of Genetics and Cytology. 16:481-489
Pachytene chromosomes from mammalian primary spermatocytes can be prepared by two new and related techniques. The first involves pretreatment of the dispersed spermatocytes with a mixture of serum and salts followed by a sodium chloride treatment. Th
Autor:
B. L. Libbus, A. W. Schuetz
Publikováno v:
Cell Proliferation. 11:377-391
Initiation and progression of meiosis was followed in dispersed rat testicular cells by flow cytofluorometry and cytology. The DNA content of dissociated testicular cells of rats 6--30 days old, killed at daily intervals, was analysed by flow cytoflu
Autor:
B L, Libbus, A B, Burdick
Publikováno v:
Cytobios. 30(119)
Testicular cells readily grew in cultures of seminiferous tubule fragments derived from adult rat testes. They formed confluent monolayers and continued to grow through four passages. The majority of cells had ultrastructural features characteristic
Autor:
Bettejayne F. Chastenay, B. L. Libbus, J.P. O'Neill, Janice A. Nicklas, Mark Allegretta, L.M. Sullivan, T. C. Hunter, Richard J. Albertini
Publikováno v:
Environmental and molecular mutagenesis. 12(3)
Recent molecular analysis of in vivo-derived hprt mutant T-lymphocytes cloned from human blood show that mutants occurring at the normal frequency (approximately 5 X 10(-6) in healthy young individuals generally represent independent hprt mutations.
Autor:
B. L. Libbus
Publikováno v:
Human genetics. 70(2)
The question of chromosome distribution in the mammalian nucleus is addressed, and data are provided in support of the ordered arrangement of chromosomes in the Chinese hamster spermatocyte. Testicular cells were dispersed and air-dried without prior
Autor:
B L, Libbus, L A, Johnson
Publikováno v:
Cytogenetics and cell genetics. 47(4)
The G-banded karyotype of the creeping vole, Microtus oregoni, prepared from animals trapped in Oregon and Washington, is presented. The two populations had similar autosomal banding patterns but exhibited striking differences in their sex chromosome
Autor:
B L, Libbus, J E, Craighead
Publikováno v:
Cancer research. 48(22)
Cytogenetic analysis was conducted on cells of 15 rat mesotheliomas induced in rats by the i.p. inoculation of crocidolite or chrysotile asbestos. These tumor cells were diploid, triploid, or tetraploid. All tumor lines exhibited aneuploidy and marke
Publikováno v:
Cancer research. 49(20)
Asbestos, a proven carcinogen, is reported to have no genotoxic effects. We hypothesized, however, in light of its clastogenic effects that one mechanism by which asbestos induces cell transformation and tumorigenesis involves the induction of DNA st
Autor:
A W Schuetz, B L Libbus
Publikováno v:
Journal of reproduction and fertility. 60(1)
Male rats injected with 50 micrograms oestradiol dipropionate every 5 days from birth were given daily injections of 20 i.u. PMSG from 20 to 29 days of age. Testicular weight and cell number remained relatively constant in rats treated only with oest