Zobrazeno 1 - 10 of 11 pro vyhledávání: '"B. L. Daugherty"'
1
Sequencing and bacterial expression of a novel murine alpha interferon gene
Autor: Mingnan Zhou, Lanying Sun, B. L. Daugherty, Ju’e Cai, Zhengyu Wang, Sidney Pestka, Yan Wang, Xinyuan Liu
Publikováno v: Science in China Series C: Life Sciences. 40:277-283
A murine new alpha interferon gene (mIFN-alphaB) was found by primer-based sequencing method in a murine genomic DNA library. The gene was cloned and its sequence was determined. It was expressed inEscherichia coli under the control of the P(L) promo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf42fa4ca2dc7e769c2194ecf4e5d2a
https://doi.org/10.1007/bf02879088
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2
Optimal humanization of 1B4, an anti-CD18 murine monoclonal antibody, is achieved by correct choice of human V-region framework sequences
Autor: I I Singer, D W Kawka, J A DeMartino, B L Daugherty, K O Elliston, K Alves, B L Bush, P M Cameron, G C Cuca, P Davies
Publikováno v: The Journal of Immunology. 150:2844-2857
The murine anti-CD18 mAb 1B4 has been humanized using CDR grafting. Three VH (Gal, Jon, and New) and two VL (Rei and Len) human frameworks, whose selection was based exclusively on their sequence identity with m1B4, were used to construct five human
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76cb22d48c125731dcbf43ce40c99f69
https://doi.org/10.4049/jimmunol.150.7.2844
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3
Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing
Autor: B L, Daugherty, S A, Green
Publikováno v: Traffic (Copenhagen, Denmark). 2(12)
Amyloid beta protein, the major component of the senile plaques in Alzheimer's disease, is generated by secretory and endocytic processing of amyloid precursor protein. Internalized amyloid precursor protein either recycles to the plasma membrane, wh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e08d211a6dd77f6b3e99ed2bbb0b1438
https://pubmed.ncbi.nlm.nih.gov/11737828
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4
AP-3 adaptor functions in targeting P-selectin to secretory granules in endothelial cells
Autor: B L, Daugherty, K S, Straley, J M, Sanders, J W, Phillips, M, Disdier, R P, McEver, S A, Green
Publikováno v: Traffic (Copenhagen, Denmark). 2(6)
P-selectin, a cell adhesion protein participating in the early stages of inflammation, contains multiple sorting signals that regulate its cell surface expression. Targeting to secretory granules regulates delivery of P-selectin to the cell surface.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::131b6da70eed9e621b7d1d982a2b00c7
https://pubmed.ncbi.nlm.nih.gov/11389768
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5
Analysis of the CC chemokine receptor 3 gene reveals a complex 5' exon organization, a functional role for untranslated exon 1, and a broadly active promoter with eosinophil-selective elements
Autor: N, Zimmermann, B L, Daugherty, J L, Kavanaugh, F Y, El-Awar, E A, Moulton, M E, Rothenberg
Publikováno v: Blood. 96(7)
To understand the regulation of CC chemokine receptor 3 (CCR3) expression, its gene structure and promoter have been characterized. The CCR3 gene contains 4 exons that give rise to multiple messenger RNA (mRNA) species by alternative splicing. Exon 1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62768a709013f19d6538690f65d512a0
https://pubmed.ncbi.nlm.nih.gov/11001881
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7
Expression of recombinant human anti-MAG antibodies in non-lymphoid mammalian cells
Autor: L A, Spatz, B L, Daugherty, J A, DeMartino, G E, Mark, N, Latov
Publikováno v: Human antibodies and hybridomas. 3(2)
The variable heavy and light chain genes of a monoclonal, IgM, anti-MAG antibody from a patient with neuropathy were inserted into expression vectors containing the gamma and kappa constant regions respectively and co-transfected into monkey kidney C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::47c0d25f8e2a85bce93f257b67dffc95
https://pubmed.ncbi.nlm.nih.gov/1378765
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8
Expression of human interferon alpha H, an interferon with two potential asparagine-linked glycosylation sites
Autor: X X, Zhao, B L, Daugherty, B, Schwartz, S, Maeda, S, Pestka
Publikováno v: Journal of biological regulators and homeostatic agents. 1(3)
Of the large number of human alpha interferon genes identified, only one, Hu-IFN-alpha H, contains potential asparagine-linked glycosylation sites. With the use of a new vector that permits convenient expression, site-specific mutation, and DNA seque
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::386b962dbc38ac7059e87ad40ec314ca
https://pubmed.ncbi.nlm.nih.gov/3332544
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9
Anti-mRNA: specific inhibition of translation of single mRNA molecules
Autor: R K Pestka, Sidney Pestka, B L Daugherty, V Jung, K Hotta
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 81(23)
A plasmid was constructed to generate RNA complementary to the beta-galactosidase mRNA under control of the phage lambda PL promoter. When this anti-mRNA was produced, synthesis of beta-galactosidase was dramatically inhibited (98%). Syntheses of gal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ae382c1ce773fb0ea85893b1fcdfd6
https://pubmed.ncbi.nlm.nih.gov/6438637
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