Denufosol Tetrasodium in Patients with Cystic Fibrosis and Normal to Mildly Impaired Lung Function

Autor: A. Robles, Karen A. Hardy, Clement L. Ren, R. Anbar, James F. Chmiel, V. Roberts, Allen J. Dozor, D. Schellhase, A. Horn, Drucy Borowitz, Marlyn S. Woo, G. Drapeau, D. Delute, P. Olson, Robin R. Deterding, David E. Geller, T. Brascia, Ran D. Anbar, Ronald C. Rubenstein, Susan L. Millard, Theodore G. Liou, R. Lee, Steven R. Boas, P. Fornos, Jonathan B. Zuckerman, S. Galvin, L. Duan, I. Gherson, M.S. Howenstine, J. Kreindler, Christopher M. Oermann, C. Dunn, K. Jones, C. Prestidge, Jamshed F. Kanga, M. Wall, David Schaeffer, Bradley E. Chipps, J. Young, Henry L. Dorkin, C. Grece, Todd A. Durham, Adrienne Prestridge, Marie E. Egan, P. Walker, Greg R. Elliott, C. Kubrak, D. Heimes, V. Kociela, B. Owsley, E. DeLuca, R. Kennedy-DuDevoir, J. Gadd, D. Cook, C. Barlow, Jordan M. Dunitz, Zoe Davies, C. Murray, Cori L. Daines, Gavin R. Graff, Aaron Chidekel, A. Atlas, M. Dillard, Samya Z. Nasr, Dorothy Bisberg, M. Franco, Michael G. Rock, Yves Berthiaume, A. Guzik, Paula J. Anderson, Donna Beth Willey-Courand, Amy E. Schaberg, R. Moss, Dion Roberts, L. Bendy, Emily DiMango, N. Beaudoin, Ronald L. Gibson, D. Towle, Frank J. Accurso, J. Peabody, P. Pock, John L. Colombo, L. Traplena, Robert W. Wilmott, J. Smith, G. Gong, George Z. Retsch-Bogart, Jamie L. Wooldridge, Joan DeCelie-Germana, L. Makholm, John P. Clancy, C. Lapin, R. Kelly, D. Lindner, Deborah Froh, D. Hicks, Santiago Reyes, A. Genatossio, C. Nakamura, B. Ksenich, Karen McCoy, Richard B. Moss, Richard C. Ahrens, Daniel J. Weiner, Michael S. Schechter, A. Gardner, Pamela L. Zeitlin, Bonnie W. Ramsey

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 183:627-634

Intervention for cystic fibrosis lung disease early in its course has the potential to delay or prevent progressive changes that lead to irreversible airflow obstruction. Denufosol is a novel ion channel regulator designed to correct the ion transpor

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https://doi.org/10.1164/rccm.201008-1267oc