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Treatment with Anakinra improves disposition index but not insulin sensitivity in nondiabetic subjects with the metabolic syndrome: a randomized, double-blind, placebo-controlled study

Autor: Mihai G. Netea, Rinke Stienstra, Edwin J.P. van Asseldonk, Cees J. Tack, Tim B. Koenen, Leo A. B. Joosten

Publikováno v: Journal of Clinical Endocrinology and Metabolism, 96, 7, pp. 2119-26
Journal of Clinical Endocrinology and Metabolism, 96, 2119-26

Contains fulltext : 98491.pdf (Publisher’s version ) (Open Access) CONTEXT: Obesity induces low-grade inflammation that may promote the development of insulin resistance. IL-1 is one of the key inflammatory factors. OBJECTIVE: The objective of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ca187e2181e4917c07735d0445a46e
https://doi.org/10.1210/jc.2010-2992

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Adiponectin multimer distribution in patients with familial combined hyperlipidemia

Autor: Anton F. H. Stalenhoef, Tim B. Koenen, Heidi Lemmers, Martin den Heijer, Suzanne Holewijn, Jacqueline de Graaf, Lambertus J.H. van Tits

Publikováno v: Biochemical and Biophysical Research Communications, 376, 1, pp. 164-8
Biochemical and Biophysical Research Communications, 376, 164-8

Contains fulltext : 69561tits.pdf (Publisher’s version ) (Closed access) Adiponectin is secreted from adipocytes in different multimers, of which the high molecular weight (HMW) form is supposed to mediate favorable metabolic and anti-atherogenic e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac01d6133c3fe946b07e752b607ad2b
https://doi.org/10.1016/j.bbrc.2008.08.111

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Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice

Autor: Tim B. Koenen, Han Gerrits, Dorette S. van Ingen Schenau, Laura S. Hermens, Nicole E. C. Bakker, Ad J.M. van Disseldorp, Jan A. Gossen, Magda A.M. Krajnc-Franken, Ankie M. Strik

Publikováno v: genesis. 46:235-245

CXCR7 is a G-protein coupled receptor that was recently deorphanized and shown to have SDF1 and I-TAC as high affinity ligands. Here we describe the characterization of CXCR7-deficient mice that were generated to further investigate the function of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc5e4426850ae327203698cbfe5850f
https://doi.org/10.1002/dvg.20387

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Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammantory cytokine expression

Autor: H.J. Jansen, Mihai G. Netea, Tim B. Koenen, Cees J. Tack, Rinke Stienstra, P. van Essen, Leo A. B. Joosten

Publikováno v: Endocrinology, 153(12), 5866-5874
Endocrinology 153 (2012) 12
Endocrinology, 153, 5866-74
Endocrinology, 153, 12, pp. 5866-74

Autophagy, an evolutionary conserved process aimed at recycling damaged organelles and protein aggregates in the cell, also modulates proinflammatory cytokine production in peripheral blood mononuclear cells. Because adipose tissue inflammation accom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ba9612181bcea52adacdde9003bc7b
https://research.wur.nl/en/publications/autophagy-activity-is-up-regulated-in-adipose-tissue-of-obese-ind

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The inflammasome and caspase-1 activation: a new mechanism underlying increased inflammatory activity in human visceral adipose tissue

Autor: Rinke Stienstra, Anton F. H. Stalenhoef, Anneke Hijmans, Jacqueline de Graaf, J.A. van der Vliet, Lambertus J.H. van Tits, Cees J. Tack, Leo A. B. Joosten, Jeroen F. van Velzen, Mihai G. Netea, Jillis A. Pol, Tim B. Koenen

Publikováno v: Endocrinology 152 (2011) 10
Endocrinology, 152, 10, pp. 3769-78
Endocrinology, 152, 3769-78
Endocrinology, 152(10), 3769-3778

Contains fulltext : 97441.pdf (Publisher’s version ) (Open Access) The immune competent abdominal adipose tissue, either stored viscerally [visceral adipose tissue (VAT)] or sc [sc adipose tissue (SAT)], has been identified as a source of IL-1beta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee437cb751539e005fbeae6e9d1f7e86
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/97441

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Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue

Autor: Jacqueline de Graaf, Tim B. Koenen, Lambertus J.H. van Tits, Leo A. B. Joosten, Mihai G. Netea, Rinke Stienstra, Cees J. Tack, Anton F. H. Stalenhoef

Publikováno v: Diabetes
Diabetes, 60, 517-24
Diabetes, 60, 2, pp. 517-24

OBJECTIVE Obesity is characterized by elevated levels of proinflammatory cytokines, including interleukin (IL)-1β, that contribute to the development of insulin resistance. In this study, we set out to investigate whether hyperglycemia drives IL-1β

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e20dc69a33d85b0a17276a495e0bff9
https://doi.org/10.2337/db10-0266

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