Zobrazeno 1 - 10
of 479
pro vyhledávání: '"B. Knick"'
Autor:
Mui Cheung, Deirdre K. Luttrell, Jeffrey A. Stafford, Amogh Boloor, Andrea H. Epperly, Anne T. Truesdale, Tona M. Gilmer, Robert J. Mullin, James A. Onori, Laura E. Harrington, Charles G. Miller, Teresa M. Hopper, Ming-Chih Crouthamel, Renae M. Crosby, Jennifer H. Johnson, Sharon K. Rudolph, Victoria B. Knick, Rakesh Kumar
Supplementary Fig. S2 from Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef45f85ad8f9bf67422b660c7c3c6e9f
https://doi.org/10.1158/1535-7163.22486202
https://doi.org/10.1158/1535-7163.22486202
Autor:
Mui Cheung, Deirdre K. Luttrell, Jeffrey A. Stafford, Amogh Boloor, Andrea H. Epperly, Anne T. Truesdale, Tona M. Gilmer, Robert J. Mullin, James A. Onori, Laura E. Harrington, Charles G. Miller, Teresa M. Hopper, Ming-Chih Crouthamel, Renae M. Crosby, Jennifer H. Johnson, Sharon K. Rudolph, Victoria B. Knick, Rakesh Kumar
Supplementary Table S4 from Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59008ace3d1723e484a09b0c7583a1b8
https://doi.org/10.1158/1535-7163.22486187.v1
https://doi.org/10.1158/1535-7163.22486187.v1
Autor:
Mui Cheung, Deirdre K. Luttrell, Jeffrey A. Stafford, Amogh Boloor, Andrea H. Epperly, Anne T. Truesdale, Tona M. Gilmer, Robert J. Mullin, James A. Onori, Laura E. Harrington, Charles G. Miller, Teresa M. Hopper, Ming-Chih Crouthamel, Renae M. Crosby, Jennifer H. Johnson, Sharon K. Rudolph, Victoria B. Knick, Rakesh Kumar
With the development of targeted therapeutics, especially for small-molecule inhibitors, it is important to understand whether the observed in vivo efficacy correlates with the modulation of desired/intended target in vivo. We have developed a small-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a2e897f6576dbb9b6e4c3b0107ed11
https://doi.org/10.1158/1535-7163.c.6532271
https://doi.org/10.1158/1535-7163.c.6532271
Autor:
Rakesh Kumar, Robert A. Copeland, Pearl S. Huang, Edgar R. Wood, Susan L. Strum, Elisabeth A. Minthorn, Jack D. Leber, Zhihong Lai, Anthony E. Choudhry, Elena V. Kleymenova, Robert S. Geske, Jason A. Kahana, Kimberly Robell, Shu-Yun Zhang, Tona M. Gilmer, Randy T. McConnell, Timothy J. Lansing, Victoria B. Knick, Derek J. Eberwein, Derek R. Duckett, Dirk A. Heerding, Nelson Rhodes
Supplementary Methods and Figure Legends 1-2 from Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a3405f44d49aec54206ba52ba0d265
https://doi.org/10.1158/0008-5472.22370963
https://doi.org/10.1158/0008-5472.22370963
Autor:
Rakesh Kumar, Robert A. Copeland, Pearl S. Huang, Edgar R. Wood, Susan L. Strum, Elisabeth A. Minthorn, Jack D. Leber, Zhihong Lai, Anthony E. Choudhry, Elena V. Kleymenova, Robert S. Geske, Jason A. Kahana, Kimberly Robell, Shu-Yun Zhang, Tona M. Gilmer, Randy T. McConnell, Timothy J. Lansing, Victoria B. Knick, Derek J. Eberwein, Derek R. Duckett, Dirk A. Heerding, Nelson Rhodes
Supplementary Figure 2 from Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426e3e38118b83488267a117b29c53cd
https://doi.org/10.1158/0008-5472.22370966
https://doi.org/10.1158/0008-5472.22370966
Autor:
Rakesh Kumar, Robert A. Copeland, Pearl S. Huang, Edgar R. Wood, Susan L. Strum, Elisabeth A. Minthorn, Jack D. Leber, Zhihong Lai, Anthony E. Choudhry, Elena V. Kleymenova, Robert S. Geske, Jason A. Kahana, Kimberly Robell, Shu-Yun Zhang, Tona M. Gilmer, Randy T. McConnell, Timothy J. Lansing, Victoria B. Knick, Derek J. Eberwein, Derek R. Duckett, Dirk A. Heerding, Nelson Rhodes
Supplementary Figure 1 from Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4abec9d184e4e3594165c4dd227e1f2
https://doi.org/10.1158/0008-5472.22370972.v1
https://doi.org/10.1158/0008-5472.22370972.v1
Autor:
Patricia A. Elkins, Ren Xie, Zhihong Lai, Anthony E. Choudhry, Wenyong Wang, Sirishkumar Nidarmarthy, Dennis S. Yamashita, Elisabeth A. Minthorn, Juan I. Luengo, Hong Lin, Nestor O. Concha, Jin Zeng, Nelson Rhodes, Dirk A. Heerding, Edgar R. Wood, Susan L. Strum, Victoria B. Knick
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:673-678
2,3,5-Trisubstituted pyridines have been designed as potent AKT inhibitors that are selective against ROCK1 based on the comparison between AKT and ROCK1 structures. Substitution at the 2-position of the core pyridine is the key element to provide se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e0b61af1e1f4e6775e62a15c5dc870
https://doi.org/10.1016/j.bmcl.2009.11.064
https://doi.org/10.1016/j.bmcl.2009.11.064
Autor:
James Marvin Veal, Robert J. Griffin, Jennifer G. Badiang Alberti, Daniel J. Price, Michael J. Reno, Anne M. Hassell, Michael Robert Peel, Lisa M. Shewchuk, Victoria B. Knick, Stephen T. Davis, Laurie S. Kane-Carson, Kirk L. Stevens
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5758-5762
A novel series of pyrazolo[1,5-b]pyridazines have been synthesized and identified as cyclin dependant kinase inhibitors potentially useful for the treatment of solid tumors. Modification of the hinge-binding amine or the C(2)- and C(6)-substitutions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280a1cb22c5d20e09331ae5b2631e585
https://doi.org/10.1016/j.bmcl.2008.09.069
https://doi.org/10.1016/j.bmcl.2008.09.069
Autor:
Victoria B. Knick, Tona M. Gilmer, Daniel F. Hassler, Masaaki Furuta, Randy T. McConnell, Glenn M. Spehar, Nobuhiro Noro, Kyle A. Emmitte, Robert A. Mook, Timothy J. Lansing, Mui Cheung, Derek R. Duckett
Publikováno v:
Molecular Cancer Therapeutics. 6:450-459
Polo-like kinase 1 (PLK1) plays key roles in the regulation of mitotic progression, including mitotic entry, spindle formation, chromosome segregation, and cytokinesis. PLK1 expression and activity are strongly linked to proliferating cells. Many stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6dc37d8e317417670e30adbaf5906a
https://doi.org/10.1158/1535-7163.mct-06-0543
https://doi.org/10.1158/1535-7163.mct-06-0543