Zobrazeno 1 - 10
of 97
pro vyhledávání: '"B. Knödgen"'
Autor:
Nikolaus Seiler, Christine Grauffel, B. Knödgen, Paula M. Moran, Shakir Sarhan, M van den Buuse, S. Gobaille, J. Elands
Publikováno v:
Pharmacology Biochemistry and Behavior. 50:181-189
Acute and chronic administration of vigabatrin, a selective inactivator of GABA-T, suppresses haloperidol-induced dyskinesias at low doses without preventing the enhancement of striatal dopamine D2 receptor density or the development of vacuous chewi
Publikováno v:
Metabolic Brain Disease. 9:211-224
5-Fluoromethylornithine (5FMOrn) is a selective inactivator of ornithine aminotransferase. Administration of this compound to rodents causes a prominent increase of tissue ornithine concentrations, and prevents the neurological consequences of acute
Publikováno v:
Neurochemical Research. 18:539-549
Repeated administration of thioacetamide (TAA) to CD1 mice produced hepatic failure and biochemical and behavioral effects characteristic of hepatogenic encephalopathy (HE). The symptoms in mice resembled those previously observed in rats after simil
Publikováno v:
Pharmacology & Toxicology. 70:373-380
5-Fluoromethylornithine (5FMOrn) is a selective inactivator of ornithine aminotransferase. Its administration causes a dramatic increase of ornithine concentrations in all tissues. Treatment of mice with 20 mg.kg-1 5FMOrn shortly before or after a le
Publikováno v:
International Journal of Biochemistry. 23:617-626
1. 1. Treatment of mice and rats with the polyamine oxidase inhibitor N 1 ,N 4 -bis-(2,3-butadienyl)- 1, 4-butanediamine (MDL 72527) causes a gradual accumulation of spennine in the circulation and a decrease of spennidine concentration. 2. 2. Spenni
Publikováno v:
Neurochemical Research. 15:301-305
The method for the assay of glutamine synthetase (GlnS) relies on the gamma-glutamyl transferase reaction, i.e. the formation of glutamyl-gamma-hydroxamate from glutamine and hydroxylamine, and the chromatographic separation of the reaction product f
Publikováno v:
Research in immunology. 145(4)
Ammonia is a natural lysosomotropic compound. Concentrations of ammonium acetate > 2 mM impaired the phagocytic activity of BV-2 cells, an immortalized microglial cell line, as was determined by the uptake of fluorescent latex microspheres of differe
Publikováno v:
Journal of inherited metabolic disease. 17(6)
Mice with the X-chromosomal sparse-fur (spf) mutation are an animal model of some hereditary deficiencies of ornithine carbamoyltransferase (OCT) in man. Orotic aciduria and hyperammonaemia are the most conspicuous metabolic changes in these diseases
Publikováno v:
Anticancer research. 12(2)
Feeding an artificial, essentially polyamine-free diet which contained antibiotics for the decontamination of the gastrointestinal tract and 2-(difluoromethyl)ornithine (DFMO) and N,N'-bis-(2,3-butadienyl)putrescine for the inactivation of ornithine
Publikováno v:
Cancer research. 50(16)
The combination of inhibitors of ornithine decarboxylase and polyamine oxidase and of antibiotics suitable for the (partial) decontamination of the gastrointestinal tract with a polyamine-deficient diet reduced the growth rate of Lewis lung carcinoma