Zobrazeno 1 - 10
of 35
pro vyhledávání: '"B. Kenneth Koe"'
Autor:
Patricia A. Seymour, Desai Kishor A, B. Kenneth Koe, David H. Blank, Carol B. Fox, Macor John E, Anne W. Schmidt, David W. Schulz, Ronald J. Post, Lorraine A. Lebel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2391-2396
The discovery of CP-161,242 (5-cyano-1-[3-(N-methylpyrrolidin-2R-ylmethyl)indol-5-yl]benzimidazole), a potent, selective, orally active central serotonin (5-HT1D) agonist [IC50 (binding) = 1.3 nM, EC50 (inhibition of adenylate cyclase) = 42 pM] and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::babecb78f7d9c13cd636bdf0f868a836
https://doi.org/10.1016/0960-894x(95)00417-r
https://doi.org/10.1016/0960-894x(95)00417-r
Publikováno v:
Drug Development Research. 33:413-421
In the search for novel serotonin receptor ligands, a series of 5-thiazolyl-N,N-dimethyltryptamine derivatives was synthesized which exhibited high affinity binding to 5-HT1A, 5-HT1B, and 5-HT1D receptors and the functional characteristics of recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acbae4e9a5a75cd79c13560979a3c1a0
https://doi.org/10.1002/ddr.430330404
https://doi.org/10.1002/ddr.430330404
Autor:
B. Kenneth Koe, Lorraine A. Lebel
Publikováno v:
Drug Development Research. 27:253-264
Binding studies in rat brain membranes have shown that [3H]CP-96,501 is a selective, high affinity radioligand for 5-HT1B receptors. Additional studies with [3H]CP-96,501 in brain tissues of several other species were undertaken to investigate its ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a96798fc3421569d94275f303803dc5d
https://doi.org/10.1002/ddr.430270305
https://doi.org/10.1002/ddr.430270305
Publikováno v:
Drug Development Research. 25:67-74
3-(1,2,5,6-Tetrahydro-4-pyridyl)-5-pyrrolo[3,2-b]pyridone, CP-93, 129, is a selective agonist ligand for 5-HT1B receptors. High affinity binding sites of [3H]CP-93, 129 were found in rat whole brain membranes, which showed KD and Bmax values similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ae438a27e5b5261ad6f9e94830feb8e
https://doi.org/10.1002/ddr.430250107
https://doi.org/10.1002/ddr.430250107
Autor:
Lorraine A. Lebel, James C. Windels, Carol A. Burkhart, B. Kenneth Koe, Macor John E, Phillip M. Chalabi, Robert W. Roth
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 29:249-257
The synthesis of [3H]CP-96,501 [5-(2,3-ditritiopropoxy)-3-(1,2,5,6-tetrahydropyrid-4-yl)indole], a selective radioligand for the serotonin (5-HT1B) receptor and analog of RU-24,969, is described. 5-Hydroxyindole is converted in two steps to 5-(2-prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb4c71844be772d8cc12e854913823e3
https://doi.org/10.1002/jlcr.2580290302
https://doi.org/10.1002/jlcr.2580290302
Autor:
Frederic J. Vinick, David L. Helweg, Lorraine A. Lebel, J. A. Nielsen, Jeffery L. Ives, Stanley Jung, Douglas C. Chapin, Phillips Douglas, Lorena L. Russo, Peter F. Thadieo, Nicholas A. Saccomano, Ian H. Williams, William M. Whalen, B. Kenneth Koe, Jonathan L. Johnson, Morgan Meltz
Publikováno v:
Journal of Medicinal Chemistry. 34:291-298
The synthesis and biological properties of a novel series of selective calcium-independent phosphodiesterase inhibitors are described. These compounds also inhibit the specific binding of [3H]rolipram to rat brain membranes and exhibit efficacy in pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ab8003e9c4acfdc5c40c3d13f2db7a
https://doi.org/10.1021/jm00105a045
https://doi.org/10.1021/jm00105a045
Autor:
B. Kenneth Koe, Lorraine A. Lebel, Lorena L. Russo, J. A. Nielsen, Nicholas A. Saccomano, Ian H. Williams, Fredric J. Vinick
Publikováno v:
Drug Development Research. 21:135-142
A series of new catechol ether imidazolidinones incorporating structural features of rolipram and Ro 20-1724 were synthesized as inhibitors of the calcium-independent phosphodiesterase (IPDE) from rat cerebral cortex. Several compounds were found to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a2c0420d38a7865183cf635e6d08157
https://doi.org/10.1002/ddr.430210206
https://doi.org/10.1002/ddr.430210206
Autor:
B. Kenneth Koe
Publikováno v:
Marihuana and Medicine ISBN: 9781475757170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea65e5257d2d70321ee732a37353b9cf
https://doi.org/10.1007/978-1-59259-710-9_53
https://doi.org/10.1007/978-1-59259-710-9_53
Autor:
Fredric J. Vinick, Nicholas A. Saccomano, B. Kenneth Koe, Jann A. Nielsen, Ian H. Williams, Peter F. Thadeio, Stanley Jung, Morgan Meltz, Jonathan Johnson, Lorraine A. Lebel, Lorena L. Russo, David Helweg
Publikováno v:
Journal of medicinal chemistry. 34(1)
The synthesis and biological properties of a series of nicotinamide ethers are described. These compounds, structurally novel calcium-independent phosphodiesterase inhibitors, also inhibit the binding of [ 3 H]rolipram to rat brain membranes and reve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8a21918f3d408b2230b73d3c3ea81a
https://pubmed.ncbi.nlm.nih.gov/1825116
https://pubmed.ncbi.nlm.nih.gov/1825116
Publikováno v:
Drug Development Research. 7:255-268
Methaqualone and mecloqualone were found to inhibit [3H]diazepam binding to rat cortical membranes, whereas a related quinazolinone, piriqualone (3-(2-methylphenyl)-2-[2-(2-pyridinyl)ethenyl]-4(3H)-quinazolinone), elicited an increase in the binding.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f98ec98fd699a9dfda3021120acbb16d
https://doi.org/10.1002/ddr.430070307
https://doi.org/10.1002/ddr.430070307