Zobrazeno 1 - 10
of 85
pro vyhledávání: '"B. Kellett"'
Autor:
J. Duplissy, M. B. Enghoff, K. L. Aplin, F. Arnold, H. Aufmhoff, M. Avngaard, U. Baltensperger, T. Bondo, R. Bingham, K. Carslaw, J. Curtius, A. David, B. Fastrup, S. Gagné, F. Hahn, R. G. Harrison, B. Kellett, J. Kirkby, M. Kulmala, L. Laakso, A. Laaksonen, E. Lillestol, M. Lockwood, J. Mäkelä, V. Makhmutov, N. D. Marsh, T. Nieminen, A. Onnela, E. Pedersen, J. O. P. Pedersen, J. Polny, U. Reichl, J. H. Seinfeld, M. Sipilä, Y. Stozhkov, F. Stratmann, H. Svensmark, J. Svensmark, R. Veenhof, B. Verheggen, Y. Viisanen, P. E. Wagner, G. Wehrle, E. Weingartner, H. Wex, M. Wilhelmsson, P. M. Winkler
Publikováno v:
Atmospheric Chemistry and Physics, Vol 10, Iss 4, Pp 1635-1647 (2010)
During a 4-week run in October–November 2006, a pilot experiment was performed at the CERN Proton Synchrotron in preparation for the Cosmics Leaving OUtdoor Droplets (CLOUD) experiment, whose aim is to study the possible influence of cosmic rays on
Externí odkaz:
https://doaj.org/article/b11e60b56ffb42aa86c554b9922db884
Publikováno v:
Annales Geophysicae, Vol 22, Pp 1033-1046 (2004)
We study here the injection and transport of ions in the convection-dominated region of the Earth's magnetosphere. The total ion counts from the CAMMICE MICS instrument aboard the POLAR spacecraft are used to generate occurrence probability distrib
Externí odkaz:
https://doaj.org/article/a369c26c8ce44a16823e45fe1522d5e5
Publikováno v:
Annales Geophysicae, Vol 19, Pp 1-9 (2001)
Solar wind/magnetosheath plasma in the magnetosphere can be identified using a component that has a higher charge state, lower density and, at least soon after their entry into the magnetosphere, lower energy than plasma from a terrestrial source.
Externí odkaz:
https://doaj.org/article/8e5100a6717f448c83632d43282691b3
Autor:
Isobel J Whitehouse, Deborah Brown, Herbert Baybutt, Abigail B Diack, Katherine A B Kellett, Pedro Piccardo, Jean C Manson, Nigel M Hooper
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159119 (2016)
The cellular prion protein (PrPC) has been proposed to play an important role in the pathogenesis of Alzheimer's disease. In cellular models PrPC inhibited the action of the β-secretase BACE1 on wild type amyloid precursor protein resulting in a red
Externí odkaz:
https://doaj.org/article/661eb766a5da451a8aa047e01b1089fe
Publikováno v:
Neuronal Signaling
The neurovascular unit (NVU), consisting of neurons, glial cells, vascular cells (endothelial cells, pericytes and vascular smooth muscle cells (VSMCs)) together with the surrounding extracellular matrix (ECM), is an important interface between the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdef93861431567d0da4eab9ac3b703b
https://doi.org/10.1042/ns20210027
https://doi.org/10.1042/ns20210027
Autor:
Catherine B. Lawrence, Lana Papafilippou, James Eales, Marilena Hadjidemetriou, Kostas Kostarelos, Nigel M. Hooper, Jack Rivers-Auty, Katherine A. B. Kellett
Publikováno v:
Hadjidemetriou, M, Rivers-Auty, J, Papafilippou, L, Eales, J, Kellett, K A B, Hooper, N M, Lawrence, C B & Kostarelos, K 2021, ' Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer's Disease ', ACS Nano, vol. 15, no. 4, pp. 7357-7369 . https://doi.org/10.1021/acsnano.1c00658
ACS Nano
Papafilippou, T A, Hadjidemetriou, M, Kostarelos, K, Rivers-Auty, J, Hooper, N, Lawrence, C B & Eales, J 2021, ' Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer’s Disease ', ACS Nano, pp. 7357–7369 . https://doi.org/10.1021/acsnano.1c00658
ACS Nano
Papafilippou, T A, Hadjidemetriou, M, Kostarelos, K, Rivers-Auty, J, Hooper, N, Lawrence, C B & Eales, J 2021, ' Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer’s Disease ', ACS Nano, pp. 7357–7369 . https://doi.org/10.1021/acsnano.1c00658
Blood-circulating biomarkers have the potential to detect Alzheimer's disease (AD) pathology before clinical symptoms emerge and to improve the outcomes of clinical trials for disease-modifying therapies. Despite recent advances in understanding conc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd859d253447b068f05de39842ece6e3
https://doi.org/10.1021/acsnano.1c00658
https://doi.org/10.1021/acsnano.1c00658
Publikováno v:
Neurochemical Research
Rowland, H, Hooper, N & Kellett, K 2018, ' Modelling Sporadic Alzheimer’s Disease using Induced Pluripotent Stem Cells ', Neurochemical research . https://doi.org/10.1007/s11064-018-2663-z
Rowland, H, Hooper, N & Kellett, K 2018, ' Modelling Sporadic Alzheimer’s Disease using Induced Pluripotent Stem Cells ', Neurochemical research . https://doi.org/10.1007/s11064-018-2663-z
Developing cellular models of sporadic Alzheimer’s disease (sAD) is challenging due to the unknown initiator of disease onset and the slow disease progression that takes many years to develop in vivo. The use of human induced pluripotent stem cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4453cbeead529ae123ac989c1b0fe7f1
https://doi.org/10.1007/s11064-018-2663-z
https://doi.org/10.1007/s11064-018-2663-z
Autor:
Katherine A. B. Kellett, Sikha Saha, Nadira Yuldasheva, Alasdair R. Pickles, Sabah Khan, Trevor F.C. Batten
Publikováno v:
Neurochemistry International. 118:134-144
Cerebral ischemia is known to be a major cause of death and the later development of Alzheimer's disease and vascular dementia. However, ischemia induced cellular damage that initiates these diseases remain poorly understood. This is primarily due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3417f83df5d5940ff5d44e111fdac467
https://doi.org/10.1016/j.neuint.2018.04.004
https://doi.org/10.1016/j.neuint.2018.04.004
Publikováno v:
Andrew, R J, Kellett, K, Thinakaran, G & Hooper, N 2016, ' A Greek Tragedy: the Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis ', Journal of Biological Chemistry, vol. 291, pp. 19235-19244 . https://doi.org/10.1074/jbc.R116.746032
Proteolysis of the amyloid precursor protein (APP) liberates various fragments including the proposed initiator of Alzheimer disease-associated dysfunctions, amyloid-β. However, recent evidence suggests that the accepted view of APP proteolysis by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80149f838b233450cf70d8de7d546e0
https://doi.org/10.1074/jbc.r116.746032
https://doi.org/10.1074/jbc.r116.746032
Autor:
Daniel S. Greenspan, Kate Fisher, Sreemoti Banerjee, Catherine B. Lawrence, Carolyn D. Jackson, Katherine A. B. Kellett, Christopher J. Duff, Nobuyo Maeda, Nigel M. Hooper, Robert J. Andrew
Publikováno v:
Scientific Reports
Banerjee, S, Andrew, R J, Duff, C J, Fisher, K, Jackson, C D, Lawrence, C B, Maeda, N, Greenspan, D S, Kellett, K & Hooper, N 2019, ' Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake ', Scientific Reports . https://doi.org/10.1038/s41598-019-47814-0
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Banerjee, S, Andrew, R J, Duff, C J, Fisher, K, Jackson, C D, Lawrence, C B, Maeda, N, Greenspan, D S, Kellett, K & Hooper, N 2019, ' Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake ', Scientific Reports . https://doi.org/10.1038/s41598-019-47814-0
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
The development of cardiovascular disease is intimately linked to elevated levels of low-density lipoprotein (LDL) cholesterol in the blood. Hepatic LDL receptor (LDLR) levels regulate the amount of plasma LDL. We identified the secreted zinc metallo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae9398889d0b645d0a6175f4006391d
https://pubmed.ncbi.nlm.nih.gov/32042031
https://pubmed.ncbi.nlm.nih.gov/32042031