Zobrazeno 1 - 7
of 7
pro vyhledávání: '"B. K. J. LEONG"'
Publikováno v:
Journal of Applied Toxicology. 19:133-140
In collecting inhalation toxicity data for the evaluation of the health hazard from occupational exposure to the aerosols of a drug or a chemical, the determination of the inhaled dose in relation to the animal response is most desirable. Intratrache
Publikováno v:
Journal of Applied Toxicology. 18:149-160
The effectiveness of three techniques to deliver a diazo dye suspension into the lungs of rats was compared. The intratracheal nebulization (ITN) technique delivered 10 microl of the suspension per 5-ml puff of air in 10 puffs as an aerosol. The intr
Autor:
M. M. Cooper, T. W. Petry, P. Jeffrey, R. A. Jolly, D. A. Rop, T. J. Parker, C. P. Sabaitis, N. K. Burton, B. K. J. Leong
Publikováno v:
Journal of Applied Toxicology. 17:279-288
U-91502, a bisphosphonate for arthritic inflammation treatment, was evaluated for its parental toxicity. The objective was to differentiate between the parent drug and a reactive metabolite(s) as the proximate cause of the toxic effects using two met
Autor:
B. K. J. LEONG, J. E. LUND, J. A. GROEHN, J. K. COOMBS, C. P. SABAITIS, R. J. WEAVER, R. L. GRIFFIN
Publikováno v:
Toxicological Sciences. 9:645-658
Autor:
Royal J. Weaver, C. P. Sabaitis, J. A. Groehn, J. E. Lund, J. K. Coombs, B. K. J. Leong, R. L. Griffin
Publikováno v:
Fundamental and Applied Toxicology. 9:645-658
4,4′-Methylenedianiline (MDA) is an important chemical intermediate in the production of isocyanates and polyurethane elastomers and polymers. The health hazards from acute inhalation exposure to the aerosols were evaluated. Guinea pigs of albino a
Autor:
B. K. J. LEONG
Publikováno v:
Chemischer Informationsdienst. 6
Publikováno v:
Journal of toxicology and environmental health. 4(4)
Rats and hamsters were exposed to the dust of pulverized asbestos pipe covering at an average concentration of 85 mg/m(3) for 6 h/d, 5 d/wk, for 7 mo, followed by a lifetime observation period. In rats, the pulmonary responses were alveolar adenomato