Zobrazeno 1 - 10 of 1 236 pro vyhledávání: '"B. Judkins"'
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Akademický článek
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4
Addressing species specific metabolism and solubility issues in a quinoline series of oral PDE4 inhibitors
Autor: Lisa E. Ranshaw, Tracy Jane Shipley, Suzanne Elaine Keeling, Colin David Eldred, Nicola Mary Aston, B. Judkins, Ed Robinson, Kam Gohil, Naimisha Trivedi, Christopher James Lunniss, Andy Craven
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:137-140
Species specific conversion of the lead PDE4 inhibitor 1 to the quinolone 3 was identified as the major route of metabolism in the cynomolgus monkey. Modification of the template to give the cinnoline 9 retained potency and selectivity, and greatly i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb271e1e882da928f3b0ee05c4c9fb31
https://doi.org/10.1016/j.bmcl.2009.11.010
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5
[Untitled]
Autor: Joyce Nelson, Kerry Nixon, Stanley C. Gill, James A. Farmer, Mark B. Judkins, Philip M. Zack, Richard Bolin, Daniel W. Drolet, Chris Tucker, Julie Wolf, Raymond A. Bendele
Publikováno v: Pharmaceutical Research. 17:1503-1510
Purpose. The objective of this study was to determine the pharmacokinetics and safety for NX1838 following injection into the vitreous humor of rhesus monkeys.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a41feaea3a38054f6e07b27979a77bd6
https://doi.org/10.1023/a:1007657109012
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6
Detection and plasma pharmacokinetics of an anti-vascular endothelial growth factor oligonucleotide-aptamer (NX1838) in rhesus monkeys
Autor: Mark B. Judkins, Stanley C. Gill, Long-Shiuh Chen, Chris Tucker, Daniel W. Drolet, James A. Farmer
Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 732:203-212
Aptamers are oligonucleotide ligands selected, in vitro, to bind a specified target protein. The first aptamer to reach human clinical testing is NX1838, a polyethylene glycol conjugated aptamer that inhibits vascular endothelial growth factor. This
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dcd7c27c6305d85c906115d8f32a28f
https://doi.org/10.1016/s0378-4347(99)00285-6
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7
Long-period fiber gratings as band-rejection filters
Autor: Ashish Madhukar Vengsarkar, John E. Sipe, Paul Joseph Lemaire, J. B. Judkins, Vikram Bhatia, Turan Erdogan
Publikováno v: Journal of Lightwave Technology. 14:58-65
Optical fiber communication systems that use optical amplifiers are increasingly seeking high-performance devices that function as spectrally-selective band-rejection filters. For example, ASE filters that improve erbium amplifier performance and ban
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c5fd185407fd623ecadc4bb1158ef0
https://doi.org/10.1109/50.476137
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8
Effect of age at weaning (30 vs. 60 day) on intake, growth, serum hormone and metabolite profiles in young ewe and ram lambs
Autor: D. M. Hallford, L J Krysl, D W Holcombe, M. B. Judkins, S. W. Beam
Publikováno v: Canadian Journal of Animal Science. 75:209-218
Twenty-four Polypay lambs (12 sets of twins; 12 ewe and 12 ram lambs) born within a 3-d period were randomly allotted at birth within sex group to be weaned at either 30 (EW) or 60 (LW) d of age. Six lambs (three ewe and three ram lambs)/treatment we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca43d71293de011e97ca120f1058315b
https://doi.org/10.4141/cjas95-031
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9
Numerical analysis of a two-dimensional near-field probe
Autor: Richard W. Ziolkowski, Fred F. Froehlich, Justin B. Judkins, Joshua L. Kann, Tom D. Milster
Publikováno v: Ultramicroscopy. 57:251-256
A hybrid finite-difference-time-domain and angular spectrum technique is used to model near-field optical probe fields and the interaction of the fields with a pyrex substrate. Included in this analysis is a study of the effect of various nanometer s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::711c280bbfb2e3033513a8eb50f9e02c
https://doi.org/10.1016/0304-3991(94)00148-g
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10
Applications of the nonlinear finite difference time domain (NL-FDTD) method to pulse propagation in nonlinear media: Self-focusing and linear-nonlinear interfaces
Autor: Richard W. Ziolkowski, Justin B. Judkins
Publikováno v: Radio Science. 28:901-911
In an effort to meet an ever increasing demand for more accurate and realistic integrated photonics simulations, we have developed a multidimensional, nonlinear finite difference time domain (NL-FDTD) Maxwell's equations solver. The NL-FDTD approach
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffac27759c9dbea60b10f503b3008bde
https://doi.org/10.1029/93rs01100
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