Zobrazeno 1 - 10
of 140
pro vyhledávání: '"B. Janetzky"'
Amyloid-beta (Aβ) peptides are considered to be the cause of neuronal and synaptic cell death in Alzheimer’s disease (AD) since approximately 100 years. To date, it is assumed that Aβ-peptides arise from the proteolytic cleavage of the amyloid pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92a759e8c8d516bf2d2214fef078896
https://doi.org/10.1101/438630
https://doi.org/10.1101/438630
Publikováno v:
Journal of Cellular and Molecular Medicine
Simple, non-invasive tests for an early detection of degenerative dementia by use of biomarkers are urgently required. However, up to the present, no validated extracerebral diagnostic markers (plasma/serum, platelets, urine, connective tissue) for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f622ab97d8ad5540b0ede22c780a18
https://doi.org/10.1111/j.1582-4934.2008.00313.x
https://doi.org/10.1111/j.1582-4934.2008.00313.x
Autor:
Ludger Schöls, Christine Klein, Ullrich Wüllner, Karla Eggert, Wolfgang H. Oertel, Thomas Gasser, B. Janetzky, Gisela Antony
Publikováno v:
Movement Disorders. 22:611-618
Parkinson's disease (PD) is the second most common neurodegenerative disease. Although 10 gene loci have been identified to cause a Parkinsonian syndrome, these loci account only for a minority of PD patients. Large, systematic research programs are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b480f8d7df6979e0a10ad91813dfc9
https://doi.org/10.1002/mds.21331
https://doi.org/10.1002/mds.21331
Autor:
Gabriele Gille, B. Janetzky, T. Kolter, H. P. Hundemer, Wolf-Dieter Rausch, Heinz Reichmann, S.-T. Hung, Rudolf Moldzio
Publikováno v:
Journal of Neural Transmission. 109:633-643
Dopamine agonists are an important therapeutic strategy in the treatment of Parkinson's disease. They postpone the necessity for and reduce the required dose of L-3,4-dihydroxyphenylalanine (L-DOPA) medication thus protecting against the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6dba252119d932deda1b7bc954dd56
https://doi.org/10.1007/s007020200052
https://doi.org/10.1007/s007020200052
Autor:
Rudolf Moldzio, B. Janetzky, S.-T. Hung, Heinz Reichmann, Gabriele Gille, Wolf-Dieter Rausch, A. Engfer, A. Ngyuen
Publikováno v:
Journal of Neural Transmission. 109:157-169
Dopamine agonists play an important role in the treatment of Parkinson's disease by reducing the administration of L-3,4-dihydroxyphenylalanine (L-DOPA). The enzymatic and non-enzymatic conversion of L-DOPA is suspected to increase oxidative stress,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6377ba2712a5dd445470a0d93247527
https://doi.org/10.1007/s007020200011
https://doi.org/10.1007/s007020200011
Autor:
Jobst Böning, Manfred Gerlach, Mario E. Götz, Peter Riederer, Fritz Leblhuber, S. Pohli, T. Tatschner, H. Reichmann, B Janetzky, G. Ransmayr, Alexander Gottschalk, W. Gsell
Publikováno v:
Alcoholism: Clinical and Experimental Research. 25:717-725
Background: It is still difficult to define the biochemical mechanisms that cause alterations in neuronal function and plasticity and neuronal cell loss in the brains of alcohol-dependent patients. Methods: To evaluate the extent of cerebral alcohol-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d31f5ad6a578c10c2bc69c1508b91a
https://doi.org/10.1097/00000374-200105000-00013
https://doi.org/10.1097/00000374-200105000-00013
Autor:
Ralph Brückner, B. Janetzky, Karl Peters, Doris Feineis, Gerhard Bringmann, Ralf God, Jens Achim-Protzen, Eva-Maria Peters, Michael Blank, Heinz Reichmann
Publikováno v:
Scopus-Elsevier
Several N-alkanoyl derivatives (4-9 and 13-16) of the potent mitochondrial complex I inhibitor TaClo (1-trichlorom ethyl-1,2,3,4-tetrahydro-β-carboline, 2) have been synthesized in order to elucidate the role of hydrophobic portion in the inhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b4305fe9adb69d099821050b73376e
https://doi.org/10.1515/znc-2000-7-822
https://doi.org/10.1515/znc-2000-7-822
Autor:
Heinz Reichmann, B. Janetzky
Publikováno v:
Journal of Neurology. 247:II63-II68
The cause of Parkinson’s disease is still unknown. Nonetheless, there are some generally accepted hypotheses with respect to the cascade of dopaminergic cell degeneration. One of the factors is a decrease in respiratory chain complex I activity. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0a0731789ec382c14cfd15d1044749
https://doi.org/10.1007/pl00007763
https://doi.org/10.1007/pl00007763
Autor:
Gabriele Gille, Wolf-Dieter Rausch, Gerhard Bringmann, Heinz Reichmann, B. Janetzky, Thomas Pabst
Publikováno v:
Drug Development Research. 50:153-156
Mastigophorenes are dimeric isocuparane-type sesquiterpenes of plant origin which have been found to exhibit neurotrophic properties. In this study, a simplified synthetically produced analog (1) and its dimethylether (2) were screened for potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebaa8c0168831905526335101adce6f5
https://doi.org/10.1002/1098-2299(200006)50:2<153::aid-ddr4>3.0.co
https://doi.org/10.1002/1098-2299(200006)50:2<153::aid-ddr4>3.0.co
Autor:
Wolf-Dieter Rausch, Gabriele Gille, Heinz Reichmann, M. Abdel-mohsen, Gerhard Bringmann, B. Janetzky, Ralf God
Publikováno v:
Drug Development Research. 46:51-56
Pyridoindoles (carbolines) are relatively common indole alkaloids in most diets and in our ecosystem. Besides 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its active metabolite, MPP + , several psychotropic β-carbolines have been describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d353889cb0bf7af84505d8c32e40ef46
https://doi.org/10.1002/(sici)1098-2299(199901)46:1<51::aid-ddr8>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199901)46:1<51::aid-ddr8>3.0.co