Výsledky vyhledávání - "B. J. Stevenson"

Defects in Protein Glycosylation Cause SHO1-Dependent Activation of a STE12 Signaling Pathway in Yeast

Autor: George F. Sprague, Yoshifumi Jigami, Janet Schultz, Joe Horecka, B. J. Stevenson, Paul J. Cullen

Publikováno v: Genetics. 155:1005-1018

In haploid Saccharomyces cerevisiae, mating occurs by activation of the pheromone response pathway. A genetic selection for mutants that activate this pathway uncovered a class of mutants defective in cell wall integrity. Partial loss-of-function all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4885183e2e40df200e83d1e236f333ad
https://doi.org/10.1093/genetics/155.3.1005

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Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms

Autor: Stevan Marcus, Aaron M. Neiman, B. J. Stevenson, Hao-Peng Xu, I. Herskowitz, G. F. Sprague, Michael Wigler

Publikováno v: Scopus-Elsevier

We present genetic evidence that three presumptive protein kinases of Schizosaccharomyces pombe, byr2, byr1, and spk1 that are structurally related to protein kinases of Saccharomyces cerevisiae, STE11, STE7, and FUS3, respectively, are also function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b673d878578ee9781e40b64ae5eb1ad
https://doi.org/10.1091/mbc.4.1.107

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Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein

Autor: George F. Sprague, Beverly Errede, B. J. Stevenson, Nelson Rhodes

Publikováno v: Genes & Development. 6:1293-1304

STE4 encodes the beta-subunit of a heterotrimeric guanine nucleotide-binding protein (G protein) that is an early and essential component of the pheromone signal transduction pathway. From a ste4 deletion strain we have isolated both dominant and rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a57379a2280659cb344bba2959e230
https://doi.org/10.1101/gad.6.7.1293

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Enhancing the efficiency of introducing precise mutations into the mouse genome by hit and run gene targeting

Autor: P, Dickinson, W L, Kimber, F M, Kilanowski, S, Webb, B J, Stevenson, D J, Porteous, J R, Dorin

Publikováno v: Transgenic research. 9(1)

The creation of precise clinical mutations by targeting is important in elucidating disease pathogenesis using mouse models. 'Hit and run' gene targeting is an elegant method to achieve this goal. This uses first a positive selection to introduce the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::896d6db112308a60a2ce136504c9b44b
https://pubmed.ncbi.nlm.nih.gov/10853269

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Laboratory and clinical studies in support of cystic fibrosis gene therapy using pCMV-CFTR-DOTAP

Autor: G, McLachlan, L P, Ho, H, Davidson-Smith, J, Samways, H, Davidson, B J, Stevenson, A D, Carothers, E W, Alton, P G, Middleton, S N, Smith, G, Kallmeyer, U, Michaelis, S, Seeber, K, Naujoks, A P, Greening, J A, Innes, J R, Dorin, D J, Porteous

Publikováno v: Gene therapy. 3(12)

The first phase I study of cystic fibrosis gene therapy using cationic liposomes to deliver the cystic fibrosis conductance regulator gene to the nose reported partial and transient correction of the nasal transepithelial ion transport defect, While

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc0c00308a5882775271389e17e8b4e0
https://pubmed.ncbi.nlm.nih.gov/8986438

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Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae

Autor: Betsy Ferguson, B. J. Stevenson, John R. Pringle, George F. Sprague, C. De Virgilio, Gustav Ammerer, Erfei Bi

We have selected yeast mutants that exhibit a constitutively active pheromone-response pathway in the absence of the beta subunit of the trimeric G protein. Genetic analysis of one such mutant revealed that it contained recessive mutations in two dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd90a6b590184ed2c11d2eec11f196a5

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The yeast pheromone response pathway: new insights into signal transmission

Autor: B, Ferguson, J, Horecka, J, Printen, J, Schultz, B J, Stevenson, G F, Sprague

Publikováno v: Cellularmolecular biology research. 40(3)

The yeast (Saccharomyces cerevisiae) pheromone response pathway is one of the best understood eukaryotic signal transduction pathways. Nonetheless, it is likely that components and regulators of the pathway remain to be identified. We have employed t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::034209d4e0fd6f2edcebd8edfe436653
https://pubmed.ncbi.nlm.nih.gov/7874199

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Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice

Autor: E. W. F. W. Alton, P. G. Middleton, N. J. Caplen, S. N. Smith, D. M. Steel, F. M. Munkonge, P. K. Jeffery, D. M. Geddes, S. L. Hart, R. Williamson, K. I. Fasold, A. D. Miller, P. Dickinson, B. J. Stevenson, G. McLachlan, J. R. Dorin, D. J. Porteous

Publikováno v: Nature genetics. 5(2)

We report gene transfer to the Edinburgh insertional mutant mouse (cf/cf), delivering CFTR cDNA-liposome complexes into the airways by nebulization. We show full restoration of cAMP related chloride responses in some animals and demonstrate, in the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f8764e040310608fde86f761df1599
https://pubmed.ncbi.nlm.nih.gov/7504552

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Correction: Corrigendum: Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice

Autor: Peter K. Jeffery, David J. Porteous, K. I. Fasold, Natasha J. Caplen, P. Dickinson, G. McLachlan, Robert Williamson, Eric W.F.W. Alton, Peter G. Middleton, Felix M. Munkonge, Duncan M. Geddes, Julia R. Dorin, D. M. Steel, Andrew D. Miller, Stephen L. Hart, B. J. Stevenson, Stephen N. Smith

Publikováno v: Nature Genetics. 5:312-312

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94cdf6445694568d3e575669e21205ad
https://doi.org/10.1038/ng1193-312a

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Identification of a Cell-Specific DNA-Binding Activity That Interacts with a Transcriptional Activator of Genes Expressed in the Acinar Pancreas

Autor: M Cockell, Michel Strubin, O Hagenbüchle, B J Stevenson, P K Wellauer

Publikováno v: Molecular and Cellular Biology. 9:2464-2476

Footprint analysis of the 5'-flanking regions of the alpha-amylase 2, elastase 2, and trypsina genes, which are expressed in the acinar pancreas, showed multiple sites of protein-DNA interaction for each gene. Competition experiments demonstrated tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe751277f1d5c25f2124c30b5de6a39
https://doi.org/10.1128/mcb.9.6.2464-2476.1989

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