Výsledky vyhledávání - "B. J. Roessler"

Methods for adenovirus-mediated gene transfer to synovium in vivo

Autor: B J, Roessler

Publikováno v: Methods in molecular medicine. 7

The synovial membrane that lines diarthrodial joints is composed of a loose layer of cells (1-4 cells in depth) that overlie the surface of articular and periarticular subsynovial tissues including connective tissue, adipose tissue, tendon, bone, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7467c6089ad619bf10af147a69af405
https://pubmed.ncbi.nlm.nih.gov/24493441

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Overexpression of human intestinal oligopeptide transporter in mammalian cells via adenoviral transduction

Autor: C P, Hsu, J M, Hilfinger, E, Walter, H P, Merkle, B J, Roessler, G L, Amidon

Publikováno v: Pharmaceutical research. 15(9)

Our goals are to establish an in vitro screening system and to evaluate a new approach in improving oral absorption of peptides and peptide-like drugs by overexpression of the human intestinal oligopeptide transporter (hPepT1). This study characteriz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c93c54d0866c4781cb2a2800d1966a8
https://pubmed.ncbi.nlm.nih.gov/9755888

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Beta cyclodextrins enhance adenoviral-mediated gene delivery to the intestine

Autor: M A, Croyle, B J, Roessler, C P, Hsu, R, Sun, G L, Amidon

Publikováno v: Pharmaceutical research. 15(9)

In general, the intestinal epithelium is quite refractory to viral and non-viral methods of gene transfer. In this report, various cyclodextrin formulations were tested for their ability to enhance adenoviral transduction efficiency in two models of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5296488c7e88820294f7629743d75b49
https://pubmed.ncbi.nlm.nih.gov/9755884

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The absence of accessible vitronectin receptors in differentiated tissue hinders adenoviral-mediated gene transfer to the intestinal epithelium in vitro

Autor: E, Walter, M A, Croyle, B J, Roessler, G L, Amidon

Publikováno v: Pharmaceutical research. 14(9)

Adenoviral (Ad) vectors have been used as efficient tools for gene therapy in various tissues, whereas in some differentiated epithelium transduction efficiency is almost abolished.Caco-2 cell monolayers were chosen as an in vitro model for the diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::16c9103c32f662beb39765d027d2d2f9
https://pubmed.ncbi.nlm.nih.gov/9327451

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Expression of human interleukin-1 receptor antagonist in mouse lungs using a recombinant adenovirus: effects on vector-induced inflammation

Autor: R D, McCoy, B L, Davidson, B J, Roessler, G B, Huffnagle, R H, Simon

Publikováno v: Gene therapy. 2(7)

Pulmonary inflammation is a major obstacle to using adenovirus-based vectors for gene transfer to the lung. Since the pro-inflammatory cytokine, interleukin-1 (IL-1), is expressed early following adenovirus infection, we hypothesized that inhibition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ec97ff8e2d308b52e1369d5ae70d7b1
https://pubmed.ncbi.nlm.nih.gov/7584121

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A recombinant adenoviral vector expressing a soluble form of VCAM-1 inhibits VCAM-1/VLA-4 adhesion in transduced synoviocytes

Autor: S J, Chen, J M, Wilson, D K, Vallance, J W, Hartman, B L, Davidson, B J, Roessler

Publikováno v: Gene therapy. 2(7)

Intra-articular injection of recombinant adenovirus has been shown to be a feasible approach to the introduction of genetic reagents into synovial tissues in vivo. Rheumatoid arthritis (RA) is an autoimmune disorder characterized by the infiltration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1727a39581f0c165259d72ed8d8ec250
https://pubmed.ncbi.nlm.nih.gov/7584125

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Point Mutations in PRPS1, the Gene Encoding the PRPP Synthetase (PRS) 1 Isoform, Underlie X-Linked PRS Superactivity Associated with Purine Nucleotide Inhibitor-Resistance

Autor: B. J. Roessler, Patrick R. Smith, R. L. Switzer, J. M. Nosal, Michael Becker, T. D. Palella

Publikováno v: Purine and Pyrimidine Metabolism in Man VIII ISBN: 9781461361053

The aim of these studies was to establish the genetic basis of PRPP synthetase (PRS) superactivity, an X chromosome-linked disorder of purine metabolism characterized by gout, uric acid overproduction1, and, in some families, neurologic and/or develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81060123b7ecf9b7f152634882afc7c4
https://doi.org/10.1007/978-1-4615-2584-4_147

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Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells

Autor: D S, Shewach, L K, Zerbe, T L, Hughes, B J, Roessler, X O, Breakefield, B L, Davidson

Publikováno v: Cancer gene therapy. 1(2)

The antiviral agents ganciclovir, 1-beta-D-arabinofuranosylthymine (araT), acyclovir, and 5-iodo-5'-amino-2',5'-dideoxyuridine were cytotoxic to rat C6 glioma cells expressing retrovirally transferred herpes simplex virus (HSV) type 1 thymidine kinas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd12d42e8f19547fea4b944de6b21a75
https://pubmed.ncbi.nlm.nih.gov/7621241

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In vivo transfer of a reporter gene to the retina mediated by an adenoviral vector

Autor: T, Li, M, Adamian, D J, Roof, E L, Berson, T P, Dryja, B J, Roessler, B L, Davidson

Publikováno v: Investigative ophthalmologyvisual science. 35(5)

The ability of replication-deficient adenovirus to mediate gene transfer to retinal cells was evaluated.A replication-deficient adenoviral vector, AdCMV beta A.ntlacZ, which contains the bacterial beta-galactosidase (lacZ) reporter gene, was injected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2994172e21491b1913e945505e129dc
https://pubmed.ncbi.nlm.nih.gov/8163343

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