Zobrazeno 1 - 10
of 483
pro vyhledávání: '"B. Issekutz"'
Autor:
Anikó E. Malik, Drew Slauenwhite, Sarah M. McAlpine, John G. Hanly, Jean S. Marshall, Beáta Dérfalvi, Thomas B. Issekutz
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundThe role of type I and type III interferons (IFNs) in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) is still poorly understood. The objective of this study was to examine the hypothesis that IFN expression profiles in th
Externí odkaz:
https://doaj.org/article/6604fe21c02a4a40848cb6c541f0e5ce
Autor:
Anikó E. Malik, Drew Slauenwhite, Sarah M. McAlpine, John G. Hanly, Jean S. Marshall, Thomas B. Issekutz
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectiveAntigen-presenting dendritic cells (DCs) and monocytes play an essential role in rheumatoid arthritis (RA) pathogenesis, however, their tolerogenic potential remains unclear. Herein, the tolerogenic profiles of DCs are characterized in treat
Externí odkaz:
https://doaj.org/article/ada887f28e424002807018d3e254353f
Autor:
Nora Alrumayyan, Drew Slauenwhite, Sarah M. McAlpine, Sarah Roberts, Thomas B. Issekutz, Adam M. Huber, Zaiping Liu, Beata Derfalvi
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 18, Iss 1, Pp 1-11 (2022)
Abstract Background Prolidase deficiency (PD) is an autosomal recessive inborn multisystemic disease caused by mutations in the PEPD gene encoding the enzyme prolidase D, leading to defects in turnover of proline-containing proteins, such as collagen
Externí odkaz:
https://doaj.org/article/03ad05a01adb459c9c83d1949a6d70a8
Autor:
Sarah M. McAlpine, Sarah E. Roberts, John J. Heath, Fabian Käsermann, Andrew C. Issekutz, Thomas B. Issekutz, Beata Derfalvi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Intravenous immunoglobulin (IVIG) is an effective immunomodulatory treatment for immune dysregulation diseases. However, the mechanisms by which it reduces systemic inflammation are not well understood. NK cell cytotoxicity is decreased by IVIG in wo
Externí odkaz:
https://doaj.org/article/ea9f95a0079b4145a5cc45eefede390a
Publikováno v:
Clinical and Investigative Medicine. 44:E5-18
Purpose: This literature review summarizes the main immunological characteristics of type III interferons (IFN) and highlights the clinically relevant aspects and future therapeutic perspectives for these inflammatory molecules. Source: Relevant arti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae160536451c4635f2f2f3a978ce674c
https://doi.org/10.25011/cim.v44i2.36622
https://doi.org/10.25011/cim.v44i2.36622
Autor:
Sarah M. McAlpine, Sarah E. Roberts, Breanna K.V. Hargreaves, Claire Bullock, Suzanne Ramsey, Elizabeth Stringer, Bianca Lang, Adam Huber, Bence György, Fruzsina Erdélyi, Thomas B. Issekutz, Beáta Dérfalvi
Publikováno v:
The Journal of rheumatology.
ObjectiveTo evaluate microRNA expression in synovial fluid (SF), plasma, and leukocytes from patients with juvenile idiopathic arthritis (JIA).MethodsMicroRNA expression in pooled JIA plasma and SF was assessed by absolute quantitative droplet digita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd51f48fab43870361566412d22c367
https://pubmed.ncbi.nlm.nih.gov/35840148
https://pubmed.ncbi.nlm.nih.gov/35840148
Publikováno v:
Immunology and Cell Biology
Natural killer (NK) cells are innate effector cells with critical roles not only in tumor immunosurveillance and viral immunity, but also in bacterial and fungal infections. Toll‐like receptor 2 (TLR2) can be important in the early and sustained im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc2bd256a0708308e0253a8cbe31ace
https://doi.org/10.1111/imcb.12379
https://doi.org/10.1111/imcb.12379
Autor:
Brenda Reid, Alison Haynes, Parwinder Gill, Julia Upton, Vy Hong-Diep Kim, Christine McCusker, Thomas B. Issekutz, Luis Murguia-Favela, Tamar S. Rubin, Kyla J. Hildebrand, Rae Brager, Chaim M. Roifman
Publikováno v:
LymphoSign Journal. 7:109-115
Adenosine deaminase (ADA) deficiency is a form of severe combined immunodeficiency. Aberrant mutations in the ADA gene result in loss of ADA activity and the toxic accumulation of metabolites that damage both immune and non-immune organs. While patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af7d9bd8560c91b9f49c9f80b0aa2824
https://doi.org/10.14785/lymphosign-2020-0008
https://doi.org/10.14785/lymphosign-2020-0008
Autor:
Drew Slauenwhite, J G Hanly, Thomas B. Issekutz, Jean S. Marshall, Aniko Malik, Sarah M. McAlpine, Ian D. Haidl
Publikováno v:
Arthritis & Rheumatology. 72:1091-1102
OBJECTIVE Rheumatoid arthritis (RA) is a chronic inflammatory disease mediated through complex immunologic pathways. Among RA patients receiving low-dose methotrexate (MTX) monotherapy, approximately one-half exhibit a meaningful clinical response wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca535e4fa32095fa142290612b48f467
https://doi.org/10.1002/art.41223
https://doi.org/10.1002/art.41223
Autor:
Nora Alrumayyan, Drew Slauenwhite, Sarah M. McAlpine, Sarah Roberts, Thomas B. Issekutz, Adam M. Huber, Zaiping Liu, Beata Derfalvi
Publikováno v:
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology. 18(1)
Background Prolidase deficiency (PD) is an autosomal recessive inborn multisystemic disease caused by mutations in the PEPD gene encoding the enzyme prolidase D, leading to defects in turnover of proline-containing proteins, such as collagen. PD is c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b11a35dfa423f08486197b9b9275c2
https://pubmed.ncbi.nlm.nih.gov/35197125
https://pubmed.ncbi.nlm.nih.gov/35197125