Zobrazeno 1 - 10
of 12
pro vyhledávání: '"B. I. Loehr"'
Autor:
Dale L. Godson, Susantha Gomis, B.C. Karvonen, Robert Rankin, Philip Willson, Lorne A. Babiuk, S. van Drunen Littel-van den Hurk, Reno Pontarollo, B. I. Loehr, Rolf Hecker
Publikováno v:
Vaccine. 20:3014-3022
The adjuvanticity of a synthetic oligodeoxynucleotide containing unmethylated CpG motifs (CpG ODN) was determined in cattle. Calves were immunized with a truncated secreted version of glycoprotein D (tgD) of bovine herpes virus-1 (BHV-1) formulated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c564d45d702ba1d8e780c10b36c183
https://doi.org/10.1016/s0264-410x(02)00216-5
https://doi.org/10.1016/s0264-410x(02)00216-5
Autor:
B. I. Loehr, Reno Pontarollo, Robert Rankin, Laura J.P. Latimer, S. van Drunen Littel-van den Hurk, Lorne A. Babiuk, P. Willson
Publikováno v:
Journal of General Virology. 82:3035-3043
DNA vaccines have several advantages over conventional vaccines. One of the most important characteristics is the presentation of antigen via both MHC class I and class II receptors. Although this generally results in strong T-cell responses, antibod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c664d2296dc07bcd247720cb6589cfd
https://doi.org/10.1099/0022-1317-82-12-3035
https://doi.org/10.1099/0022-1317-82-12-3035
Autor:
P. Willson, Lorne A. Babiuk, S. van Drunen Littel-van den Hurk, Robert Rankin, Reno Pontarollo, T. King, B. I. Loehr
Publikováno v:
Virology. 289:327-333
Mucosal surfaces are the primary sites for the transmission of infectious agents including viruses, so effective vaccines generally should induce mucosal immunity. Furthermore, noninvasive delivery is desirable because of the ease of application, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188103ce44a3fbce0615625e2b1f74c4
https://doi.org/10.1006/viro.2001.1143
https://doi.org/10.1006/viro.2001.1143
Autor:
Lorne A. Babiuk, Reno Pontarollo, Robert Rankin, Sylvia van Drunen Littel-van den Hurk, B. I. Loehr, Richard R. E. Uwiera, Volker Gerdts
Publikováno v:
Advanced Drug Delivery Reviews. 43:13-28
DNA-based vaccination constitutes one of the most recent approaches to vaccine development. This technology is in principle one of the most simple and yet versatile methods of inducing both humoral and cellular immune responses, as well as protection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8565f7aa5330bfb5ec046a57549fe28
https://doi.org/10.1016/s0169-409x(00)00074-0
https://doi.org/10.1016/s0169-409x(00)00074-0
Publikováno v:
Veterinary Immunology and Immunopathology. 76:1-23
Polynucleotide immunization has captured the imagination of numerous researchers and commercial companies around the world as a novel approach for inducing immunity in animals. Clearly, the ‘proof-of-principle’ has been demonstrated both in roden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35a2665e419b6af2285aadc58f9033f
https://doi.org/10.1016/s0165-2427(00)00198-7
https://doi.org/10.1016/s0165-2427(00)00198-7
Publikováno v:
Journal of Virology. 74:6077-6086
Vaccination by a mucosal route is an excellent approach to the control of mucosally acquired infections. Several reports on rodents suggest that DNA vaccines can be used to achieve mucosal immunity when applied to mucosal tissues. However, with the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea60d0182548fc5bc1c677c7a414c606
https://doi.org/10.1128/jvi.74.13.6077-6086.2000
https://doi.org/10.1128/jvi.74.13.6077-6086.2000
Publikováno v:
Virology. 265:46-56
Particle-mediated delivery was used as a method to vaccinate ruminants with a DNA vaccine. The optimal conditions for gene gun-based delivery of gold particles into the epidermal layer of the skin were determined. After delivery of the gold particles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e6a38a2236d0d42d41ee7e33d5b071
https://doi.org/10.1006/viro.1999.0032
https://doi.org/10.1006/viro.1999.0032
Publikováno v:
Archives of Virology. 143:667-679
Mucosal disease (MD) can be induced in cattle persistently infected with noncytopathogenic bovine viral diarrhea virus (ncp BVD virus) by superinfecting them with antigenically related cytopathogenic (cp) BVD virus strains. While some of these animal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab07596287f995ba56a6c3f70d8efec4
https://doi.org/10.1007/s007050050322
https://doi.org/10.1007/s007050050322
Autor:
Reno A. Pontarollo, B. I. Loehr, Shawn Babiuk, Lorne A. Babiuk, S. van Drunen Littel-van den Hurk
Publikováno v:
Vaccine. 21(7-8)
It is generally recognized that DNA vaccines are often less effective in large animals than in mice. One possible reason for this reduced effectiveness may be transfection deficiency and the low level of expression elicited by plasmid vectors in larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f38285fb125f9f77f41e978e1e0ea5
https://pubmed.ncbi.nlm.nih.gov/12531334
https://pubmed.ncbi.nlm.nih.gov/12531334
Publikováno v:
Developments in biologicals. 104
DNA immunization of livestock has proven to be more challenging than similar approaches in mice. To identify parameters, which could influence the magnitude and type of immune response generated by DNA immunization, we have assessed promoter strength
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59e03f59c7bcb8a647256826c18f4df7
https://pubmed.ncbi.nlm.nih.gov/11713827
https://pubmed.ncbi.nlm.nih.gov/11713827