Zobrazeno 1 - 10
of 174
pro vyhledávání: '"B. I. Buzykin"'
Autor:
V. N. Nabiullin, B. I. Buzykin, D. A. Tatarinov, L. R. Kashapov, R. S. Garaev, R. V. Chestnova, A. V. Il\\'yasov, V. V. Zobova, Vladimir F. Mironov
Publikováno v:
Russian Chemical Bulletin. 63:2114-2125
We studied some pharmacological properties of dimephosphone P—C and aza analogs, viz., dimethyl (2-methyl-4-oxopent-2-yl)phosphonate, which is one of the first organophosphorus drugs having no anticholinesterase activity. Replacement of two P—O
Publikováno v:
Russian Journal of General Chemistry. 84:1157-1178
5-Methyl-2-phenyl-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3-c]pyridin-3-one exists as zwitterion with a proton localized on the nitrogen atom of the piperidine ring and negative charge delocalized over the pyrazololate fragment. The compound is stable i
Autor:
A. A. Kostin, A. V. Il'yasov, Vladimir I. Morozov, D. A. Tatarinov, B. I. Buzykin, Ekaterina V. Mironova, V. N. Nabiullin, Dmitry B. Krivolapov, Vladimir F. Mironov
Publikováno v:
Russian Journal of General Chemistry. 84:901-910
Dialkyl(diaryl)-(2-methyl-4-oxopent-2-yl)phosphine oxide oximes have been synthesized for the first time. According to the X-ray diffraction data, these compounds in crystal exist as a single E isomer. Their structure in solution and the E/Z isomer r
Publikováno v:
Russian Journal of General Chemistry. 84:531-544
5-Methyl-2-phenyl-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3-c]pyridin-3-one has been synthesized and shown to exist in crystal as zwitterionic structure with the proton localized on the nitrogen atom in the piperidine ring and negative charge delocalize
Publikováno v:
Russian Journal of General Chemistry. 83:2084-2087
The interaction of 1-alkyl-3-alkoxycarbonylpyperidin-4-ones with phenylhydrazine has led to 5-alkyl-2-phenyl-3,3a,4,5,6,7-hexahydro-2H-pyrazolo-[4,3-c]pyridin-3-ones. The prepared compounds are unstable and undergo a series of uncommon transformation
Autor:
B. I. Buzykin
Publikováno v:
Review Journal of Chemistry. 3:207-238
An analysis was carried out of the electron and spatial structure of 1,3-dipolar reagents. Their reactivity was shown to be strongly dependent on the nature of atoms of dipolar triad, the nature of substituents, and production conditions. For example
Publikováno v:
Journal of Structural Chemistry. 54:630-634
Molecular and crystal structures of dimephosphone nicotinoylhydrazone and dimephosphone isonicotinoylhydrazone exhibiting antiphthisic activity are studied. In contrast to aroylhydrazones of arylaldehydes, existing in the crystalline state as a mixtu
Autor:
A. A. Kostin, Vladimir F. Mironov, B. I. Buzykin, T. A. Baronova, D. A. Tatarinov, Dmitry B. Krivolapov, Ekaterina V. Mironova, A. B. Dobrynin
Publikováno v:
Russian Journal of Organic Chemistry. 49:516-525
A new approach has been developed to the synthesis of dialkyl(diaryl)(2-methyl-4-oxopent-2-yl)-phosphine oxides that are structural analogs of the drug dimephosphon. This approach is based on the reaction of 2-chloro-3,3,5-trimethyl-3H-1,2λ5-oxaphos
Autor:
R. S. Garaev, L. R. Kashapov, B. I. Buzykin, R. V. Chestnova, Vladimir F. Mironov, R. Sh. Valeev, V. N. Nabiullin
Publikováno v:
Pharmaceutical Chemistry Journal. 47:35-39
Nicotinoyl- and isonicotinoylhydrazones of 2-dimethoxyphosphoryl-2-methylpentan-4-one (the active ingredient of the medicinal preparation Dimephosphone) were synthesized. It was shown that crystals of both hydrazones contained a single spatial form o
Autor:
A. A. Kostin, Ekaterina V. Mironova, V. N. Nabiullin, I. A. Litvinov, Vladimir F. Mironov, D. A. Tatarinov, B. I. Buzykin
Publikováno v:
Russian Journal of General Chemistry. 82:1629-1645
Dimephosphone (2-dimethoxyphosphoryl-2-methylpentan-4-one) phenyl-, nitrophenyl-, benzoyl-, and 4-nitrobenzoylhydrazones were synthesized. The compounds in crystals were shown to have a steric form exclusively of the E-isomer. The structure of hydraz